2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER

Uses

Product Name: 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER
CAS No.: 59184-90-6
Chemical Name: 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER
Synonyms: ETHYL 4-PIPERIDINEACETATE;ETHYL 4-PIPERIDINYLACETATE;Ethyl 2-piperidin-4-ylacetate;methyl 2-(4-piperidyl)acetate;ETHYL 2-(4-PIPERIDINYL)ACETATE;4-piperidine Acetate Ethyl Ester;2-piperidine Acetate Ethyl Ester;methyl 2-piperidin-4-ylethanoate;PIPERIDINE-4-YL-ACETIC ETHYL ESTER;4-PIPERADINEACETIC ACID ETHYL ESTER
CBNumber: CB9281138
Molecular Formula: C9H17NO2
Formula Weight: 171.24
MOL File: 59184-90-6.mol

More

Less

2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Property

Melting point:: 192 °C (decomp)
Boiling point:: 67°C/0.22mm
Density: 0.969±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form: liquid
pka: 10.41±0.10(Predicted)
CAS DataBase Reference: 59184-90-6(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TRC

Product number: E926658
Product name: Ethyl2-(Piperidin-4-yl)acetate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 127088
Product name: Ethyl2-(4-piperidinyl)acetate
Purity: >95%
Packaging: 1g
Price: $81
Updated: 2021/12/16

Matrix Scientific

Product number: 127088
Product name: Ethyl2-(4-piperidinyl)acetate
Purity: >95%
Packaging: 500mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-W7
Product name: Ethyl (piperidin-4-yl)acetate
Packaging: 1g
Price: $24
Updated: 2021/12/16

AK Scientific

Product number: W7206
Product name: 2-(Piperidin-4-yl)-aceticacidethylester
Packaging: 5g
Price: $134
Updated: 2021/12/16

More

Less

2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

Piperidine derivatives have significant research value in the pharmaceutical field as drug intermediates. 4-Piperidine acetate methyl ester is also an important piperidine derivative drug intermediate, mainly used in the synthesis of drugs for various neurological diseases, such as convulsions, anti-epileptic drugs, and sedatives.

Synthesis

40110-55-2

59184-90-6

General procedure for the synthesis of ethyl 4-piperidineacetate from ethyl 2-(1-benzylpiperidin-4-ylidene)acetate: palladium/carbon catalyst (3.94 g) was added to a solution of 2-(1-benzylpiperidin-4-ylidene)ethyl acetate (24 g, 93 mmol) in ethyl acetate (300 mL). The reaction mixture was placed in an H-cubic hydrogenation reactor and the reaction conditions were set at 55 °C and 55 psi for 16 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford ethyl 4-piperidineacetate as a colorless oil (15 g, 90% yield). The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts δ: 4.10 (m, 2H), 3.03 (d, J = 16.4 Hz, 2H), 2.59 (t, J = 16.4 Hz, 2H), 2.19 (d, J = 9.6 Hz, 2H), 1.87 (m, 1H), 1.67 (d, J = 17.2 Hz, 2H ), 1.23 (t, J = 9.6Hz, 3H), 1.10 (m, 2H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 11, p. 3065 - 3067
[2] Patent: WO2013/107336, 2013, A1. Location in patent: Page/Page column 17; 18
[3] Patent: US2015/80380, 2015, A1. Location in patent: Paragraph 0081; 0137; 0138; 0139
[4] Synthetic Communications, 2003, vol. 33, # 13, p. 2329 - 2338

2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Suppliers

China 101 France 1 Germany 3 India 4 Japan 1 United Kingdom 4 United States 19 Global 133

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Shangchem Co., Ltd.

Tel: +86-21-68182121
Fax: +86-21-68182121
Country: China
ProdList: 882
Advantage: 52

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

skychemical Co.Ltd

Tel: 021-20958197 20965099
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 1183
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

More

Less

View Lastest Price from 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER manufacturers

Shanghai CRM New Material Technology Co., LTD

Product: Ethyl 2-(piperidin-4-yl)acetate 59184-90-6
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10t
Release date: 2022-09-22

Career Henan Chemical Co

Product: 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER 59184-90-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

59184-90-6, 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTERRelated Search:

ETHYL 4-PIPERIDONE-3-CARBOXYLATE HYDROCHLORIDE 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER METHYL N-CBZ-3-PIPERIDINEACETATE METHYL 1-BOC-4-PIPERIDINEACETATE 3-METHOXYCARBONYLMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER PIPERIDIN-3-YL-ACETIC ACID ETHYL ESTER,2-(PIPERIDIN-3-YL)-ACETIC ACID ETHYL ESTER (R)-1-Boc-3-piperidineacetic acid methyl ester (R)-1-Cbz-3-Piperidineacetic Acid Methyl Ester Methylphenidate hydrochloride (S)-1-Boc-3-piperidineacetic acid methyl ester (S)-3-Piperidineacetic acid methyl ester hydrochloride PIPERIDIN-2-YL-ACETIC ACID ETHYL ESTER (S)-1-Cbz-3-Piperidineacetic Acid Methyl Ester PIPERIDIN-3-YL-ACETIC ACID ETHYL ESTER,2-(PIPERIDIN-3-YL)-ACETIC ACID ETHYL ESTER (R)-(3-TERT-BUTOXYCARBONYLAMINO-PIPERIDIN-2-YL)-ACETIC ACID ETHYL ESTER ETHYL 3-QUINUCLIDINECARBOXYLATE N-BENZOYLMEROQUINENE TERT-BUTYL ESTER ETHYL 4-PIPERIDINEACETATE HCL

PIPERIDIN-4-YL-ACETIC ACID ETHYL ESTER

PIPERIDINE-4-YL-ACETIC ETHYL ESTER

(Piperidin-4-yl)acetic acid ethyl ester, 4-(2-Ethoxy-2-oxoethyl)piperidine

Ethyl 2-(4-piperidinyl)acetate hydrochloride

4-PIPERIDINE ACETIC ACID ETHYL ESTER

2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER

ETHYL 4-PIPERIDINEACETATE

ETHYL 2-(4-PIPERIDINYL)ACETATE

Ethyl 2-piperidin-4-ylacetate

2-piperidine Acetate Ethyl Ester

4-piperidine Acetate Ethyl Ester

ETHYL 4-PIPERIDINYLACETATE

4-PIPERADINEACETIC ACID ETHYL ESTER

2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER >98%

methyl 2-(4-piperidyl)acetate

methyl 2-piperidin-4-ylethanoate

2-(4-piperidinyl)acetic acid methyl ester

2-(4-piperidyl)acetic acid methyl ester

2-(Piperidin-4-yl)-acetic acid ethyl

59184-90-6

Piperidine