ChemicalBook > CAS DataBase List > 1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-
1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-
- Product Name
- 1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-
- CAS No.
- 1211825-25-0
- Chemical Name
- 1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-
- Synonyms
- ZN27;ZN-27;ZN 27;ZINC40099027;FAK activator 1;2-(4-methoxyphenyl)-N-[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]pyrrolidine-1-carboxamide;1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-
- CBNumber
- CB39269858
- Molecular Formula
- C23H26F3N3O3
- Formula Weight
- 449.47
- MOL File
- 1211825-25-0.mol
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1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- Property
- Boiling point:
- 613.0±55.0 °C(Predicted)
- Density
- 1.308±0.06 g/cm3(Predicted)
- solubility
- DMSO: Sparingly soluble: 1-10 mg/ml
- form
- Solid
- pka
- 12.12±0.70(Predicted)
- color
- White to off-white
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1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- Chemical Properties,Usage,Production
Uses
ZINC40099027 is a FAK activator. ZINC40099027 promotes FAK phosphorylation, inducing mucosal healing in murine models. ZINC40099027 can be used for Gastroduodenal ulcer disease research[1].
References
[1] Wang Q, et al. Discovery of Novel Small-Molecule FAK Activators Promoting Mucosal Healing. ACS Med Chem Lett. 2021 Feb 16;12(3):356-364. DOI:10.1021/acsmedchemlett.0c00311
[2] QINGGANG WANG. Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing[J]. Scientific Reports, 2019. DOI: 10.1038/s41598-019-51183-z
1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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