1-Boc-4-(2-hydroxyethyl)piperidine

Product Name: 1-Boc-4-(2-hydroxyethyl)piperidine
CAS No.: 89151-44-0
Chemical Name: 1-Boc-4-(2-hydroxyethyl)piperidine
Synonyms: tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate;Tirofiban Impurity 57;N-BOC-4-PIPERIDINEETHANOL;1-Boc-4-piperidineethanol;1-BOC-4-PIPERIDINE EHTANOL;BOC-2-(4-PIPERIDYL)ETHANOL;1-Boc-4-(hydroxyethyl)pip...;N-BOC-4-piperidine-β-ethanol;N-Boc-4-piperidineethanol 97%;N-Boc-4-piperidineethanol 97%
CBNumber: CB9449817
Molecular Formula: C12H23NO3
Formula Weight: 229.32
MOL File: 89151-44-0.mol

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1-Boc-4-(2-hydroxyethyl)piperidine Property

Boiling point:: 120-150 °C/0.5 mmHg (lit.)
Density: 1.043 g/mL at 25 °C (lit.)
refractive index: n20/D 1.4730(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: viscous liquid
pka: 15.10±0.10(Predicted)
color: Colourless to light yellow
InChI: InChI=1S/C12H23NO3/c1-12(2,3)16-11(15)13-7-4-10(5-8-13)6-9-14/h10,14H,4-9H2,1-3H3
InChIKey: YBNJZIDYXCGAPX-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(CCO)CC1
CAS DataBase Reference: 89151-44-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 547247
Product name: N-Boc-4-piperidineethanol
Purity: 97%
Packaging: 5g
Price: $58.58
Updated: 2025/07/31

Sigma-Aldrich

Product number: 547247
Product name: N-Boc-4-piperidineethanol
Purity: 97%
Packaging: 1g
Price: $30
Updated: 2023/06/20

TRC

Product number: B657230
Product name: N-BOC-4-piperidine-β-ethanol
Packaging: 10g
Price: $200
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-1-X3
Product name: 4-(2-Hydroxyethyl)piperidine, N-Boc protected
Packaging: 25g
Price: $136
Updated: 2021/12/16

Matrix Scientific

Product number: 069039
Product name: tert-Butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate
Purity: >95%
Packaging: 25g
Price: $145
Updated: 2021/12/16

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1-Boc-4-(2-hydroxyethyl)piperidine Chemical Properties,Usage,Production

Uses

N-BOC-4-piperidine-β-ethanol is used to prepare anilinoquinazoline VEGF receptor tyrosine kinase inhibitors with antitumor activities. It is also used to synthesize 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists with antiviral activities.

Synthesis

135716-08-4

89151-44-0

General procedure for the synthesis of N-Boc-4-piperidine ethanol from tert-butyl 4-(2-ethoxy-2-oxo-substituted)piperidine-1-carboxylate: first, the above product (639 mg, 2.4 mmol) was dissolved in 6 mL of methanol, protected by argon, replaced three times with hydrogen and reacted overnight in a hydrogenation unit (4 atm H2). Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and washed with ethyl acetate. The filtrate was concentrated and purified by column chromatography to give a white solid product (722 mg, 100% yield). Subsequently, the above product (506 mg, 1.9 mmol) was dissolved in 10 mL of ether, cooled to -20 °C, and hydrogenated diisobutylaluminum (1.0 M, 5 mL, 5 mmol) was slowly added, and the reaction was carried out for 10 min until the raw material completely disappeared. The reaction mixture was poured into saturated potassium sodium tartrate solution and stirred at room temperature for 3 hours until clarified. The aqueous phase was extracted three times with ether, the organic phases were combined, washed with saturated NaCl solution and dried over anhydrous Na2SO4. After concentration, the product was purified by column chromatography to give a white solid product (368 mg, 86% yield).

References

[1] Patent: CN102952072, 2016, B. Location in patent: Paragraph 0110-0111
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 13, p. 2167 - 2172
[3] Patent: US2012/71461, 2012, A1
[4] Patent: CN107793408, 2018, A
[5] Patent: WO2018/68297, 2018, A1

1-Boc-4-(2-hydroxyethyl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-4-(2-hydroxyethyl)piperidine Suppliers

China 220 Germany 1 India 3 Switzerland 1 United Kingdom 4 United States 24 Global 253

Suzhou Ningrui Pharmaceutical Co., Ltd

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Energy Chemical

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View Lastest Price from 1-Boc-4-(2-hydroxyethyl)piperidine manufacturers

Career Henan Chemical Co

Product: 1-Boc-4-(2-hydroxyethyl)piperidine 89151-44-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-06

Career Henan Chemical Co

Product: 1-Boc-4-(2-hydroxyethyl)piperidine 89151-44-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-09

89151-44-0, 1-Boc-4-(2-hydroxyethyl)piperidineRelated Search:

Diisobutyl phthalate 4-Hydroxybenzoic acid Butyl acetate 2-(METHYLSULFONYL)ETHANOL Isobutyl chloroformate Methylparaben Tris(trimethylsilyl)phosphate N-Methyldiethanolamine Haloperidol 2'-Hydroxy-3-phenylpropiophenone Salicylic acid 2-Butoxyethanol DROPERIDOL N-(tert-Butoxycarbonyl)-4-piperidone Buprofezin Butylparaben 4-Piperidineethanol Butyl acrylate

N-BOC-4-PIPERIDINEETHANOL

N-(TERT-BUTOXYCARBONYL)-4-PIPERIDINEETHANOL

1-BOC-4-(2-HYDROXYETHYL)PIPERIDINE

4-(2-HYDROXYETHYL)PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

BOC-2-(4-PIPERIDYL)ETHANOL

4-(2-Hydroxyethyl)piperidine, N-BOC protected

1-BOC-4-PIPERIDINE EHTANOL

1-PIPERIDINECARBOXYLIC ACID, 4-(2-HYDROXYETHYL)-1,

N-TERT-BUTOXYCARBONYL-4-PIPERIDINEETHANOL 95+%

tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate

Boc 4-(2-Hydroxyethyl)piperidine

1-Boc-4-(hydroxyethyl)piperidine

N-Boc-4-piperidineethanol,N-(tert-Butoxycarbonyl)-4-piperidineethanol

1-Boc-4-(hydroxyethyl)pip...

tert-Butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine

1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-, 1,1-diMethylethyl ester

N-Boc-4-piperidineethanol 97%

1-Boc-4-piperidineethanol

Tirofiban Impurity 57

N-BOC-4-piperidine-β-ethanol

N-Boc-4-(2-hydroxyethyl)piperidine

<i>N-</i>Boc-4-piperidineethanol

N-Boc-4-piperidineethanol 97%

89151-44-0

Building Blocks

Piperidines

Heterocyclic Building Blocks

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C12

Chemical Synthesis

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