2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER
Uses- Product Name
- 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER
- CAS No.
- 59184-90-6
- Chemical Name
- 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER
- Synonyms
- ETHYL 4-PIPERIDINEACETATE;ETHYL 4-PIPERIDINYLACETATE;Ethyl 2-piperidin-4-ylacetate;methyl 2-(4-piperidyl)acetate;ETHYL 2-(4-PIPERIDINYL)ACETATE;4-piperidine Acetate Ethyl Ester;2-piperidine Acetate Ethyl Ester;methyl 2-piperidin-4-ylethanoate;PIPERIDINE-4-YL-ACETIC ETHYL ESTER;4-PIPERADINEACETIC ACID ETHYL ESTER
- CBNumber
- CB9281138
- Molecular Formula
- C9H17NO2
- Formula Weight
- 171.24
- MOL File
- 59184-90-6.mol
2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Property
- Melting point:
- 192 °C (decomp)
- Boiling point:
- 67°C/0.22mm
- Density
- 0.969±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- liquid
- pka
- 10.41±0.10(Predicted)
- CAS DataBase Reference
- 59184-90-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- E926658
- Product name
- Ethyl2-(Piperidin-4-yl)acetate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4H23-1-W7
- Product name
- Ethyl (piperidin-4-yl)acetate
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 127088
- Product name
- Ethyl2-(4-piperidinyl)acetate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 127088
- Product name
- Ethyl2-(4-piperidinyl)acetate
- Purity
- >95%
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- W7206
- Product name
- 2-(Piperidin-4-yl)-aceticacidethylester
- Packaging
- 5g
- Price
- $134
- Updated
- 2021/12/16
2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
Piperidine derivatives have significant research value in the pharmaceutical field as drug intermediates. 4-Piperidine acetate methyl ester is also an important piperidine derivative drug intermediate, mainly used in the synthesis of drugs for various neurological diseases, such as convulsions, anti-epileptic drugs, and sedatives.
Synthesis
40110-55-2
59184-90-6
General procedure for the synthesis of ethyl 4-piperidineacetate from ethyl 2-(1-benzylpiperidin-4-ylidene)acetate: palladium/carbon catalyst (3.94 g) was added to a solution of 2-(1-benzylpiperidin-4-ylidene)ethyl acetate (24 g, 93 mmol) in ethyl acetate (300 mL). The reaction mixture was placed in an H-cubic hydrogenation reactor and the reaction conditions were set at 55 °C and 55 psi for 16 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford ethyl 4-piperidineacetate as a colorless oil (15 g, 90% yield). The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts δ: 4.10 (m, 2H), 3.03 (d, J = 16.4 Hz, 2H), 2.59 (t, J = 16.4 Hz, 2H), 2.19 (d, J = 9.6 Hz, 2H), 1.87 (m, 1H), 1.67 (d, J = 17.2 Hz, 2H ), 1.23 (t, J = 9.6Hz, 3H), 1.10 (m, 2H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 11, p. 3065 - 3067
[2] Patent: WO2013/107336, 2013, A1. Location in patent: Page/Page column 17; 18
[3] Patent: US2015/80380, 2015, A1. Location in patent: Paragraph 0081; 0137; 0138; 0139
[4] Synthetic Communications, 2003, vol. 33, # 13, p. 2329 - 2338
2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER Suppliers
- Tel
- --
- Fax
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- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
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View Lastest Price from 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER manufacturers
- Product
- Ethyl 2-(piperidin-4-yl)acetate 59184-90-6
- Price
- US $10.00-15.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10t
- Release date
- 2022-09-22
- Product
- 2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER 59184-90-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08