4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL
- Product Name
- 4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL
- CAS No.
- 162744-59-4
- Chemical Name
- 4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL
- Synonyms
- CAS:162744-59-4;RARECHEM AL BD 1306;4-bromo-2,6-difluorobenzyl;2,6-DIFLUORO-4-BROMOBENZYLALCOHOL;4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL;4-bromo-2,6-difluoro-benzenemethanol;(4-BROMO-2,6-DIFLUOROPHENYL)METHANOL;Benzenemethanol, 4-bromo-2,6-difluoro-
- CBNumber
- CB2493088
- Molecular Formula
- C7H5BrF2O
- Formula Weight
- 223.01
- MOL File
- 162744-59-4.mol
4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL Property
- Melting point:
- 76-81 °C (lit.)
- Boiling point:
- 250℃
- Density
- 1.744
- Flash point:
- 105℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- Solid
- pka
- 13.21±0.10(Predicted)
- color
- White to Light yellow
- InChIKey
- LSRHFWSNUFIKER-UHFFFAOYSA-N
- CAS DataBase Reference
- 162744-59-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 533033
- Product name
- 4-Bromo-2,6-difluorobenzyl alcohol
- Purity
- 98%
- Packaging
- 5g
- Price
- $56.63
- Updated
- 2025/07/31
- Product number
- B5090
- Product name
- 4-Bromo-2,6-difluorobenzyl Alcohol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- B5090
- Product name
- 4-Bromo-2,6-difluorobenzyl Alcohol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $156
- Updated
- 2025/07/31
- Product number
- B689758
- Product name
- 4-Bromo-2,6-difluorobenzyl alcohol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 2601-B-46
- Product name
- 4-Bromo-2,6-difluorobenzyl alcohol
- Packaging
- 10g
- Price
- $80
- Updated
- 2021/12/16
4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL Chemical Properties,Usage,Production
Uses
4-Bromo-2,6-difluorobenzyl alcohol is an organic intermediate. It has been reported that 4-bromo-2,6-difluorobenzyl alcohol can be used to prepare RET inhibitors.
Application
4-Bromo-2,6-difluorobenzyl alcohol can be used to prepare RET inhibitors.
Preparation
4-Bromo-2,6-difluorobenzyl alcohol can be obtained by reducing the carboxyl group from 4-bromo-3,5-difluorobenzoic acid.
Synthesis
183065-68-1
162744-59-4
General procedure for the synthesis of 4-bromo-2,6-difluorobenzenemethanol from 2,6-difluoro-4-bromobenzoic acid: to a solution of 2,6-difluoro-4-bromobenzoic acid (5 g, 21.10 mmol) in tetrahydrofuran (THF, 100 mL) was slowly added borane (BH3). Dimethyl sulfide (DMS, 20.03 mL, 211 mmol) was added dropwise at room temperature. The reaction mixture was stirred at 60 °C for 16 hours. After confirming complete consumption of the feedstock by liquid chromatography-mass spectrometry (LCMS) analysis, the reaction was quenched with methanol (MeOH). The solvent was evaporated under reduced pressure to afford 4-bromo-2,6-difluorobenzenemethanol as a white solid (4.5 g, 20.02 mmol, 95.2% yield), which could be used in subsequent reactions without further purification. Electrospray liquid chromatography-mass spectrometry (ES-LCMS) analysis showed m/z 222.1 ([M+H]+).
References
[1] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0371; 0372
[2] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 81; 82
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 10, p. 3258 - 3262
4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL Suppliers
- Tel
- --
- Fax
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- sales@riccichimica.com
- Country
- Italy
- ProdList
- 2146
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View Lastest Price from 4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL manufacturers
- Product
- 4-BROMO-2,6-DIFLUOROBENZYL ALCOHOL 162744-59-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-22
- Product
- (4-bromo-2,6-difluorophenyl)methanol 162744-59-4
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-01
- Product
- 4-BroMo-2,6-difluorobenzyl alcohol 162744-59-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-17