Chloroprocaine hydrochloride
- Product Name
- Chloroprocaine hydrochloride
- CAS No.
- 3858-89-7
- Chemical Name
- Chloroprocaine hydrochloride
- Synonyms
- nesecaine-ce;nesacainehydrochloride;CHLOROPROCAINEHYDROCHLRIDE;Choroprocaine hydrochloride;Tetracaine Solution, 100ppm;chloroprocaine hydrochloride;2-chloroprocainehydrochloride;CHLOROPROCAINE HYDROCHLORIDE (200 MG);Chloroprocaine hydrochloride USP/EP/BP;Chloroprocaine Hydrochloride (1117008)
- CBNumber
- CB2501642
- Molecular Formula
- C13H20Cl2N2O2
- Formula Weight
- 307.2161
- MOL File
- 3858-89-7.mol
Chloroprocaine hydrochloride Property
- Melting point:
- 176-178° (microstage)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/C13H19ClN2O2.ClH/c1-3-16(4-2)9-10-18-13(17)11-5-7-12(15-14)8-6-11;/h5-8,15H,3-4,9-10H2,1-2H3;1H
- InChIKey
- KSEXTRRPURJCDW-UHFFFAOYSA-N
- SMILES
- N(Cl)C1=CC=C(C(=O)OCCN(CC)CC)C=C1.[H]Cl
Safety
- HS Code
- 2922492050
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1117008
- Product name
- Chloroprocaine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $174.4
- Updated
- 2024/03/01
- Product number
- C380265
- Product name
- Chloroprocaine hydrochloride
- Packaging
- 10mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- FC152242
- Product name
- Chloroprocaine HCl
- Packaging
- 25mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FC152242
- Product name
- Chloroprocaine HCl
- Packaging
- 50mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FC152242
- Product name
- Chloroprocaine HCl
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
Chloroprocaine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
crystalline solid
Originator
Nesacaine,Astra,US,1956
Uses
Chloroprocaine Hydrochloride is a local anaesthetic compound showing similar effects to Lidocaine.
Uses
Anesthetic (local).
Definition
ChEBI: The monohydrochloride salt of chloroprocaine. Used as a local anaesthetic, particularly for oral surgery, it has the advantage over lidocaine of constricting blood vessels, so reducing bleeding.
Manufacturing Process
In the first step, 2-chloro-4-aminobenzoyl chloride hydrochloride is prepared
by refluxing a mixture of 25 cc of purified thionyl chloride and 10 g of 2-
chloro-4-aminobenzoic acid until all of the solid has gone into solution. To the
cooled solution is added 150 cc of dry ethyl ether. A brisk stream of dry
hydrogen chloride is passed into the solution until the precipitation of 2-
chloro-4-aminobenzoylchloride hydrochloride is complete. The acyl halide is
removed by filtration and dried in a vacuum desiccator.
In the second step, the diethylaminoethyl 2-chloro-4-aminobenzoate
hydrochloride is prepared by refluxing equimolar proportions of the
hydrochloride of beta-diethylaminoethanol in a suitable inert solvent such as a
mixture of dry toluene and tetrachloroethane and the hydrochloride of 2-
chloro-4-aminobenzoyl chloride until the reaction as indicated by the cessation
of hydrogen chloride evolution is complete. The supernatant solvents are
decanted from the reaction product which can be conveniently purified by
crystallization from absolute ethanol.
An alternative purification can be effected by dissolving the reaction product in
water. The ester base is liberated by rendering the clarified aqueous solution
alkaline. Removal of the base from the alkaline solution is achieved by
extraction with a suitable solvent such as benzene or ether. The pure
hydrochloride of diethylaminoethyl 2-chloro-4-aminobenzoate is then
precipitated from the dried extract by the addition of dry hydrogen chloride.
After removal by filtration and recrystallization from ethanol it is found to
have a melting point of 173° to 174°C.
brand name
Nesacaine (Abraxis).
Therapeutic Function
Local anesthetic
Chloroprocaine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Chloroprocaine hydrochloride manufacturers
- Product
- Chloroprocaine Hydrochloride 3858-89-7
- Price
- US $88.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 330T
- Release date
- 2023-07-21
- Product
- Chloroprocaine hydrochloride 3858-89-7
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-06-25
- Product
- Chloroprocaine hydrochloride 3858-89-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-08