RAGE antagonist peptide
- Product Name
- RAGE antagonist peptide
- CAS No.
- 1092460-91-7
- Chemical Name
- RAGE antagonist peptide
- Synonyms
- RAGE antagonist;RAGE antagonist peptide;RAGE antagonist peptide TFA;L-Leucinamide, N-acetyl-L-α-glutamyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-methionyl-L-α-glutamyl-L-lysyl-L-α-glutamyl-;(4S,7S,10S,13S,16S,19S,22S,25S,28S)-28-Acetamido-4-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)carbamoyl)-7,22-bis(4-aminobutyl)-10-(2-carboxyethyl)-16,25-diisobutyl-19-isopropyl-13-(2-(methylthio)ethyl)-6,9,12,15,18,21,24,27-octaoxo-5,8,11,14,17,20,23,26-octaazahentriacontanedioic acid
- CBNumber
- CB24796602
- Molecular Formula
- C57H101N13O17S
- Formula Weight
- 1272.57
- MOL File
- 1092460-91-7.mol
RAGE antagonist peptide Property
- Boiling point:
- 1608.4±65.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 4.43±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- Ac-Glu-Leu-Lys-Val-Leu-Met-Glu-Lys-Glu-Leu-NH2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 6259
- Product name
- RAGEantagonistpeptide
- Packaging
- 1
- Price
- $96
- Updated
- 2021/12/16
RAGE antagonist peptide Chemical Properties,Usage,Production
Uses
RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities[1][2].
in vivo
RAGE antagonist peptide (RAP, 100 μg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo[1].
RAGE antagonist peptide (RAP) reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth[1].
In mice bearing asthma, RAGE antagonist peptide (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide also reduces total, cytoplasmic and nuclear levels of β-catenin, enhanced β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function[2].
| Animal Model: | Cancer cells expressing the NFκB-luc reporter implanted into immune-deficient mice[1]. |
| Dosage: | 100 μg. |
| Administration: | Intratumoral delivery (or intraperitoneally). |
| Result: | Systemic administration caused a substantial reduction (p<0.05) in the NFκB signal 5 h after injection. |
storage
Store at -20°C
References
[1] Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18(16):4356-64. DOI:10.1158/1078-0432.CCR-12-0221
[2] Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173(17):2600-13. DOI:10.1111/bph.13539
RAGE antagonist peptide Preparation Products And Raw materials
Raw materials
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