1,4-Dichlorophthalazine
- Product Name
- 1,4-Dichlorophthalazine
- CAS No.
- 4752-10-7
- Chemical Name
- 1,4-Dichlorophthalazine
- Synonyms
- 1,4-Dichlorophtalazine;1,4-Dichloro-2,3-benzodiazine;Dichlorophthalazine;1,4-Dichloropyrazine;1,4-DICHLOROPHALAZINE;1,4-DICHLOROPHTHALAZINE;Phthalazine, 1,4-dichloro-;1,4-Dichlorophthalazine>1,4-Dichlorophthalazine,98%;JR-8370, 1,4-Dichlorophthalazine, 97%
- CBNumber
- CB2483520
- Molecular Formula
- C8H4Cl2N2
- Formula Weight
- 199.04
- MOL File
- 4752-10-7.mol
1,4-Dichlorophthalazine Property
- Melting point:
- 160-162 °C (lit.)
- Boiling point:
- 397.3±22.0 °C(Predicted)
- Density
- 1.486±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform, Methanol
- pka
- -0.44±0.30(Predicted)
- form
- Powder or Crystalline Powder
- color
- White to yellow
- Water Solubility
- Sparingly soluble in water.(0.26 g/L) (25°C),
- Sensitive
- Moisture Sensitive
- InChI
- InChI=1S/C8H4Cl2N2/c9-7-5-3-1-2-4-6(5)8(10)12-11-7/h1-4H
- InChIKey
- ODCNAEMHGMYADO-UHFFFAOYSA-N
- SMILES
- C1(Cl)C2=C(C=CC=C2)C(Cl)=NN=1
- CAS DataBase Reference
- 4752-10-7(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 126020
- Product name
- 1,4-Dichlorophthalazine
- Purity
- 95%
- Packaging
- 5g
- Price
- $159.16
- Updated
- 2025/07/31
- Product number
- 126020
- Product name
- 1,4-Dichlorophthalazine
- Purity
- 95%
- Packaging
- 1g
- Price
- $44.6
- Updated
- 2023/06/20
- Product number
- D3749
- Product name
- 1,4-Dichlorophthalazine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- D3749
- Product name
- 1,4-Dichlorophthalazine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- D436165
- Product name
- 1,4-Dichlorophthalazine
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
1,4-Dichlorophthalazine Chemical Properties,Usage,Production
Uses
1,4-Dichlorophthalazine was used as starting reagent in the synthesis of series of 4-aryl-1-(4-methylpiperazin-1-yl)phthalazines. It was used as coupling reagent in the synthesis of novel soluble polymer-bound ligand. It was often used as building block in medicinal chemistry synthesis.
Uses
1,4-Dichlorophthalazine Oftens used building block in medicinal chemistry synthesis.1,2
Synthesis Reference(s)
Canadian Journal of Chemistry, 43, p. 2708, 1965 DOI: 10.1139/v65-379
Synthesis
1445-69-8
4752-10-7
General procedure for the synthesis of 1,4-dichlorophthalazine from phthaloyl hydrazine: phthaloyl hydrazine (1.68 g, 10 mmol) was added to a stirred solution of phosphoryl chloride (15 ml). The mixture was heated to 110°C and kept for 1 hour. After completion of the reaction (monitored by TLC), the reaction mixture was cooled to room temperature. The mixture was slowly added dropwise to crushed ice and stirred for 10 minutes. Subsequently, the mixture was filtered through a Brinell funnel. The filter cake was washed to neutrality with distilled water and dried in vacuum. 1,4-Dichlorophthalazine (1.85 g, 90.1% yield) was finally obtained as a white solid.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 4, p. 1236 - 1238
[2] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 235 - 244
[3] Chemical Biology and Drug Design, 2013, vol. 81, # 5, p. 591 - 599
[4] New Journal of Chemistry, 2016, vol. 40, # 7, p. 6070 - 6076
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 6, p. 1576 - 1579
1,4-Dichlorophthalazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-Dichlorophthalazine manufacturers
- Product
- 1,4-Dichlorophthalazine 4752-10-7
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-15
- Product
- 1,4-Dichlorophthalazine 4752-10-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 200kgs/month
- Release date
- 2021-11-04
- Product
- 1,4-Dichlorophthalazine 4752-10-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-21