FOSMIDOMYCIN, SODIUM SALT
- Product Name
- FOSMIDOMYCIN, SODIUM SALT
- CAS No.
- 66508-37-0
- Chemical Name
- FOSMIDOMYCIN, SODIUM SALT
- Synonyms
- FR31564;fosmidomycin;phosphonamycin;antibioticfr31564;Fosmidomycin Sodium;FR-31564, SODIUM SALT;Fosmidomycinesodiumsalt;FOSMIDOMYCIN, SODIUM SALT;Fosmidomycin sodium salt (Synonyms: FR-31564);sodiuM hydrogen(3-(N-hydroxyforMaMido)propyl)phosphonate
- CBNumber
- CB2493341
- Molecular Formula
- C4H11NNaO5P
- Formula Weight
- 207.1
- MOL File
- 66508-37-0.mol
FOSMIDOMYCIN, SODIUM SALT Property
- Melting point:
- 189-191°C
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
- form
- Solid
- color
- White to Beige
- Stability:
- Hygroscopic
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-27-36/37/39-45
N-Bromosuccinimide Price
- Product number
- 16000
- Product name
- Fosmidomycin (sodium salt)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 16000
- Product name
- Fosmidomycin (sodium salt)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 16000
- Product name
- Fosmidomycin (sodium salt)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- 16000
- Product name
- Fosmidomycin (sodium salt)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $680
- Updated
- 2024/03/01
- Product number
- F728500
- Product name
- FosmidomycinSodiumSalt
- Packaging
- 50mg
- Price
- $900
- Updated
- 2021/12/16
FOSMIDOMYCIN, SODIUM SALT Chemical Properties,Usage,Production
Chemical Properties
White Powder
Uses
An antibiotic
Uses
The antibiotics Fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent antibacterial and antimalarial compounds.
Biological Activity
fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (dxp) [1]. fosmidomycin is an antibiotic originally isolated from bacteria of the genus streptomyces.1-deoxy-d-xylulose 5-phosphate reductoisomerase is an enzyme that interconverts dxp and 2-c-methyl-d-erythritol 4-phosphate (mep) [2].fosmidomycin was active against both gram-negative and gram-positive bacteria and the human malarial parasite p. falciparum with the ic50 of 290-370 nm[3]. fosmidomycin inhibited 1-deoxy-d-xylulose 5-phosphate reductoisomerase in an alternative nonmevalonate pathway for terpenoid biosynthesis with ic50 of 8.2 nm [1]. fosmidomycin has been shown to possess activity against plasmodium falciparum in vitro and in the mouse model. in patients with acute uncomplicated plasmodium falciparum malaria, oral administration of 1,200 mg fosmidomycin every 8 h for 7 days was effective in curing uncomplicated plasmodiumfalciparum malaria in humans [4]. fosmidomycin was an effective and safe antimalarial drug [4]. the treatment was well tolerated and showed a fast parasite and fever clearance [4].
in vivo
Animals treated intraperitoneally with dosages of >10 mg/kg of fosmidomycin are apparently free of parasites. After treatment with 5 mg/kg of fosmidomycin, parasitemias are <1%. Animals treated orally with 50 or 100 mg/kg of fosmidomycin are apparently free of parasites, and parasitemias are <1% after treatment with 20 mg/kg of drug. Recrudescence is observed when the treatment is terminated after 4 days. Mice treated with 30 mg/kg of fosmidomycin over a period of 8 days are totally cured[3].
References
[1] kuzuyama t, shimizu t, takahashi s, et al. fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis[j]. tetrahedron letters, 1998, 39(43): 7913-7916.
[2] takahashi s, kuzuyama t, watanabe h, et al. a 1-deoxy-d-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-c-methyl-d-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis[j]. proceedings of the national academy of sciences, 1998, 95(17): 9879-9884.
[3] jomaa h, wiesner j, sanderbrand s, et al. inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs[j]. science, 1999, 285(5433): 1573-1576.
