CK2 INHIBITOR II Property

Melting point:

>330℃ (Decomposition)

Boiling point:

497.7±55.0 °C(Predicted)

Density 

2.410±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

≥23.85 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

form 

solid

pka

4.55±0.30(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

CK2 INHIBITOR II Chemical Properties,Usage,Production

Description

DMAT is a cell-permeable inhibitor of casein kinase 2 (CK2; IC₅₀ = 0.13 μM). It also inhibits Pim-1, Pim-3, HIPK2, and HIPK3 (IC₅₀s = 0.15, 0.097, 0.37, and 0.59 μM, respectively). DMAT blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts.

Uses

2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole is a novel powerful and selective inhibitor of protein kinase CK2.