ChemicalBook > CAS DataBase List > 1-Boc-4-(2-hydroxyethyl)piperidine

1-Boc-4-(2-hydroxyethyl)piperidine

Product Name
1-Boc-4-(2-hydroxyethyl)piperidine
CAS No.
89151-44-0
Chemical Name
1-Boc-4-(2-hydroxyethyl)piperidine
Synonyms
tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate;Tirofiban Impurity 57;N-BOC-4-PIPERIDINEETHANOL;1-Boc-4-piperidineethanol;1-BOC-4-PIPERIDINE EHTANOL;BOC-2-(4-PIPERIDYL)ETHANOL;1-Boc-4-(hydroxyethyl)pip...;N-BOC-4-piperidine-β-ethanol;N-Boc-4-piperidineethanol 97%;N-Boc-4-piperidineethanol 97%
CBNumber
CB9449817
Molecular Formula
C12H23NO3
Formula Weight
229.32
MOL File
89151-44-0.mol
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1-Boc-4-(2-hydroxyethyl)piperidine Property

Boiling point:
120-150 °C/0.5 mmHg (lit.)
Density 
1.043 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.4730(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
viscous liquid
pka
15.10±0.10(Predicted)
color 
Colourless to light yellow
InChI
InChI=1S/C12H23NO3/c1-12(2,3)16-11(15)13-7-4-10(5-8-13)6-9-14/h10,14H,4-9H2,1-3H3
InChIKey
YBNJZIDYXCGAPX-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(CCO)CC1
CAS DataBase Reference
89151-44-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
547247
Product name
N-Boc-4-piperidineethanol
Purity
97%
Packaging
5g
Price
$58.58
Updated
2025/07/31
Sigma-Aldrich
Product number
547247
Product name
N-Boc-4-piperidineethanol
Purity
97%
Packaging
1g
Price
$30
Updated
2023/06/20
TRC
Product number
B657230
Product name
N-BOC-4-piperidine-β-ethanol
Packaging
10g
Price
$200
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-1-X3
Product name
4-(2-Hydroxyethyl)piperidine, N-Boc protected
Packaging
25g
Price
$136
Updated
2021/12/16
Matrix Scientific
Product number
069039
Product name
tert-Butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate
Purity
>95%
Packaging
25g
Price
$145
Updated
2021/12/16
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1-Boc-4-(2-hydroxyethyl)piperidine Chemical Properties,Usage,Production

Uses

N-BOC-4-piperidine-β-ethanol is used to prepare anilinoquinazoline VEGF receptor tyrosine kinase inhibitors with antitumor activities. It is also used to synthesize 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists with antiviral activities.

Synthesis

135716-08-4

89151-44-0

General procedure for the synthesis of N-Boc-4-piperidine ethanol from tert-butyl 4-(2-ethoxy-2-oxo-substituted)piperidine-1-carboxylate: first, the above product (639 mg, 2.4 mmol) was dissolved in 6 mL of methanol, protected by argon, replaced three times with hydrogen and reacted overnight in a hydrogenation unit (4 atm H2). Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and washed with ethyl acetate. The filtrate was concentrated and purified by column chromatography to give a white solid product (722 mg, 100% yield). Subsequently, the above product (506 mg, 1.9 mmol) was dissolved in 10 mL of ether, cooled to -20 °C, and hydrogenated diisobutylaluminum (1.0 M, 5 mL, 5 mmol) was slowly added, and the reaction was carried out for 10 min until the raw material completely disappeared. The reaction mixture was poured into saturated potassium sodium tartrate solution and stirred at room temperature for 3 hours until clarified. The aqueous phase was extracted three times with ether, the organic phases were combined, washed with saturated NaCl solution and dried over anhydrous Na2SO4. After concentration, the product was purified by column chromatography to give a white solid product (368 mg, 86% yield).

References

[1] Patent: CN102952072, 2016, B. Location in patent: Paragraph 0110-0111
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 13, p. 2167 - 2172
[3] Patent: US2012/71461, 2012, A1
[4] Patent: CN107793408, 2018, A
[5] Patent: WO2018/68297, 2018, A1

1-Boc-4-(2-hydroxyethyl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Boc-4-(2-hydroxyethyl)piperidine manufacturers

Career Henan Chemical Co
Product
1-Boc-4-(2-hydroxyethyl)piperidine 89151-44-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2018-08-06
Career Henan Chemical Co
Product
1-Boc-4-(2-hydroxyethyl)piperidine 89151-44-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-08-09

89151-44-0, 1-Boc-4-(2-hydroxyethyl)piperidineRelated Search:

Diisobutyl phthalate 4-Hydroxybenzoic acid Butyl acetate 2-(METHYLSULFONYL)ETHANOL Isobutyl chloroformate Methylparaben Tris(trimethylsilyl)phosphate N-Methyldiethanolamine Haloperidol 2'-Hydroxy-3-phenylpropiophenone Salicylic acid 2-Butoxyethanol DROPERIDOL N-(tert-Butoxycarbonyl)-4-piperidone Buprofezin Butylparaben 4-Piperidineethanol Butyl acrylate

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  • 1-BOC-4-PIPERIDINE EHTANOL
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  • N-Boc-4-piperidineethanol,N-(tert-Butoxycarbonyl)-4-piperidineethanol
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  • tert-Butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine
  • 1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-, 1,1-diMethylethyl ester
  • N-Boc-4-piperidineethanol 97%
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  • Tirofiban Impurity 57
  • N-BOC-4-piperidine-β-ethanol
  • N-Boc-4-(2-hydroxyethyl)piperidine
  • <i>N-</i>Boc-4-piperidineethanol
  • N-Boc-4-piperidineethanol 97%
  • 89151-44-0
  • Building Blocks
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  • Chemical Synthesis
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