BMS-1166
- Product Name
- BMS-1166
- CAS No.
- 1818314-88-3
- Chemical Name
- BMS-1166
- Synonyms
- BMS-1166;PD-1/PD-L1-IN1;BMS-1166 (PD-1/PD-L1-IN1);PD-1/PD-L1-IN1 BMS-1166;BMS-1166 (Synonyms: PD-1/PD-L1-IN1);BMS 1166Q: What is BMS 1166 Q: What is the CAS Number of BMS 1166;Inhibitor,BMS1166,BMS 1166,activation,immune,cell,interaction,BMS-1166,dimerization,checkpoint,inhibit;D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)-;(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid
- CBNumber
- CB24843928
- Molecular Formula
- C36H33ClN2O7
- Formula Weight
- 641.11
- MOL File
- 1818314-88-3.mol
BMS-1166 Property
- Boiling point:
- 817.5±65.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- form
- A crystalline solid
- pka
- 2.03±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 5mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 25mg
- Price
- $1750
- Updated
- 2021/12/16
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 50mg
- Price
- $2750
- Updated
- 2021/12/16
- Product number
- CS-0022454
- Product name
- BMS-1166
- Purity
- 99.86%
- Packaging
- 100mg
- Price
- $3950
- Updated
- 2021/12/16
BMS-1166 Chemical Properties,Usage,Production
Biological Activity
BMS-1166 is a novel and potent inhibitor of PD-1/PD-L1 interaction with IC50 of 1.4 nM.
in vitro
BMS-1166 had low toxicity to the tested cell lines and prevented the interaction of soluble PD-L1 with PD-1 receptors expressed on the cell surface. It attenuates the inhibitory effect of PD-L1 on T cell receptor-mediated T lymphocyte activation.
target
| Target | Value |
| PD-1/PD-L1 interaction () | 1.4 nM |
BMS-1166 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-1166 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32165
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38632
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81