3-(METHYLSULFONYL)ANILINE

Product Name: 3-(METHYLSULFONYL)ANILINE
CAS No.: 35216-39-8
Chemical Name: 3-(METHYLSULFONYL)ANILINE
Synonyms: m-(Methylsulfonyl)aniline;3-(Methylsulphonyl)aniline;3-Methylsulfonylphenylamine;P-Toluene Suphonamide (PTSA);3-Aminophenyl methyl sulfone;3-(methylsulfonyl)Benzenamine;3-Aminophenyl methyl sulphone;Benzenamine, 3-(methylsulfonyl)-
CBNumber: CB2500645
Molecular Formula: C7H9NO2S
Formula Weight: 171.22
MOL File: 35216-39-8.mol

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3-(METHYLSULFONYL)ANILINE Property

Melting point:: 72 °C
Boiling point:: 165-170 °C(Press: 0.3 Torr)
Density: 1.282±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: 2.66±0.10(Predicted)
color: Light red

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Safety

HS Code: 2921420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M218785
Product name: 3-(Methanesulfonyl)aniline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M218785
Product name: 3-(Methanesulfonyl)aniline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 127742
Product name: 3-(Methylsulphonyl)aniline
Purity: >95%
Packaging: 500mg
Price: $134
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8663-1-Z6
Product name: 3-(Methylsulfonyl)aniline
Packaging: 1g
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8663-1-Z6
Product name: 3-(Methylsulfonyl)aniline
Packaging: 5G
Price: $176
Updated: 2021/12/16

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3-(METHYLSULFONYL)ANILINE Chemical Properties,Usage,Production

Uses

3-(Methylsulfonyl)aniline is used in the preparation of substituted pyrazolopyrimidines as IRAK4 kinase inhibitors.

Synthesis

1783-81-9

35216-39-8

General procedure for the synthesis of 3-methylsulfonylaniline from 3-aminothioanisole: A mixture of Na2WO4 (0.067 g), 1 drop of acetic acid and H2O (5 mL) was added to a flask and heated to 65 °C. Subsequently, 3-methylthioaniline (500 mg, 3.59 mmol) was added and H2O2 (1.1 mL, 10.77 mmol) was added slowly and dropwise. The reaction mixture was stirred at 65 °C for 1.5 hours. After completion of the reaction, it was cooled to room temperature and extracted by adding 1N HCl (80 mL) and DCM (50 mL). The organic and aqueous phases were separated and the aqueous phase was then washed with DCM. The aqueous phase was alkalized with 25% NaOH solution and extracted with DCM. The organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure to give the 3-methylsulfonylaniline derivative.Preparation of 3-(methylsulfonyl)aniline (158): Compound 158 was prepared from 3-methylsulfonylaniline (153) according to Method E. 557 mg of brown powder was obtained in 92% yield.1H NMR (500 MHz, CDCl3) δ 3.03 (s, 3H), 6.89 (ddd, J = 0.8, 2.3, 8.0 Hz, 1H), 7.21 (t, J = 2.1 Hz, 1H), 7.24 (dt, J = 1.1, 7.7 Hz, 1H), 7.30 (t, J = 7.8 Hz, 1H). 13C NMR (126 MHz, CDCl3) δ 44.40, 112.69, 116.37, 119.72, 130.30, 141.16, 141.16. 130.30, 141.16, 147.69. LC-MS (M+H+) calculated value C7H9NO2S 172, measured value 172.

References

[1] Patent: WO2014/100833, 2014, A1. Location in patent: Paragraph 0080; 0232
[2] Patent: WO2007/60026, 2007, A1. Location in patent: Page/Page column 49-50
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 18, p. 4741 - 4745

3-(METHYLSULFONYL)ANILINE Preparation Products And Raw materials

Raw materials

Hexane Ethanol Potassium hydroxide Sodium chloride Ammonium chloride Ethyl acetate Sodium bicarbonate Nitric acid Iron Methyl phenyl sulfone

Preparation Products

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3-(METHYLSULFONYL)ANILINE Suppliers

China 62 India 2 United Kingdom 1 United States 8 Global 73

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View Lastest Price from 3-(METHYLSULFONYL)ANILINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(METHYLSULFONYL)ANILINE 35216-39-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-16

Career Henan Chemical Co

Product: 3-(METHYLSULFONYL)ANILINE 35216-39-8
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

35216-39-8, 3-(METHYLSULFONYL)ANILINERelated Search:

1-Chloro-4-(ethylsulfonyl)-2-nitrobenzene 3,3'-Sulfonyldianiline 2-[(3-Aminophenyl) Sulfonyl)Ethanol 3,3'-Diamino-4,4'-dihydroxydiphenyl sulfone bis(4-chloro-3-nitrophenyl) sulphone 4-METHYLSULFONYL-2-NITROFLUOROBENZENE 2-METHANESULFONYL-4-NITROPHENYLAMINE 3,6-THIOXANTHENEDIAMINE-10,10-DIOXIDE O-TOLIDINE SULFONE 4-Chloro-3-nitrophenyl methyl sulfone 2-Nitro-4-methylsulfonyltoluene REACTIVE BLACK 5 3-Nitrophenyl sulphone BIS(4-FLUORO-3-NITROPHENYL) SULFONE 3,3'-DIAZIDODIPHENYL SULFONE 2-AMINO-4-(ETHYLSULFONYL)PHENOL UNIBLUE A SODIUM SALT LUCIFER YELLOW VS DILITHIUM SALT

3-Aminophenyl methyl sulphone

3-(methylsulfonyl)Benzenamine

m-(Methylsulfonyl)aniline

3-Aminophenyl methyl sulfone

3-Methylsulfonylphenylamine

P-Toluene Suphonamide (PTSA)

3-(Methylsulphonyl)aniline

Benzenamine, 3-(methylsulfonyl)-

35216-39-8