CK2 INHIBITOR II
- Product Name
- CK2 INHIBITOR II
- CAS No.
- 749234-11-5
- Chemical Name
- CK2 INHIBITOR II
- Synonyms
- DMAT >=98% (HPLC);DMAT(CK2 Inhibitor);DMAT, 10 mM in DMSO;inhibit,Casein Kinase,DMAT,Inhibitor;Thymidine 3',5'-diphosphate tetrasodium;CASEIN KINASE II INHIBITOR;CK2 INHIBITOR;2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole;4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine;1H-Benzimidazol-2-amine, 4,5,6,7-tetrabromo-N,N-dimethyl-;4,5,6,7-tetrabroMo-N,N-diMethyl-1H-benzo[d]iMidazol-2-aMine
- CBNumber
- CB2497369
- Molecular Formula
- C9H7Br4N3
- Formula Weight
- 476.79
- MOL File
- 749234-11-5.mol
CK2 INHIBITOR II Property
- Melting point:
- >330℃ (Decomposition)
- Boiling point:
- 497.7±55.0 °C(Predicted)
- Density
- 2.410±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥23.85 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- solid
- pka
- 4.55±0.30(Predicted)
- color
- White to off-white
- InChI
- 1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15)
- InChIKey
- SLPJGDQJLTYWCI-UHFFFAOYSA-N
- SMILES
- CN(C)c1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2044
- Product name
- DMAT
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $80.3
- Updated
- 2025/07/31
- Product number
- SML2044
- Product name
- DMAT
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $326
- Updated
- 2025/07/31
- Product number
- 21182
- Product name
- DMAT
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 21182
- Product name
- DMAT
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 21182
- Product name
- DMAT
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
CK2 INHIBITOR II Chemical Properties,Usage,Production
Description
DMAT is a cell-permeable inhibitor of casein kinase 2 (CK2; IC50 = 0.13 μM). It also inhibits Pim-1, Pim-3, HIPK2, and HIPK3 (IC50s = 0.15, 0.097, 0.37, and 0.59 μM, respectively). DMAT blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts.
Uses
2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole is a novel powerful and selective inhibitor of protein kinase CK2.
in vivo
DMAT application in vivo reduces tumor growth in a xenotransplant model by interference with tumor cell proliferation. Biochemical parameters and histology following DMAT administration revealed no alterations in liver tissue[4].
IC 50
CK2: 0.13 μM (IC50, Human CK2); PIM1: 0.148 μM (IC50); PIM2: 1.6 μM (IC50); PIM3: 0.097 μM (IC50); HIPK2: 0.37 μM (IC50); HIPK3: 0.59 μM (IC50); DYRK1a: 0.41 μM (IC50); DYRK2: 0.35 μM (IC50); DYRK3: 1.7 μM (IC50); PKD1: 0.18 μM (IC50); CDK2: 0.64 μM (IC50)
References
[1] MARIO A PAGANO. The selectivity of inhibitors of protein kinase CK2: an update.[J]. Biochemical Journal, 2008: 353-365. DOI: 10.1042/bj20080309
[2] HANNA LAWNICKA. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro.[J]. Cell and Tissue Research, 2010, 340 2: 371-379. DOI: 10.1007/s00441-010-0960-1
[3] GABRIELE SASS. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT.[J]. International journal of oncology, 2011, 39 2: 433-442. DOI: 10.3892/ijo.2011.1037
[4] CHRISTINA WESTMOSE YDE . Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT[J]. Cancer letters, 2007, 256 2: Pages 229-237. DOI: 10.1016/j.canlet.2007.06.010
CK2 INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
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