APROBARBITAL METHANOL SOLUTION

Product Name
APROBARBITAL METHANOL SOLUTION
CAS No.
77-02-1
Chemical Name
APROBARBITAL METHANOL SOLUTION
Synonyms
Numal;Isonal;Aprozal;Allonal;Alurate;Allional;NSC120769;Aprobarbita;Allypropymal;Aprobarbitone
CBNumber
CB2497884
Molecular Formula
C10H14N2O3
Formula Weight
210.23
MOL File
77-02-1.mol
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APROBARBITAL METHANOL SOLUTION Property

Melting point:
140-141.5°
Boiling point:
349.75°C (rough estimate)
Density 
1.2056 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
7.81±0.10(Predicted)
color 
White to Off-White
Water Solubility 
4.121g/L(25 ºC)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/25-36/38
Safety Statements 
16-24-45
Hazardous Substances Data
77-02-1(Hazardous Substances Data)
Toxicity
LD50 i.p. in mice: 200 mg/kg (Frey)
DEA Controlled Substances
CSCN: 2100
CSA SCH: Schedule III
NARC: No
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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APROBARBITAL METHANOL SOLUTION Chemical Properties,Usage,Production

Originator

Alurate,Roche

Uses

Controlled substance (depressant). Sedative, hypnotic.

Definition

ChEBI: A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by an isopropyl and a prop-1-en-3-yl group at position 5.

Manufacturing Process

170 parts of isopropylbarbituric acid are mixed with 500 parts of water and dissolved by adding 135 parts of a 30 percent of the solution of sodium hydroxide. To this solution are added 130 parts of 130 parts of allylbromide. An emulsion obtained is stirred at an inner temperature of about 25°C. The reaction is at first accompanied by a slight development of heat. After 12 hours the reaction is brought to a close. When cooled down the isopropylallylbarbituric acid is drawn off. The yield is more than 80 percent of the theoretically calculated quantity. By crystallization from diluted alcohol the pure isopropylallylbarbituric acid is obtained in colorless crystals of the melting point 137-138°C.

Therapeutic Function

Sedative, Hypnotic

World Health Organization (WHO)

Aprobarbital is an intermediate-acting barbiturate. See WHO comment for barbiturates.

APROBARBITAL METHANOL SOLUTION Preparation Products And Raw materials

Raw materials

Preparation Products

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APROBARBITAL METHANOL SOLUTION Suppliers

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77-02-1, APROBARBITAL METHANOL SOLUTIONRelated Search:

5-(2-bromoallyl)-5-(1-methylpropyl)-1H,3H,5H-pyrimidine-2,4,6-trione methohexital sodium SECOBARBITAL 5-ISOPROPYLBARBITURIC ACID Narcobarbital Methohexital APROBARBITAL METHANOL SOLUTION BARBITAL Barbituric acid Probarbital SECOBARBITAL-D5 (1-METHYL-D3, BUTYL-2,2-D2) (R)-(+)-Seconal S(-)-Secobarbital sodium 5-allyl-5-isopropylbarbiturate R(+)-Secobarbital sodium S(-)-Secobarbital sodium TALBUTAL CIII (250 MG) CYCLOPENTOBARBITAL

  • Allopropylbarbital
  • alurateelixirverdum
  • Aprobarbita
  • Aprobarbitone
  • Aprozal
  • Isonal
  • isonal(swedish)
  • Isopropylallylbarbituric acid
  • isopropylallylbarbituricacid
  • Numal
  • Propallylonal M (des-Br)
  • APROBARBITAL METHANOL SOLUTION
  • 5-Ally-5-isopropyl barbituric acid
  • allyisopropyl-barbituric acid
  • Aprobarbital (base and/or unspecified salts)
  • Aprobarbital CIII (200 mg) (AS) DISCONTINUED
  • 5-(1-Methylethyl)-5-(2-propen-1-yl)-2,4,6(1H,3H,5H)-pyriMidinetrione
  • NSC120769
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propenyl)-
  • 6(1h,3h,5h)-pyrimidinetrione,5-(1-methylethyl)-5-(2-propenyl)-4
  • Allional
  • Allonal
  • Allylisopropylbarbituric acid
  • allylisopropylbarbituricacid
  • Allylisopropylmalonylurea
  • Allylpropymal
  • Allypropymal
  • Alurate
  • Alurate Elixir Verdum
  • 5-(1-methylethyl)-5-(2-propenyl)-2,4,6(1h,3h,5h)-pyrimidinetrione
  • 5-Allyl-5-isopropyl-2,4,6(1H,3H,5H)-pyrimidinetrione
  • 5-Allyl-5-isopropylbarbiturate
  • 5-Allyl-5-isopropylbarbituric acid
  • 5-allyl-5-isopropyl-barbituricaci
  • 5-allyl-5-isopropylbarbituricacid
  • 5-Isopropyl-5-allylbarbituric acid
  • 5-isopropyl-5-allylbarbituricacid
  • Aprobarbital Solution, 100ppm
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propen-1-yl)-
  • 77-02-1
  • C3H5C3H7C4H2N2O3
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals