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CYLINDROSPERMOPSIN

Product Name
CYLINDROSPERMOPSIN
CAS No.
143545-90-8
Chemical Name
CYLINDROSPERMOPSIN
Synonyms
cylindrospermopsin;PubChem ID: 42628600;5a-alpha,7-beta(r*))-(-)-h;sulfooxy)-1h-1,8,8b-triazaacenaphthylen-7-yl)methyl)-,(2a-alpha,3-alpha,4-alp;2,4(1h,3h)-pyrimidinedione,6-(hydroxy(2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(;6-[(R)-Hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-2,4(1H,3H)-pyrimidinedione;2,4(1H,3H)-Pyrimidinedione, 6-[(R)-hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-
CBNumber
CB2503323
Molecular Formula
C15H21N5O7S
Formula Weight
415.42
MOL File
143545-90-8.mol
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CYLINDROSPERMOPSIN Property

Density 
1.3937 (rough estimate)
refractive index 
1.6460 (estimate)
storage temp. 
−20°C
solubility 
DMSO: soluble
form 
white powder
pka
-3.78±0.18(Predicted)
EPA Substance Registry System
Cylindrospermopsin (143545-90-8)
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Safety

WGK Germany 
3
RTECS 
UV9104310
Hazardous Substances Data
143545-90-8(Hazardous Substances Data)
Toxicity
mouse,LD50,intraperitoneal,2100ug/kg (2.1mg/kg),LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"BLOOD: CHANGES IN SPLEENKIDNEY, URETER, AND BLADDER: OTHER CHANGES,Toxicologist. Vol. 14, Pg. 211, 1994.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H341Suspected of causing genetic defects

H370Causes damage to organs

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10007867
Product name
Cylindrospermopsin
Purity
≥95%
Packaging
50μg
Price
$289
Updated
2024/03/01
Cayman Chemical
Product number
10007867
Product name
Cylindrospermopsin
Purity
≥95%
Packaging
25μg
Price
$154
Updated
2023/06/20
Cayman Chemical
Product number
10007867
Product name
Cylindrospermopsin
Purity
≥95%
Packaging
100μg
Price
$405
Updated
2024/03/01
Cayman Chemical
Product number
10007867
Product name
Cylindrospermopsin
Purity
≥95%
Packaging
500μg
Price
$1937
Updated
2021/12/16
TRC
Product number
C991455
Product name
Cylindrospermopsin
Packaging
5mg
Price
$24750
Updated
2021/12/16
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CYLINDROSPERMOPSIN Chemical Properties,Usage,Production

Description

Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 μM, respectively), leading to cell death. It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 μM. Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 μg/ml.

Uses

Cylindrospermopsin is a cyanotoxin produced by cyanobacterial species and found in many bodies of water.

Definition

ChEBI: A triazaacenaphthylene that is 2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylene which is substituted at positions 3, 4, and 7 by methyl, sulfooxy, and (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)(hydroxy)methyl groups, respecti ely (the 2aS,3R,4S,5aS,7R stereoisomer in which the carbon bearing the hydroxy group has R configuration). It is a cyanotoxin produced by several species f freshwater cyanobacteria, such as Aphanizomenon ovalisporum.

CYLINDROSPERMOPSIN Preparation Products And Raw materials

Raw materials

Preparation Products

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CYLINDROSPERMOPSIN Suppliers

China 26 France 1 India 1 Switzerland 2 United States 4 USA 1 Global 35
Shanghai EFE Biological Technology Co., Ltd.
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Energy Chemical
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Tianmen Hengchang Chemical Co., Ltd
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0519-88910898 18661161657
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0571-0571-89903882 15990081639
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sunshixuan@huidabiotech.com
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TargetMol Chemicals Inc.
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Naturewill Biotechnology Co., Ltd.
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Shanghai Weiwei Biological Technology Co., Ltd.
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Beijing Jiehui Bogao Biotechnology Co., Ltd.
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143545-90-8, CYLINDROSPERMOPSINRelated Search:

Dictyophora indusiata SongoraMine tremella polysaccharide 3-(alpha,alpha-dimethylallyl)psoralen songorine oleandomycin Hyodeoxycholic acid cinnabarinic acid MICROCYSTIN-LR N,N-DI-ISO-PROPYL-GUANIDINE PIPERIDINE-1-CARBOXAMIDINE CYLINDROSPERMOPSIN 4-(HYDROXY)PIPERIDINE-1-CARBOXAMIDINE

  • PubChem ID: 42628600
  • 6-[(R)-Hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-2,4(1H,3H)-pyrimidinedione
  • 2,4(1h,3h)-pyrimidinedione,6-(hydroxy(2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(
  • 5a-alpha,7-beta(r*))-(-)-h
  • cylindrospermopsin
  • sulfooxy)-1h-1,8,8b-triazaacenaphthylen-7-yl)methyl)-,(2a-alpha,3-alpha,4-alp
  • 2,4(1H,3H)-Pyrimidinedione, 6-[(R)-hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-
  • 143545-90-8
  • 14345-90-8
  • C15H21N5O7S1