ChemicalBook > CAS DataBase List > IC 261

IC 261

Product Name: IC 261
CAS No.: 186611-52-9
Chemical Name: IC 261
Synonyms: CS-1551;IC261, >98%;IC261 (IC-261;SU-5607 IC 261;IC-261(SU-5607);IC261, 10 mM in DMSO;IC261;SU5607;IC 261;SU 5607;IC261 - CAS 186611-52-9 - Calbiochem;IC 261, CK1delta and CK1epsilon inhibitor;3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one
CBNumber: CB2503626
Molecular Formula: C18H17NO4
Formula Weight: 311.335
MOL File: 186611-52-9.mol

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IC 261 Property

Melting point:: 214 °C
storage temp.: protect from light
solubility: DMSO: 18 mg/mL soluble
form: solid
color: yellow

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Safety

WGK Germany: 3
HS Code: 2933.79.8500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I0658
Product name: IC 261
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $89.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 400090
Product name: IC261
Packaging: 5mg
Price: $216
Updated: 2024/03/01

TCI Chemical

Product number: I1077
Product name: IC 261
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $119
Updated: 2025/07/31

TCI Chemical

Product number: I1077
Product name: IC 261
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $414
Updated: 2025/07/31

Cayman Chemical

Product number: 17260
Product name: IC 261
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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IC 261 Chemical Properties,Usage,Production

General Description

A cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC₅₀ = 0.7-1.3 μM) and CK1ε (IC₅₀ = 0.6-1.4 μM) isozymes. Also inhibits CK1α₁ at much higher concentrations (IC₅₀ = 11-21 μM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34^cdc2 and p55^fyn (IC₅₀s >100 μM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53′s effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.

Biological Activity

ic261 is a novel inhibitor of ck1.the p53-targeted kinases casein kinase 1delta (ck1delta) and casein kinase 1epsilon (ck1epsilon) have been reported to be involved in regulating dna repair and chromosomal segregation.

Biochem/physiol Actions

Cell permeable: yes

in vitro

previoius study found that ic261 could trigger the mitotic checkpoint control. at low micromolar concentrations, ic261 inhibited cytokinesis leading to a transient mitotic arrest. cells with active p53 arrested in the postmitotic g1 phase by blockage of entry into the s phase. cells containing non-functional p53 had postmitotic replication developing an 8n dna content. the increase of dna content was accompanied by a high amount of micronucleated and apoptotic cells. immunfluorescence images also showed that ic261 could result in centrosome amplification causing multipolar mitosis at low concentrations [1].

in vivo

animal study indicated that intrathecal injection of ic261 (0.1-1 nmol) could dose-dependently decrease mechanical allodynia and thermal hyperalgesia that were induced by carrageenan or cfa. in addition, bath-application of ic261 (1 μm) showed only marginal effects on spontaneous excitatory postsynaptic currents recorded in the substantia gelatinosa neurons of control mice. however, ic261 could decrease the frequency of sepscs in both inflammatory pain models [2].

IC 50

16 μm

storage

Store at -20°C

References

1]. behrend l, et al. ic261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. oncogene. 2000 nov 9;19(47):5303-5313.
[2] kurihara t,et al. alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (ck1) inhibitors. mol pain.2014 mar 10;10:17.

IC 261 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from IC 261 manufacturers

Career Henan Chemical Co

Product: IC 261 186611-52-9
Price: US $1.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

186611-52-9, IC 261Related Search:

su5204 SU5208 SU 5214 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE VEGFR2 Kinase Inhibitor I SU 5205 NSC 247030

IC261, >98%

IC-261(SU-5607)

IC261 - CAS 186611-52-9 - Calbiochem

IC261;SU5607;IC 261;SU 5607

CS-1551

SU5607, 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one

1,3-Dihydro-3-[(2,4,6-triMethoxyphenyl)Methylene]-2H-indol-2-one, SU5607

SU-5607 IC 261

(E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one

3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one

IC261,Inhibitor,Apoptosis,IC-261,inhibit,IC 261,Casein Kinase

IC 261, CK1delta and CK1epsilon inhibitor

IC261, 10 mM in DMSO

IC261 (IC-261

186611-52-9

Inhibitors