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FOSMIDOMYCIN, SODIUM SALT

Product Name
FOSMIDOMYCIN, SODIUM SALT
CAS No.
66508-37-0
Chemical Name
FOSMIDOMYCIN, SODIUM SALT
Synonyms
FR31564;fosmidomycin;phosphonamycin;antibioticfr31564;Fosmidomycin Sodium;FR-31564, SODIUM SALT;Fosmidomycinesodiumsalt;FOSMIDOMYCIN, SODIUM SALT;Fosmidomycin sodium salt (Synonyms: FR-31564);sodiuM hydrogen(3-(N-hydroxyforMaMido)propyl)phosphonate
CBNumber
CB2493341
Molecular Formula
C4H11NNaO5P
Formula Weight
207.1
MOL File
66508-37-0.mol
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FOSMIDOMYCIN, SODIUM SALT Property

Melting point:
189-191°C
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form 
Solid
color 
White to Beige
Stability:
Hygroscopic
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-45
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16000
Product name
Fosmidomycin (sodium salt)
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16000
Product name
Fosmidomycin (sodium salt)
Purity
≥95%
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
16000
Product name
Fosmidomycin (sodium salt)
Purity
≥95%
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
16000
Product name
Fosmidomycin (sodium salt)
Purity
≥95%
Packaging
25mg
Price
$680
Updated
2024/03/01
TRC
Product number
F728500
Product name
FosmidomycinSodiumSalt
Packaging
50mg
Price
$900
Updated
2021/12/16
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FOSMIDOMYCIN, SODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

White Powder

Uses

An antibiotic

Uses

The antibiotics Fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent antibacterial and antimalarial compounds.

Biological Activity

fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (dxp) [1]. fosmidomycin is an antibiotic originally isolated from bacteria of the genus streptomyces.1-deoxy-d-xylulose 5-phosphate reductoisomerase is an enzyme that interconverts dxp and 2-c-methyl-d-erythritol 4-phosphate (mep) [2].fosmidomycin was active against both gram-negative and gram-positive bacteria and the human malarial parasite p. falciparum with the ic50 of 290-370 nm[3]. fosmidomycin inhibited 1-deoxy-d-xylulose 5-phosphate reductoisomerase in an alternative nonmevalonate pathway for terpenoid biosynthesis with ic50 of 8.2 nm [1]. fosmidomycin has been shown to possess activity against plasmodium falciparum in vitro and in the mouse model. in patients with acute uncomplicated plasmodium falciparum malaria, oral administration of 1,200 mg fosmidomycin every 8 h for 7 days was effective in curing uncomplicated plasmodiumfalciparum malaria in humans [4]. fosmidomycin was an effective and safe antimalarial drug [4]. the treatment was well tolerated and showed a fast parasite and fever clearance [4].

References

[1] kuzuyama t, shimizu t, takahashi s, et al. fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis[j]. tetrahedron letters, 1998, 39(43): 7913-7916.
[2] takahashi s, kuzuyama t, watanabe h, et al. a 1-deoxy-d-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-c-methyl-d-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis[j]. proceedings of the national academy of sciences, 1998, 95(17): 9879-9884.
[3] jomaa h, wiesner j, sanderbrand s, et al. inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs[j]. science, 1999, 285(5433): 1573-1576.
[4] lell b, ruangweerayut r, wiesner j, et al. fosmidomycin, a novel chemotherapeutic agent for malaria[j]. antimicrobial agents and chemotherapy, 2003, 47(2): 735-738.

FOSMIDOMYCIN, SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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FOSMIDOMYCIN, SODIUM SALT Suppliers

Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from FOSMIDOMYCIN, SODIUM SALT manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Fosmidomycin Sodium Salt 66508-37-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
FOSMIDOMYCIN, SODIUM SALT 66508-37-0
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

66508-37-0, FOSMIDOMYCIN, SODIUM SALTRelated Search:


  • 3-(N-FORMYL-N-HYDROXYAMINO)PROPYL PHOSPHONIC ACID, SODIUM SALT
  • (3-(formylhydroxyamino)propyl)phosphonicacidmonosodiumsalt
  • (3-(formylhydroxyamino)propyl)-phosphonicacimonosodiumsalt
  • antibioticfr31564
  • fosmidomycin
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  • 3-(N-Formyl-N-hydroxyamino)propyl Phosphonic Acid, Sodium Salt, FR31564
  • FR31564
  • FR-31564, SODIUM SALT
  • FOSMIDOMYCIN, SODIUM SALT
  • [3-(Formylhydroxyamino)propyl]phosphonic acid sodium salt
  • Phosphonic acid, (3-(formylhydroxyamino)propyl)-, monosodium salt
  • sodiuM hydrogen(3-(N-hydroxyforMaMido)propyl)phosphonate
  • Fosmidomycin sodium salt (Synonyms: FR-31564)
  • phosphonamycin
  • Fosmidomycin Sodium
  • 66508-37-0
  • C4H9NNaO5P
  • C4H9NO5PNa
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