FOSMIDOMYCIN, SODIUM SALT

Product Name: FOSMIDOMYCIN, SODIUM SALT
CAS No.: 66508-37-0
Chemical Name: FOSMIDOMYCIN, SODIUM SALT
Synonyms: FR31564;fosmidomycin;phosphonamycin;antibioticfr31564;Fosmidomycin Sodium;FR-31564, SODIUM SALT;Fosmidomycinesodiumsalt;FOSMIDOMYCIN, SODIUM SALT;Fosmidomycin sodium salt (Synonyms: FR-31564);sodiuM hydrogen(3-(N-hydroxyforMaMido)propyl)phosphonate
CBNumber: CB2493341
Molecular Formula: C4H11NNaO5P
Formula Weight: 207.1
MOL File: 66508-37-0.mol

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FOSMIDOMYCIN, SODIUM SALT Property

Melting point:: 189-191°C
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form: Solid
color: White to Beige
Stability:: Hygroscopic

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-27-36/37/39-45

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16000
Product name: Fosmidomycin (sodium salt)
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16000
Product name: Fosmidomycin (sodium salt)
Purity: ≥95%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 16000
Product name: Fosmidomycin (sodium salt)
Purity: ≥95%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

Cayman Chemical

Product number: 16000
Product name: Fosmidomycin (sodium salt)
Purity: ≥95%
Packaging: 25mg
Price: $680
Updated: 2024/03/01

TRC

Product number: F728500
Product name: FosmidomycinSodiumSalt
Packaging: 50mg
Price: $900
Updated: 2021/12/16

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FOSMIDOMYCIN, SODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

White Powder

Uses

An antibiotic

Uses

The antibiotics Fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent antibacterial and antimalarial compounds.

Biological Activity

fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (dxp) [1]. fosmidomycin is an antibiotic originally isolated from bacteria of the genus streptomyces.1-deoxy-d-xylulose 5-phosphate reductoisomerase is an enzyme that interconverts dxp and 2-c-methyl-d-erythritol 4-phosphate (mep) [2].fosmidomycin was active against both gram-negative and gram-positive bacteria and the human malarial parasite p. falciparum with the ic50 of 290-370 nm[3]. fosmidomycin inhibited 1-deoxy-d-xylulose 5-phosphate reductoisomerase in an alternative nonmevalonate pathway for terpenoid biosynthesis with ic50 of 8.2 nm [1]. fosmidomycin has been shown to possess activity against plasmodium falciparum in vitro and in the mouse model. in patients with acute uncomplicated plasmodium falciparum malaria, oral administration of 1,200 mg fosmidomycin every 8 h for 7 days was effective in curing uncomplicated plasmodiumfalciparum malaria in humans [4]. fosmidomycin was an effective and safe antimalarial drug [4]. the treatment was well tolerated and showed a fast parasite and fever clearance [4].

References

[1] kuzuyama t, shimizu t, takahashi s, et al. fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis[j]. tetrahedron letters, 1998, 39(43): 7913-7916.
[2] takahashi s, kuzuyama t, watanabe h, et al. a 1-deoxy-d-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-c-methyl-d-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis[j]. proceedings of the national academy of sciences, 1998, 95(17): 9879-9884.
[3] jomaa h, wiesner j, sanderbrand s, et al. inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs[j]. science, 1999, 285(5433): 1573-1576.
[4] lell b, ruangweerayut r, wiesner j, et al. fosmidomycin, a novel chemotherapeutic agent for malaria[j]. antimicrobial agents and chemotherapy, 2003, 47(2): 735-738.

FOSMIDOMYCIN, SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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FOSMIDOMYCIN, SODIUM SALT Suppliers

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View Lastest Price from FOSMIDOMYCIN, SODIUM SALT manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Fosmidomycin Sodium Salt 66508-37-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: FOSMIDOMYCIN, SODIUM SALT 66508-37-0
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

66508-37-0, FOSMIDOMYCIN, SODIUM SALTRelated Search:

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3-(N-FORMYL-N-HYDROXYAMINO)PROPYL PHOSPHONIC ACID, SODIUM SALT

(3-(formylhydroxyamino)propyl)phosphonicacidmonosodiumsalt

(3-(formylhydroxyamino)propyl)-phosphonicacimonosodiumsalt

antibioticfr31564

fosmidomycin

Fosmidomycinesodiumsalt

3-(N-Formyl-N-hydroxyamino)propyl Phosphonic Acid, Sodium Salt, FR31564

FR31564

FR-31564, SODIUM SALT

FOSMIDOMYCIN, SODIUM SALT

[3-(Formylhydroxyamino)propyl]phosphonic acid sodium salt

Phosphonic acid, (3-(formylhydroxyamino)propyl)-, monosodium salt

sodiuM hydrogen(3-(N-hydroxyforMaMido)propyl)phosphonate

Fosmidomycin sodium salt (Synonyms: FR-31564)

phosphonamycin

Fosmidomycin Sodium

66508-37-0

C4H9NNaO5P

C4H9NO5PNa

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