Sulfamide Property

Melting point:

90-92 °C(lit.)

Density 

1.611 g/mL at 25 °C(lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

water: soluble50mg/mL, clear, colorless to faintly yellow

form 

Crystalline Powder, Free From Visible Impurities

pka

10.87±0.60(Predicted)

color 

White to practically white , free from visible impurities

PH

5.67 at 21.7℃ and 10g/L

Water Solubility 

soluble

Sensitive 

Moisture Sensitive

Merck 

14,8922

InChIKey

NVBFHJWHLNUMCV-UHFFFAOYSA-N

CAS DataBase Reference

7803-58-9(CAS DataBase Reference)

NIST Chemistry Reference

Sulfamide(7803-58-9)

EPA Substance Registry System

Sulfamide (7803-58-9)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

F 

9

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

28530090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Sulfamide Chemical Properties,Usage,Production

Description

Sulfamide is a white solid substance that is normally produced by reacting sulfuryl chloride with ammonia. Sulfamide is stable under normal conditions and soluble in acetone and DMSO. Sulfamide may also refer to the functional group in organic chemistry, and it consists of at least one group attached to a nitrogen atom of sulfamide.
It is a carbonic anhydrase inhibitor and is widely used as a pharmaceutical intermediate.
Sulfamide is sensitive to moisture, thus should be kept away from water and humidity. It should also be stored away from oxidizing agents. Sulfamide should be kept in a tightly closed container and placed in a cool, dry, and well-ventilated condition.

Chemical Properties

White Solid

Uses

Sulfamide and its derivatives can also be used to prepare fused thiadiazine systems, Reaction with 2-aminoacetophenones affords IH-2,1,3-benzothia- diazine 2,2-dioxides 77 (65JOC3960). The corresponding 3,4-dihydro deriv- atives are readily available from 2-aminobenzylamines with either sulfuryl chloride (70M1443) or sulfamide (66USP3278532; 71MI055). These kinds of compounds can also be obtained from N-aryl-N'-alkylsulfamides and s-trioxane in a reaction involving cyclization by intramolecular sulfamido- methylation (79JOC2032) (Scheme 30).

Uses

Similar to urea in many of its reactions, but is more acidic, and can act as a dibasic acid.

Uses

A carbonic anhydrase inhibitor; used for treatment of cancer.

Definition

ChEBI: The simplest of the sulfamic acids consisting of a single sulfur atom covalently bound by single bonds to two amino groups and by double bonds to two oxygen atoms.

Purification Methods

Crystallise sulfamide from absolute EtOH. It decomposes at 250o. [Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I pp 482-483 1963.]