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ChemicalBook > CAS DataBase List > 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER

2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER

Uses
Product Name
2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER
CAS No.
59184-90-6
Chemical Name
2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER
Synonyms
ETHYL 4-PIPERIDINEACETATE;ETHYL 4-PIPERIDINYLACETATE;Ethyl 2-piperidin-4-ylacetate;methyl 2-(4-piperidyl)acetate;ETHYL 2-(4-PIPERIDINYL)ACETATE;4-piperidine Acetate Ethyl Ester;2-piperidine Acetate Ethyl Ester;methyl 2-piperidin-4-ylethanoate;PIPERIDINE-4-YL-ACETIC ETHYL ESTER;4-PIPERADINEACETIC ACID ETHYL ESTER
CBNumber
CB9281138
Molecular Formula
C9H17NO2
Formula Weight
171.24
MOL File
59184-90-6.mol
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2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Property

Melting point:
192 °C (decomp)
Boiling point:
67°C/0.22mm
Density 
0.969±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form 
liquid
pka
10.41±0.10(Predicted)
CAS DataBase Reference
59184-90-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
E926658
Product name
Ethyl2-(Piperidin-4-yl)acetate
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
127088
Product name
Ethyl2-(4-piperidinyl)acetate
Purity
>95%
Packaging
1g
Price
$81
Updated
2021/12/16
Matrix Scientific
Product number
127088
Product name
Ethyl2-(4-piperidinyl)acetate
Purity
>95%
Packaging
500mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-W7
Product name
Ethyl (piperidin-4-yl)acetate
Packaging
1g
Price
$24
Updated
2021/12/16
AK Scientific
Product number
W7206
Product name
2-(Piperidin-4-yl)-aceticacidethylester
Packaging
5g
Price
$134
Updated
2021/12/16
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2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

Piperidine derivatives have significant research value in the pharmaceutical field as drug intermediates. 4-Piperidine acetate methyl ester is also an important piperidine derivative drug intermediate, mainly used in the synthesis of drugs for various neurological diseases, such as convulsions, anti-epileptic drugs, and sedatives.

Synthesis

40110-55-2

59184-90-6

General procedure for the synthesis of ethyl 4-piperidineacetate from ethyl 2-(1-benzylpiperidin-4-ylidene)acetate: palladium/carbon catalyst (3.94 g) was added to a solution of 2-(1-benzylpiperidin-4-ylidene)ethyl acetate (24 g, 93 mmol) in ethyl acetate (300 mL). The reaction mixture was placed in an H-cubic hydrogenation reactor and the reaction conditions were set at 55 °C and 55 psi for 16 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford ethyl 4-piperidineacetate as a colorless oil (15 g, 90% yield). The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts δ: 4.10 (m, 2H), 3.03 (d, J = 16.4 Hz, 2H), 2.59 (t, J = 16.4 Hz, 2H), 2.19 (d, J = 9.6 Hz, 2H), 1.87 (m, 1H), 1.67 (d, J = 17.2 Hz, 2H ), 1.23 (t, J = 9.6Hz, 3H), 1.10 (m, 2H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 11, p. 3065 - 3067
[2] Patent: WO2013/107336, 2013, A1. Location in patent: Page/Page column 17; 18
[3] Patent: US2015/80380, 2015, A1. Location in patent: Paragraph 0081; 0137; 0138; 0139
[4] Synthetic Communications, 2003, vol. 33, # 13, p. 2329 - 2338

2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Suppliers

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View Lastest Price from 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER manufacturers

Shanghai CRM New Material Technology Co., LTD
Product
Ethyl 2-(piperidin-4-yl)acetate 59184-90-6
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
10t
Release date
2022-09-22
Career Henan Chemical Co
Product
2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER 59184-90-6
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

59184-90-6, 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTERRelated Search:

ETHYL 4-PIPERIDONE-3-CARBOXYLATE HYDROCHLORIDE 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER METHYL N-CBZ-3-PIPERIDINEACETATE METHYL 1-BOC-4-PIPERIDINEACETATE 3-METHOXYCARBONYLMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER PIPERIDIN-3-YL-ACETIC ACID ETHYL ESTER,2-(PIPERIDIN-3-YL)-ACETIC ACID ETHYL ESTER (R)-1-Boc-3-piperidineacetic acid methyl ester (R)-1-Cbz-3-Piperidineacetic Acid Methyl Ester Methylphenidate hydrochloride (S)-1-Boc-3-piperidineacetic acid methyl ester (S)-3-Piperidineacetic acid methyl ester hydrochloride PIPERIDIN-2-YL-ACETIC ACID ETHYL ESTER (S)-1-Cbz-3-Piperidineacetic Acid Methyl Ester PIPERIDIN-3-YL-ACETIC ACID ETHYL ESTER,2-(PIPERIDIN-3-YL)-ACETIC ACID ETHYL ESTER (R)-(3-TERT-BUTOXYCARBONYLAMINO-PIPERIDIN-2-YL)-ACETIC ACID ETHYL ESTER ETHYL 3-QUINUCLIDINECARBOXYLATE N-BENZOYLMEROQUINENE TERT-BUTYL ESTER ETHYL 4-PIPERIDINEACETATE HCL

  • PIPERIDIN-4-YL-ACETIC ACID ETHYL ESTER
  • PIPERIDINE-4-YL-ACETIC ETHYL ESTER
  • (Piperidin-4-yl)acetic acid ethyl ester, 4-(2-Ethoxy-2-oxoethyl)piperidine
  • Ethyl 2-(4-piperidinyl)acetate hydrochloride
  • 4-PIPERIDINE ACETIC ACID ETHYL ESTER
  • 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER
  • ETHYL 4-PIPERIDINEACETATE
  • ETHYL 2-(4-PIPERIDINYL)ACETATE
  • Ethyl 2-piperidin-4-ylacetate
  • 2-piperidine Acetate Ethyl Ester
  • 4-piperidine Acetate Ethyl Ester
  • ETHYL 4-PIPERIDINYLACETATE
  • 4-PIPERADINEACETIC ACID ETHYL ESTER
  • 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER >98%
  • methyl 2-(4-piperidyl)acetate
  • methyl 2-piperidin-4-ylethanoate
  • 2-(4-piperidinyl)acetic acid methyl ester
  • 2-(4-piperidyl)acetic acid methyl ester
  • 2-(Piperidin-4-yl)-acetic acid ethyl
  • 59184-90-6
  • Piperidine