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STAUROSPORINE

Product Name
STAUROSPORINE
CAS No.
62996-74-1
Chemical Name
STAUROSPORINE
Synonyms
STSP;AM-2282;Staurosporin;Stauroporine;CBR113;CS-2206;Sporosin;CGP 39360;CCRIS 3272;Astrosporin
CBNumber
CB2486697
Molecular Formula
C28H26N4O3
Formula Weight
466.54
MOL File
62996-74-1.mol
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STAUROSPORINE Property

Melting point:
270°C
alpha 
D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
Boiling point:
677.5±55.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
RTECS 
KD5084000
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
White to pale yellow solid
pka
14.25±0.70(Predicted)
color 
Off white to pale yellow
Water Solubility 
Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
BRN 
1060573
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey
HKSZLNNOFSGOKW-WIFUGMKFSA-N
CAS DataBase Reference
62996-74-1
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
40-45-36/37/38-46
Safety Statements 
36/37-53-36-26-45
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
2
F 
8-10
HazardClass 
3
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S5921
Product name
Staurosporine from Streptomyces sp.
Purity
for molecular biology, ≥95% (HPLC)
Packaging
0.1mg
Price
$307
Updated
2024/03/01
Sigma-Aldrich
Product number
S5921
Product name
Staurosporine from Streptomyces sp.
Purity
for molecular biology, ≥95% (HPLC)
Packaging
0.5mg
Price
$883
Updated
2024/03/01
Sigma-Aldrich
Product number
S4400
Product name
Staurosporine from Streptomyces sp.
Purity
≥98% (HPLC), film
Packaging
0.1mg
Price
$223.2
Updated
2024/03/01
Sigma-Aldrich
Product number
S4400
Product name
Staurosporine from Streptomyces sp.
Purity
≥98% (HPLC), film
Packaging
0.5mg
Price
$802
Updated
2024/03/01
Sigma-Aldrich
Product number
569397
Product name
Staurosporine, Streptomyces sp.
Purity
Staurosporine,CAS62996-74-,isacell-permeable,potent,reversible,ATP-compe
Packaging
100μg
Price
$159
Updated
2024/03/01
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STAUROSPORINE Chemical Properties,Usage,Production

Description

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively. However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.

Chemical Properties

Light Yellow Solid

Occurrence

A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.

Uses

Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.

Uses

Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.

Definition

ChEBI: Staurosporine is an indolocarbazole alkaloid and an organic heterooctacyclic compound. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a geroprotector, a bacterial metabolite and an apoptosis inducer. It is a conjugate base of a staurosporinium.

General Description

A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.

Biological Activity

Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Reversible: yes

storage

+4°C

References

1) Omura et al. (1977) A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization; J. Antibiot., 30 275 2) Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases; Trends in Pharmacological Science 10 218

STAUROSPORINE Preparation Products And Raw materials

Raw materials

Preparation Products

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STAUROSPORINE Suppliers

Australia 2 Belgium 2 Canada 3 China 261 Czech Republic 1 France 2 Germany 10 India 6 Japan 2 Poland 1 South Africa 1 Spain 2 Switzerland 3 The Netherlands 1 United Kingdom 15 United States 47 Global 359
Shanghai Hanjing Chemicals Co., Ltd.
Tel
021-54285032 13641685631
Fax
+86 (21) 5443 7651
Email
gerry.shu@hanjingchemicals.com
Country
China
ProdList
76
Advantage
55
Wuxi enqiao Pharmaceutical Technology Co., Ltd
Tel
0510-83591909 18018392058
Fax
0510-83591909
Email
info@enbridgepharm.com
Country
China
ProdList
180
Advantage
58
Fujian Kerui Pharmaceutical Co., Ltd.
Tel
+86-591-83309157; 18505919179
Fax
0591-83309157
Email
23115188@qq.com
Country
China
ProdList
18
Advantage
62
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1994
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
4257
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
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View Lastest Price from STAUROSPORINE manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Staurosporine 62996-74-1
Price
US $5.00/kg
Min. Order
1kg
Purity
99.92%
Supply Ability
50000tons
Release date
2024-04-23
Henan Fengda Chemical Co., Ltd
Product
STAUROSPORINE 62996-74-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-03
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
STAUROSPORINE 62996-74-1
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-05-07

62996-74-1, STAUROSPORINERelated Search:

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  • 62996-74-1
  • C28H26N4O3
  • BioChemical
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