FTI 277 HYDROCHLORIDE

ChemicalBook > CAS DataBase List > FTI 277 HYDROCHLORIDE

FTI 277 HYDROCHLORIDE

Product Name: FTI 277 HYDROCHLORIDE
CAS No.: 180977-34-8
Chemical Name: FTI 277 HYDROCHLORIDE
Synonyms: CS-1757;FTI 277 HCl;FTI 277 HCL;FTI 277;FTI 277 HYDROCHLORIDE;FTI-277 TRIFLUOROACETATE SALT;FTI 277 HYDROCHLORIDE USP/EP/BP;4-[2(R)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(S)-methionine methyl ester hydrochloride;(S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate FTI 277 HCl;(S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate hydrochloride;(S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate hydrochloride
CBNumber: CB2503510
Molecular Formula: C22H30ClN3O3S2
Formula Weight: 484.075
MOL File: 180977-34-8.mol

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FTI 277 HYDROCHLORIDE Property

storage temp.: Inert atmosphere,2-8°C
solubility: H₂O: soluble
form: amorphous semi-solid
color: White to off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B5842
Product name: FTI277HCl
Packaging: 2mg
Price: $126
Updated: 2021/12/16

ChemScene

Product number: CS-3863
Product name: FTI-277(hydrochloride)
Purity: >99.0%
Packaging: 5mg
Price: $132
Updated: 2021/12/16

ApexBio Technology

Product number: B5842
Product name: FTI277HCl
Packaging: 5mg
Price: $186
Updated: 2021/12/16

ChemScene

Product number: CS-3863
Product name: FTI-277(hydrochloride)
Purity: >99.0%
Packaging: 10mg
Price: $238
Updated: 2021/12/16

ApexBio Technology

Product number: B5842
Product name: FTI277HCl
Packaging: 10mg
Price: $312
Updated: 2021/12/16

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FTI 277 HYDROCHLORIDE Chemical Properties,Usage,Production

Biological Activity

fti-277 is a highly potent and selective ftase inhibitor. at concentration as low as 10 nm, fti-277 inhibits h-ras processing and the processing is blocked by more than 95% at 3 μm. [1]ras proteins are plasma membrane-associated gtpases. it acts as relay switches transducing biological information from extracellular signals to the nucleus. farnesyltransferase (ftase) is an enzyme that catalyzed the ras farnesylation, a lipid posttranslational modification that is required for ras-induced malignant transformation. [1]fti-277, the methyl ester derivative of fti-276, is extremely potent (icgraphic = 100 nm) at inhibiting h-ras, but not the geranylgeranylated rap1a processing in whole cells. fti-277 is a farnesylation-specific inhibitor which inhibits the processing of both oncogenic and normal ras. [1]in mice that hydrodynamically transfected to produce hepatitis delta virus (hdv) viremia, fti-277 treatment is effective in inhibiting viremia. [2]

in vitro

FTI-277 inhibits Ras processing with an IC50 of 100 nM, but not the geranylgeranylated Rap1A processing in whole cells. It induces accumulation of cytoplasmic non-farnesylated H-Ras, accumulates inactive Ras/Raf complexes in the cytoplasm, and constitutive blocksive MAPK activation in H-RasF cells. It causes increased after irradiation and increases radiosensitivity in H-ras-transformed rat embryo cells. FTI-277 also inhibits cell growth and induces apoptosis in drug-resistant myeloma tumor cells. In SH- apoptosis SY5Y cells, It diminishes the toxic effects of methamphetamine on induction in cell degeneration, activation in c-Jun-N-terminal kinase cascades, and Ras activation.

in vivo

In mice coinfected with hepatitis B virus (HBV) and HDV, FTI-277 (50 mg/kg/d ip) effectively clears HDV viremia.

References

1. bordier bb, ohkanda j, liu p et al. in vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. j clin invest. 2003 aug;112(3):407-14.2. lerner ec, qian y, blaskovich ma et al. ras caax peptidomimetic fti-277 selectively blocksoncogenic ras signaling by inducing cytoplasmic accumulation of inactive ras-raf complexes. j biol chem. 1995 nov 10;270(45):26802-6. pubmed pmid: 7592920.

FTI 277 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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FTI 277 HYDROCHLORIDE Suppliers

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180977-34-8, FTI 277 HYDROCHLORIDERelated Search:

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Zoledronic acid 3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

CS-1757

4-[2(R)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(S)-methionine methyl ester hydrochloride

FTI 277 HYDROCHLORIDE

FTI-277 TRIFLUOROACETATE SALT

FTI 277 HCl

(S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate FTI 277 HCl

FTI 277 HCL;FTI 277

FTI 277 HYDROCHLORIDE USP/EP/BP

(S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate hydrochloride

180977-34-8

C22H30ClN3O3S2

Inhibitors