ChemicalBook > CAS DataBase List > ALPHA-CGRP (8-37) (RAT)
ALPHA-CGRP (8-37) (RAT)
- Product Name
- ALPHA-CGRP (8-37) (RAT)
- CAS No.
- 129121-73-9
- Chemical Name
- ALPHA-CGRP (8-37) (RAT)
- Synonyms
- CGRP 8-37 (RAT);Rat CGRP-(8-37);PubChem ID: 90479762;RAT CGRP-(8-37)?, >98%;ALPHA-CGRP (8-37) (RAT);a-CGRP (8-37) (Mouse, rat);α-CGRP (8-37) (mouse, rat);Rat CGRP-(8-37) (TFA salt);Alpha-CGRP (8-37) (mouse, rat);VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
- CBNumber
- CB1142835
- Molecular Formula
- C138H224N42O41
- Formula Weight
- 3127.51
- MOL File
- 129121-73-9.mol
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ALPHA-CGRP (8-37) (RAT) Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- solubility
- H2O : 50 mg/mL (15.99 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-OH
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Tocris
- Product number
- 1169
- Product name
- CGRP8-37(rat)
- Packaging
- 500U
- Price
- $342
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC109404
- Product name
- Alpha-CGRP (8-37) (mouse, rat) trifluoroacetate salt
- Packaging
- 250ug
- Price
- $130
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC109404
- Product name
- Alpha-CGRP (8-37) (mouse, rat) trifluoroacetate salt
- Packaging
- 500ug
- Price
- $225
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-7927
- Product name
- RatCGRP-(8-37)
- Purity
- 98.54%
- Packaging
- 500ug
- Price
- $228
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-7927
- Product name
- RatCGRP-(8-37)
- Purity
- 98.54%
- Packaging
- 1mg
- Price
- $348
- Updated
- 2021/12/16
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ALPHA-CGRP (8-37) (RAT) Chemical Properties,Usage,Production
Uses
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
in vivo
CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2].
storage
Store at -20°C
References
[1] Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. DOI:10.1016/s0304-3959(00)00242-6
[2] Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30. DOI:10.1016/0006-8993(94)90393-x
ALPHA-CGRP (8-37) (RAT) Preparation Products And Raw materials
Raw materials
Preparation Products
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ALPHA-CGRP (8-37) (RAT) Suppliers
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- 821-50328103-801 18930552037
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View Lastest Price from ALPHA-CGRP (8-37) (RAT) manufacturers
Career Henan Chemical Co
- Product
- ALPHA-CGRP (8-37) (RAT) 129121-73-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13
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