CORALYNE CHLORIDE HYDRATE, 98+%

CORALYNE CHLORIDE HYDRATE, 98+% Property

Melting point:

215°C

storage temp. 

2-8°C

solubility 

DMSO:5.0(Max Conc. mg/mL);12.5(Max Conc. mM)
Water:5.0(Max Conc. mg/mL);12.5(Max Conc. mM)

form 

Solid

color 

Light yellow to yellow

Safety

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-25

Safety Statements 

26-36-45

RTECS 

HQ1812000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

CORALYNE CHLORIDE HYDRATE, 98+% Chemical Properties,Usage,Production

Chemical Properties

orange crystalline powder

Uses

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes[3].

IC 50

Topoisomerase I

References

[1] Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445. DOI:10.1016/j.biopha.2017.04.027
[2] D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4(6):781-91. DOI:10.1016/0968-0896(96)00054-5
[3] P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7(18):10660-10667. DOI:10.1039/c6ra27684a