[4] lell b, ruangweerayut r, wiesner j, et al. fosmidomycin, a novel chemotherapeutic agent for malaria[j]. antimicrobial agents and chemotherapy, 2003, 47(2): 735-738.
FOSMIDOMYCIN, SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
FOSMIDOMYCIN, SODIUM SALT Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7778
- Advantage
- 56
- Tel
- 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15873
- Advantage
- 55
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 14948
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29798
- Advantage
- 58
- Tel
- 0571-89903882 18679456698
- mingxinzhu@huidabiotech.com
- Country
- China
- ProdList
- 2975
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 0757-85921206 18520245316
- 2329783215@qq.com
- Country
- China
- ProdList
- 12661
- Advantage
- 58
- Tel
- 0571-0571-89903882 15990081639
- sunshixuan@huidabiotech.com
- Country
- China
- ProdList
- 3705
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 17717235263
- cindy.yang@lgcgroup.com
- Country
- China
- ProdList
- 18003
- Advantage
- 58
- Tel
- 4001-009266 17349750668
- product@sci-e.com
- Country
- China
- ProdList
- 2808
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 18136139868; 18136139868
- jinlun@goodchemtech.cn
- Country
- China
- ProdList
- 284
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9835
- Advantage
- 58
- Tel
- 400-821-026
- Sales@sangon.com
- Country
- China
- ProdList
- 6710
- Advantage
- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- 400-025-6535
- sales@adooq.cn
- Country
- China
- ProdList
- 6215
- Advantage
- 58
- Tel
- 021-60936350
- scbt@scbt.com
- Country
- China
- ProdList
- 6594
- Advantage
- 58
- Tel
- +8613817748580
- Fax
- 021-50175322
- cooperation@kean-chem.com
- Country
- China
- ProdList
- 40066
- Advantage
- 58
- Tel
- +8618791163155
- 18791163155@163.com
- Country
- China
- ProdList
- 3397
- Advantage
- 58
- Tel
- +86-18621343501; +undefined18621343501
- product@acmec-e.com
- Country
- China
- ProdList
- 33338
- Advantage
- 58
- Tel
- 17765276361
- Country
- CHINA
- ProdList
- 109
- Advantage
- 58
- Tel
- 13763000060
- Country
- CHINA
- ProdList
- 161
- Advantage
- 58
- Tel
- 15625080345
- Country
- CHINA
- ProdList
- 104
- Advantage
- 58
- Tel
- 020-83808789
- Country
- CHINA
- ProdList
- 179
- Advantage
- 58
- Tel
- 15356162092
- Country
- CHINA
- ProdList
- 141
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@biorbyt.com
- Country
- CHINA
- ProdList
- 6482
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@neobioscience.com
- Country
- CHINA
- ProdList
- 6207
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- 470003480@QQ.COM
- Country
- CHINA
- ProdList
- 6955
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6502
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- lyn@biopike.com.cn
- Country
- CHINA
- ProdList
- 6646
- Advantage
- 58
- Tel
- --
- Fax
- --
- jijinhuaxue@sina.com
- Country
- CHINA
- ProdList
- 6606
- Advantage
- 58
- Tel
- --
- Fax
- --
- 2453006496@qq.com
- Country
- CHINA
- ProdList
- 6184
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1787309105@qq.com
- Country
- CHINA
- ProdList
- 3872
- Advantage
- 58
- Tel
- --
- Fax
- --
- service@neobioscience.com
- Country
- CHINA
- ProdList
- 6151
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1914109725@qq.com
- Country
- CHINA
- ProdList
- 6518
- Advantage
- 58
View Lastest Price from FOSMIDOMYCIN, SODIUM SALT manufacturers
- Product
- Fosmidomycin Sodium Salt 66508-37-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- FOSMIDOMYCIN, SODIUM SALT 66508-37-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25