11-Dideuterolinoleic acid
- Product Name
- 11-Dideuterolinoleic acid
- CAS No.
- 1051366-32-5
- Chemical Name
- 11-Dideuterolinoleic acid
- Synonyms
- POL-6326);Balixafortide TFA salt;Balixafortide (POL6326;11-Dideuterolinoleic acid;POL6326 (Balixafortide) TFA salt;Balixafortide(POL6326) (free base);Cyclo[L-alanyl-L-cysteinyl-L-seryl-L-alanyl-D-prolyl-(2S)-2,4-diaminobutanoyl-L-arginyl-L-tyrosyl-L-cysteinyl-L-tyrosyl-L-glutaminyl-L-lysyl-D-prolyl-L-prolyl-L-tyrosyl-L-histidyl], cyclic (2→9)-disulfide
- CBNumber
- CB73159854
- Molecular Formula
- C84H118N24O21S2
- Formula Weight
- 1864.11
- MOL File
- 1051366-32-5.mol
11-Dideuterolinoleic acid Property
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);45.33(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);45.33(Max Conc. mM) - pka
- 9.89±0.15(Predicted)
- Water Solubility
- Water: 100 mg/mL (53.64 mM);
- Sequence
- H-Ala-Cys-Ser-Ala-Pro-Arg-Tyr-Cys-Tyr-Gln-Lys-Pro-Pro-Tyr-His-OH（Disulfide bridges Cys-Cys）
N-Bromosuccinimide Price
- Product number
- DC21522
- Product name
- Balixafortide(POL6326)
- Purity
- >95%
- Packaging
- 10mg
- Price
- $500
- Updated
- 2021/12/16
11-Dideuterolinoleic acid Chemical Properties,Usage,Production
Uses
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects[1][2].
in vivo
Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability[1].
IC 50
CXCR4: <10 nM (IC50)
References
[1] Zimmermann J, et al. Anti-tumor cell activity and in vitro profile of the next generation CXCR4 antagonist Balixafortide. Ann Oncol. 2018 Oct;29 Suppl 8:viii103.
[2] Karpova D, et al. Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers-results of a dose escalation trial. J Transl Med. 2017 Jan 3;15(1):2. DOI:10.1186/s12967-016-1107-2
11-Dideuterolinoleic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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