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Methenamine hippurate

Product Name
Methenamine hippurate
CAS No.
5714-73-8
Chemical Name
Methenamine hippurate
Synonyms
r-657;D00855;hiprex;haiprex;Urex (tn);cane(1:1);hippramine;Hiprex (tn);Methenamine hippurate;METHENAMINEHIPPURATE,USP
CBNumber
CB2501374
Molecular Formula
C15H21N5O3
Formula Weight
319.37
MOL File
5714-73-8.mol
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Methenamine hippurate Property

Melting point:
89-95°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
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Safety

HS Code 
2933690000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24004
Product name
Methenamine Hippurate
Purity
≥98%
Packaging
100mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
24004
Product name
Methenamine Hippurate
Purity
≥98%
Packaging
250mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
24004
Product name
Methenamine Hippurate
Purity
≥98%
Packaging
500mg
Price
$220
Updated
2024/03/01
TRC
Product number
M226025
Product name
MethenamineHippurate
Packaging
1g
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0013675
Product name
Methenamine(hippurate)
Packaging
250mg
Price
$120
Updated
2021/12/16
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Methenamine hippurate Chemical Properties,Usage,Production

Description

Methenamine hippurate is a broad-spectrum urinary antiseptic agent. Under acidic conditions, methenamine hippurate is hydrolyzed to formaldehyde and ammonia, which exerts an antibacterial effect. It is effective against a wide range of bacteria but lacks activity against Proteus and other bacteria that increase urine alkalinity. Formulations containing methenamine hippurate have been used to treat urinary tract infections.

Chemical Properties

White Solid

Originator

Hiprex ,Merrell National,US,1967

Uses

Antibacterial (urinary).

Definition

ChEBI: Methenamine hippurate is a N-acylglycine. It is functionally related to a N-benzoylglycine.

Manufacturing Process

179 g (1 mol) hippuric acid (benzoyl glycine) and 140 g (1 mol) hexamethylenetetramine were heated under reflux in 500 ml methanol. The small amount of water necessary to give a clear, homogeneous solution was added to the resulting reaction mixture which was then evaporated to dryness. The residue soon crystallized, a procedure that could be greatly accelerated by seeding with crystals of hexamethylenetetramine hippurate from a previous preparation. The resulting solid product was broken up and pulverized. Hexamethylenetetramine hippurate is stable on exposure to air and is soluble in water and alcohol. It melts at 105° to 110°C.

brand name

Urex(Vatring).

Therapeutic Function

Antibacterial (urinary)

General Description

Methenamine hippurate (Hiprex) is the hippuric acid salt ofmethenamine. It is readily absorbed after oral administrationand is concentrated in the urinary bladder, where it exerts itsantibacterial activity. Its activity is increased in acid urine.

Clinical Use

Antibacterial agent

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: increased risk of crystalluria with sulphonamides.
Diuretics: effects antagonised by acetazolamide.

Metabolism

Under acid conditions methenamine is slowly hydrolysed to formaldehyde and ammonia. Almost no hydrolysis of methenamine takes place at physiological pH, and it is therefore virtually inactive in the body. Methenamine is rapidly and almost completely eliminated in the urine, and provided this is acidic (preferably below pH 5.5) bactericidal concentrations of formaldehyde occur. Because of the time taken for hydrolysis, however, these do not occur until the urine reaches the bladder.

Methenamine hippurate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methenamine hippurate Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Tianjin Derchemist Science & Technology Co., Ltd.
Tel
22-58627059 13920586291
Fax
022-58620305
Email
zdcomcon@126.com
Country
China
ProdList
2918
Advantage
50
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16687
Advantage
50
Shanghai Synchem Pharma Co., ltd
Tel
021-61984905-1 18016477331
Email
synchempharma@aliyun.com
Country
China
ProdList
6451
Advantage
55
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5877
Advantage
65
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
Advantage
58
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View Lastest Price from Methenamine hippurate manufacturers

Dideu Industries Group Limited
Product
Methenamine hippurate 5714-73-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-22
Shaanxi Dideu Medichem Co. Ltd
Product
Methenamine hippurate 5714-73-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
600 Tons
Release date
2020-05-03

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