METHYL 1-BOC-4-PIPERIDINEACETATE

Product Name: METHYL 1-BOC-4-PIPERIDINEACETATE
CAS No.: 175213-46-4
Chemical Name: METHYL 1-BOC-4-PIPERIDINEACETATE
Synonyms: METHYL 1-BOC-4-PIPERIDINEACETATE;Methyl N-Boc-4-piperidineacetate;Methyl-1-Bocpiperidine-4-acetate;Methyl N-BOC-piperidine-4-acetate;Methyl 1-N-Boc-4-piperidineacetate;1-Boc-4-Piperidine acetate methyl ester;N-BOC-4-PIPERIDINEACETIC ACID METHYL ESTER;1-Boc-4-Piperidine acetic acid methyl ester;Methyl 1-Boc-4-piperidine acetate - [M12265];Methyl (piperidin-4-yl)acetate, N-BOC protected
CBNumber: CB2491392
Molecular Formula: C13H23NO4
Formula Weight: 257.33
MOL File: 175213-46-4.mol

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METHYL 1-BOC-4-PIPERIDINEACETATE Property

Boiling point:: 323.1±15.0 °C(Predicted)
Density: 1.062±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -1.88±0.40(Predicted)
Appearance: Colorless to light yellow Liquid
CAS DataBase Reference: 175213-46-4

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Safety

HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M295748
Product name: Methyl1-Boc-4-piperidineacetate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140306
Product name: tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
Packaging: 1g
Price: $60
Updated: 2021/12/16

Synthonix

Product number: M12265
Product name: Methyl1-Boc-4-piperidineacetate
Purity: 95+%
Packaging: 1g
Price: $30
Updated: 2021/12/16

Synthonix

Product number: M12265
Product name: Methyl1-Boc-4-piperidineacetate
Purity: 95+%
Packaging: 5g
Price: $40
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140306
Product name: tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
Packaging: 2g
Price: $104
Updated: 2021/12/16

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METHYL 1-BOC-4-PIPERIDINEACETATE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Methyl 1-Boc-4-piperidineacetate is used as a pharmaceutical intermediate. It can be used in the preparation of intranasal pharmaceutical compositions of CGRP inhibitors for the treatment of migraine.

Synthesis

169206-65-9

175213-46-4

General procedure for the synthesis of methyl N-Boc-4-piperidineacetate from tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate: 1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylidene]piperidine (875 mg) was dissolved in ethanol (10 mL), to which 10% of palladium-carbon catalyst (~50% water content, 730 mg) was added. The reaction mixture was subjected to catalytic hydrogenation at room temperature and at atmospheric pressure for 3 days. Upon completion of the reaction, the catalyst was removed by filtration and the solvent was subsequently removed by distillation under reduced pressure to afford the target product methyl N-Boc-4-piperidineacetate (871 mg, 99% yield). The product was characterized by 1H-NMR (CDCl3): δ 1.16 (2H, m), 1.45 (9H, s), 1.65 (2H, m), 1.93 (1H, m), 2.25 (2H, d, J = 6.8 Hz), 2.72 (2H, br), 3.68 (3H, s), 4.08 (2H, br). Mass spectrometry (FAB) analysis showed m/z: 258 (M + H)+.

References

[1] Patent: EP1104754, 2001, A1
[2] Patent: EP1577302, 2005, A1. Location in patent: Page/Page column 121-122
[3] Patent: US2006/94707, 2006, A1. Location in patent: Page/Page column 43
[4] Patent: US2007/259850, 2007, A1. Location in patent: Page/Page column 79
[5] Patent: WO2011/123232, 2011, A1. Location in patent: Page/Page column 9

METHYL 1-BOC-4-PIPERIDINEACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 1-BOC-4-PIPERIDINEACETATE Suppliers

China 124 Europe 1 Germany 2 India 2 United Kingdom 5 United States 12 Global 146

SiChuang NanBu Honesty Technology Co., Ltd.

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View Lastest Price from METHYL 1-BOC-4-PIPERIDINEACETATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-butyl 4-(2-methoxy-2-oxo-ethyl)piperidine-1-carboxylate 175213-46-4
Price: US $2.20-8.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons
Release date: 2025-07-08

Career Henan Chemical Co

Product: METHYL 1-BOC-4-PIPERIDINEACETATE 175213-46-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-13

175213-46-4, METHYL 1-BOC-4-PIPERIDINEACETATERelated Search:

1-Boc-4-(2-hydroxyethyl)piperidine METHYL 1-BOC-4-PIPERIDINEACETATE 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER 4-(BROMO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE 1-BOC-4-(ETHOXYCARBONYL-HYDROXY-METHYL)-PIPERIDINE 4-(AMINO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-Butyl 4-(2-methoxy-2-oxoacetyl)-3-oxopiperidine-1-carboxylate 4-(ETHOXYCARBONYL-IODO-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER METHYL 2-ALLYL-N-BOC-4-PIPERIDINYL ACETATE (S)-BENZYLOXYCARBONYL-N'-T-BUTYLOXYCARBONYL-4-PIPERIDYLGLYCINE METHYL ESTER (S)-4-(AMINO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-BENZYLOXYCARBONYL-N'-T-BUTYLOXYCARBONYL-4-PIPERIDYLGLYCINE METHYL ESTER 2-BROMO-2- (1-TERT-BUTOXYCARBONYL-PIPERIDIN-4-YL)-MALONIC ACID DIMETHYL ESTER (R)-4-(AMINO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-(1-TERT-BUTOXYCARBONYL-PIPERIDIN-4-YL)-MALONIC ACID DIMETHYL ESTER Methyl 2-benzyl-8-Boc-2,8-diaza-spiro[4.5]decane-4-carboxylate TERT-BUTYL 4-((ETHOXYCARBONYL)METHYL)PIPERIDINE-1-CARBOXYLATE

Methyl (piperidin-4-yl)acetate, N-BOC protected

N-BOC-4-PIPERIDINEACETIC ACID METHYL ESTER

METHYL 1-BOC-4-PIPERIDINEACETATE

t-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

Methyl N-Boc-4-piperidineacetate Methyl 1-Boc-4-piperidineacetate 4-((Methoxycarbonyl)methyl)piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

1-Boc-4-Piperidine acetate methyl ester

1-Boc-4-Piperidine acetic acid methyl ester

tert-butyl 4-((methoxycarbonyl)methyl)piperidine-1-carboxylate

Methyl N-BOC-piperidine-4-acetate

2-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}propanoate

ert-butyl 4-(2-Methoxy-2-oxoethyl)piperidine-1-carboxylate

benzyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

Methyl 1-N-Boc-4-piperidineacetate

4-Piperidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

Methyl N-Boc-4-piperidineacetate

Methyl 1-[(1,1-dimethylethoxy)carbonyl]-4-piperidineacetate

Methyl 1-Boc-4-piperidine acetate - [M12265]

Methyl-1-Bocpiperidine-4-acetate

175213-46-4

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