(R)-ZINC-3573 ((R)-ZINC3573)

Product Name: (R)-ZINC-3573 ((R)-ZINC3573)
CAS No.: 2089389-15-9
Chemical Name: (R)-ZINC-3573 ((R)-ZINC3573)
Synonyms: ZINC3573;ZINC-3573;ZINC 3573;(R)-ZINC-3573, 10 mM in DMSO;(R)-ZINC-3573 ((R)-ZINC3573);(R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine;(3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine;(3R)-N,N-dimethyl-1-{5-phenylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-amine;3-Pyrrolidinamine, N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-, (3R)-
CBNumber: CB24844415
Molecular Formula: C18H21N5
Formula Weight: 307.39
MOL File: 2089389-15-9.mol

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(R)-ZINC-3573 ((R)-ZINC3573) Property

Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 8.69±0.20(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1699
Product name: (R)-ZINC-3573
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $117
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1699
Product name: (R)-ZINC-3573
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $477
Updated: 2025/07/31

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(R)-ZINC-3573 ((R)-ZINC3573) Chemical Properties,Usage,Production

Uses

(R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch[1].

Biological Activity

(R)-ZINC-3573 is a selective agonist probe of the orphan receptor Mas-related G-protein coupled receptor member X2 (MRGPRX2), a G-protein coupled receptor (GPCR) selectively expressed in mast cells and dorsal root and trigeminal ganglia primary sensory neurons of primates. Lack of selective and potent probes has made it difficult to determine MRGPRX2 funtion. (R)-ZINC-3573 was shown to be a potent and selective agonist with an EC50 value of 760 nM for MRGPRX2 and little activity for MRGPRX1 or over 350 other GPCRs and 97 kinases tested. (R)-ZINC-3573 activates endogenous MRGPRX2 expressed in a human mast cell line and induced degranulation and calcium release. (S)-ZINC-3573 is inactive and can be used as a control.

storage

Store at +4°C

References

[1] Lansu K, et al. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol. 2017 May;13(5):529-536. DOI:10.1038/nchembio.2334

(R)-ZINC-3573 ((R)-ZINC3573) Preparation Products And Raw materials

Raw materials

Preparation Products

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2089389-15-9, (R)-ZINC-3573 ((R)-ZINC3573)Related Search:

4-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-hydroxy-5-[4-(pentyloxy)phenyl]-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one ZINC03129319 1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- 1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine 3,4-dihydro-1H-isoquinolin-2-yl-[3-(1H-indol-4-yl)-1,2,4-oxadiazol-5-yl]methanone 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- ZINC13466751 2-(2-oxobenzo[cd]indol-1(2H)-yl)-N-[2-(trifluoromethyl)phenyl]acetamide 6-(3,4-dimethoxyphenyl)-3-(2-thienyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 6-(3,4-dimethoxyphenyl)-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

(3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine

(R)-ZINC-3573 ((R)-ZINC3573)

ZINC 3573

ZINC3573

ZINC-3573

3-Pyrrolidinamine, N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-, (3R)-

(R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine

(3R)-N,N-dimethyl-1-{5-phenylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-amine

(R)-ZINC-3573, 10 mM in DMSO

2089389-15-9