CYLINDROSPERMOPSIN Property

Density 

1.3937 (rough estimate)

refractive index 

1.6460 (estimate)

storage temp. 

−20°C

solubility 

DMSO: soluble

form 

white powder

pka

-3.78±0.18(Predicted)

EPA Substance Registry System

Cylindrospermopsin (143545-90-8)

Safety

WGK Germany 

3

RTECS 

UV9104310

Hazardous Substances Data

143545-90-8(Hazardous Substances Data)

Toxicity

mouse,LD50,intraperitoneal,2100ug/kg (2.1mg/kg),LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"BLOOD: CHANGES IN SPLEENKIDNEY, URETER, AND BLADDER: OTHER CHANGES,Toxicologist. Vol. 14, Pg. 211, 1994.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H341Suspected of causing genetic defects

H370Causes damage to organs

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

CYLINDROSPERMOPSIN Chemical Properties,Usage,Production

Description

Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC₅₀s = 1.3 and 2.4 μM, respectively), leading to cell death. It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a K_i value of 10 μM. Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 μg/ml.

Uses

Cylindrospermopsin is a cyanotoxin produced by cyanobacterial species and found in many bodies of water.

Definition

ChEBI: A triazaacenaphthylene that is 2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylene which is substituted at positions 3, 4, and 7 by methyl, sulfooxy, and (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)(hydroxy)methyl groups, respecti ely (the 2aS,3R,4S,5aS,7R stereoisomer in which the carbon bearing the hydroxy group has R configuration). It is a cyanotoxin produced by several species f freshwater cyanobacteria, such as Aphanizomenon ovalisporum.