RAGE antagonist peptide

Product Name: RAGE antagonist peptide
CAS No.: 1092460-91-7
Chemical Name: RAGE antagonist peptide
Synonyms: RAGE antagonist;RAGE antagonist peptide;RAGE antagonist peptide TFA;L-Leucinamide, N-acetyl-L-α-glutamyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-methionyl-L-α-glutamyl-L-lysyl-L-α-glutamyl-;(4S,7S,10S,13S,16S,19S,22S,25S,28S)-28-Acetamido-4-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)carbamoyl)-7,22-bis(4-aminobutyl)-10-(2-carboxyethyl)-16,25-diisobutyl-19-isopropyl-13-(2-(methylthio)ethyl)-6,9,12,15,18,21,24,27-octaoxo-5,8,11,14,17,20,23,26-octaazahentriacontanedioic acid
CBNumber: CB24796602
Molecular Formula: C57H101N13O17S
Formula Weight: 1272.57
MOL File: 1092460-91-7.mol

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RAGE antagonist peptide Property

Boiling point:: 1608.4±65.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 4.43±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in water
Sequence: Ac-Glu-Leu-Lys-Val-Leu-Met-Glu-Lys-Glu-Leu-NH2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6259
Product name: RAGEantagonistpeptide
Packaging: 1
Price: $96
Updated: 2021/12/16

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RAGE antagonist peptide Chemical Properties,Usage,Production

Uses

RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities[1][2].

in vivo

RAGE antagonist peptide (RAP, 100 μg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo^[1].
RAGE antagonist peptide (RAP) reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth^[1].
In mice bearing asthma, RAGE antagonist peptide (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide also reduces total, cytoplasmic and nuclear levels of β-catenin, enhanced β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function^[2].

Animal Model:	Cancer cells expressing the NFκB-luc reporter implanted into immune-deficient mice^[1].
Dosage:	100 μg.
Administration:	Intratumoral delivery (or intraperitoneally).
Result:	Systemic administration caused a substantial reduction (p<0.05) in the NFκB signal 5 h after injection.

storage

Store at -20°C

References

[1] Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18(16):4356-64. DOI:10.1158/1078-0432.CCR-12-0221
[2] Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173(17):2600-13. DOI:10.1111/bph.13539

RAGE antagonist peptide Preparation Products And Raw materials

Raw materials

Preparation Products

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RAGE antagonist peptide Suppliers

China 37 United Kingdom 1 United States 3 USA 1 Global 42

Bide Pharmatech Ltd.

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1092460-91-7, RAGE antagonist peptideRelated Search:

H-LEU-LEU-HIS-ASP-LYS-GLY-LYS-SER-ILE-GLN-ASP-LEU-ARG-ARG-ARG-PHE-PHE-LEU-HIS-HIS-LEU-ILE-ALA-GLU-ILE-HIS-THR-ALA-NH2 11-Dideuterolinoleic acid Met-RANTES (human) IKKγ NBD Inhibitory Peptide GALANIN-(2-13)-GLU-HIS-(PRO)3-(ALA-LEU)2-ALA-AMIDE ALPHA-CGRP (8-37) (RAT)

RAGE antagonist peptide

L-Leucinamide, N-acetyl-L-α-glutamyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-methionyl-L-α-glutamyl-L-lysyl-L-α-glutamyl-

RAGE antagonist

RAGE antagonist peptide TFA

(4S,7S,10S,13S,16S,19S,22S,25S,28S)-28-Acetamido-4-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)carbamoyl)-7,22-bis(4-aminobutyl)-10-(2-carboxyethyl)-16,25-diisobutyl-19-isopropyl-13-(2-(methylthio)ethyl)-6,9,12,15,18,21,24,27-octaoxo-5,8,11,14,17,20,23,26-octaazahentriacontanedioic acid

1092460-91-7

C57H101N13O17S