Methenamine hippurate
- Product Name
- Methenamine hippurate
- CAS No.
- 5714-73-8
- Chemical Name
- Methenamine hippurate
- Synonyms
- r-657;D00855;hiprex;haiprex;Urex (tn);cane(1:1);hippramine;Hiprex (tn);Methenamine hippurate;METHENAMINEHIPPURATE,USP
- CBNumber
- CB2501374
- Molecular Formula
- C15H21N5O3
- Formula Weight
- 319.37
- MOL File
- 5714-73-8.mol
Methenamine hippurate Property
- Melting point:
- 89-95°C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
Safety
- HS Code
- 2933690000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 24004
- Product name
- Methenamine Hippurate
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 24004
- Product name
- Methenamine Hippurate
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 24004
- Product name
- Methenamine Hippurate
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- M226025
- Product name
- MethenamineHippurate
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0013675
- Product name
- Methenamine(hippurate)
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
Methenamine hippurate Chemical Properties,Usage,Production
Description
Methenamine hippurate is a broad-spectrum urinary antiseptic agent. Under acidic conditions, methenamine hippurate is hydrolyzed to formaldehyde and ammonia, which exerts an antibacterial effect. It is effective against a wide range of bacteria but lacks activity against Proteus and other bacteria that increase urine alkalinity. Formulations containing methenamine hippurate have been used to treat urinary tract infections.
Chemical Properties
White Solid
Originator
Hiprex ,Merrell National,US,1967
Uses
Antibacterial (urinary).
Definition
ChEBI: Methenamine hippurate is a N-acylglycine. It is functionally related to a N-benzoylglycine.
Manufacturing Process
179 g (1 mol) hippuric acid (benzoyl glycine) and 140 g (1 mol) hexamethylenetetramine were heated under reflux in 500 ml methanol. The small amount of water necessary to give a clear, homogeneous solution was added to the resulting reaction mixture which was then evaporated to dryness. The residue soon crystallized, a procedure that could be greatly accelerated by seeding with crystals of hexamethylenetetramine hippurate from a previous preparation. The resulting solid product was broken up and pulverized. Hexamethylenetetramine hippurate is stable on exposure to air and is soluble in water and alcohol. It melts at 105° to 110°C.
brand name
Urex(Vatring).
Therapeutic Function
Antibacterial (urinary)
General Description
Methenamine hippurate (Hiprex) is the hippuric acid salt ofmethenamine. It is readily absorbed after oral administrationand is concentrated in the urinary bladder, where it exerts itsantibacterial activity. Its activity is increased in acid urine.
Clinical Use
Antibacterial agent
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: increased risk of crystalluria with
sulphonamides.
Diuretics: effects antagonised by acetazolamide.
Metabolism
Under acid conditions methenamine is slowly hydrolysed to formaldehyde and ammonia. Almost no hydrolysis of methenamine takes place at physiological pH, and it is therefore virtually inactive in the body. Methenamine is rapidly and almost completely eliminated in the urine, and provided this is acidic (preferably below pH 5.5) bactericidal concentrations of formaldehyde occur. Because of the time taken for hydrolysis, however, these do not occur until the urine reaches the bladder.
Methenamine hippurate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methenamine hippurate manufacturers
- Product
- Methenamine hippurate 5714-73-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-22
- Product
- Methenamine hippurate 5714-73-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 600 Tons
- Release date
- 2020-05-03