(R)-ZINC-3573 ((R)-ZINC3573)

Product Name: (R)-ZINC-3573 ((R)-ZINC3573)
CAS No.: 2089389-15-9
Chemical Name: (R)-ZINC-3573 ((R)-ZINC3573)
Synonyms: ZINC3573;ZINC-3573;ZINC 3573;(R)-ZINC-3573, 10 mM in DMSO;(R)-ZINC-3573 ((R)-ZINC3573);(R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine;(3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine;(3R)-N,N-dimethyl-1-{5-phenylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-amine;3-Pyrrolidinamine, N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-, (3R)-
CBNumber: CB24844415
Molecular Formula: C18H21N5
Formula Weight: 307.39
MOL File: 2089389-15-9.mol

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(R)-ZINC-3573 ((R)-ZINC3573) Property

Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 8.69±0.20(Predicted)
form: Solid
color: Off-white to light yellow
InChI: 1S/C18H21N5/c1-21(2)15-9-11-22(13-15)18-12-16(14-6-4-3-5-7-14)20-17-8-10-19-23(17)18/h3-8,10,12,15H,9,11,13H2,1-2H3/t15-/m1/s1
InChIKey: XKBSPAZCFAIBJL-OAHLLOKOSA-N
SMILES: CN([C@H](CC1)CN1C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Skin Irrit. 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1699
Product name: (R)-ZINC-3573
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $125
Updated: 2026/04/30

Sigma-Aldrich

Product number: SML1699
Product name: (R)-ZINC-3573
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $511
Updated: 2026/04/30

Cayman Chemical

Product number: 41312
Product name: (R)-ZINC3573
Purity: ≥95%
Packaging: 5mg
Price: $86
Updated: 2026/04/30

Cayman Chemical

Product number: 41312
Product name: (R)-ZINC3573
Purity: ≥95%
Packaging: 10mg
Price: $138
Updated: 2026/04/30

Cayman Chemical

Product number: 41312
Product name: (R)-ZINC3573
Purity: ≥95%
Packaging: 25mg
Price: $301
Updated: 2026/04/30

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(R)-ZINC-3573 ((R)-ZINC3573) Chemical Properties,Usage,Production

Uses

(R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch[1].

Biological Activity

(R)-ZINC-3573 is a selective agonist probe of the orphan receptor Mas-related G-protein coupled receptor member X2 (MRGPRX2), a G-protein coupled receptor (GPCR) selectively expressed in mast cells and dorsal root and trigeminal ganglia primary sensory neurons of primates. Lack of selective and potent probes has made it difficult to determine MRGPRX2 funtion. (R)-ZINC-3573 was shown to be a potent and selective agonist with an EC50 value of 760 nM for MRGPRX2 and little activity for MRGPRX1 or over 350 other GPCRs and 97 kinases tested. (R)-ZINC-3573 activates endogenous MRGPRX2 expressed in a human mast cell line and induced degranulation and calcium release. (S)-ZINC-3573 is inactive and can be used as a control.

storage

Store at +4°C

References

[1] Lansu K, et al. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol. 2017 May;13(5):529-536. DOI:10.1038/nchembio.2334

(R)-ZINC-3573 ((R)-ZINC3573) Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-ZINC-3573 ((R)-ZINC3573) Suppliers

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2089389-15-9, (R)-ZINC-3573 ((R)-ZINC3573)Related Search:

4-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-hydroxy-5-[4-(pentyloxy)phenyl]-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one ZINC03129319 1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- 1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine 3,4-dihydro-1H-isoquinolin-2-yl-[3-(1H-indol-4-yl)-1,2,4-oxadiazol-5-yl]methanone 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- ZINC13466751 2-(2-oxobenzo[cd]indol-1(2H)-yl)-N-[2-(trifluoromethyl)phenyl]acetamide 6-(3,4-dimethoxyphenyl)-3-(2-thienyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 6-(3,4-dimethoxyphenyl)-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

(3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine

(R)-ZINC-3573 ((R)-ZINC3573)

ZINC 3573

ZINC3573

ZINC-3573

3-Pyrrolidinamine, N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-, (3R)-

(R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine

(3R)-N,N-dimethyl-1-{5-phenylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-amine

(R)-ZINC-3573, 10 mM in DMSO

2089389-15-9