5-HYDROXY-2-IODOBENZOIC ACID
- Product Name
- 5-HYDROXY-2-IODOBENZOIC ACID
- CAS No.
- 57772-57-3
- Chemical Name
- 5-HYDROXY-2-IODOBENZOIC ACID
- Synonyms
- Benzoic acid, 5-hydroxy-2-iodo-;2-Iodo-5-hydroxybenzoic acid≥ 98% (NMR)
- CBNumber
- CB2506889
- Molecular Formula
- C7H5IO3
- Formula Weight
- 264.02
- MOL File
- 57772-57-3.mol
5-HYDROXY-2-IODOBENZOIC ACID Property
- Melting point:
- 198°C
- Boiling point:
- 394.3±37.0 °C(Predicted)
- Density
- 1.9394 (estimate)
- storage temp.
- 2-8°C(protect from light)
- pka
- 2.74±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H518075
- Product name
- 5-Hydroxy-2-iodobenzoicAcid
- Packaging
- 200mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- HCH0296714
- Product name
- 2-IODO-5-HYDROXYBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $550
- Updated
- 2021/12/16
- Product number
- X8082
- Product name
- 5-Hydroxy-2-iodobenzoicacid
- Packaging
- 5g
- Price
- $657
- Updated
- 2021/12/16
- Product number
- HCH0296714
- Product name
- 2-IODO-5-HYDROXYBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $998.5
- Updated
- 2021/12/16
- Product number
- 57772573
- Product name
- 5-Hydroxy-2-iodobenzoicacid
- Packaging
- 25g
- Price
- $1776.56
- Updated
- 2021/12/16
5-HYDROXY-2-IODOBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
Off-white to tan powder
Synthesis
394-31-0
57772-57-3
General procedure for the synthesis of 5-hydroxy-2-iodobenzoic acid from 2-amino-5-hydroxybenzoic acid: 2-amino-5-hydroxybenzoic acid (1.99 g, 1.33 mmol) was dissolved in water (20 mL), then concentrated hydrochloric acid (10 mL) and sodium nitrite (NaNO2, 1.08 g, 45.6 mmol) were added slowly. The reaction mixture was stirred at 0 °C for 30 min for the diazotization reaction. Subsequently, potassium iodide (KI, 3.24 g, 19.5 mmol) and water (5 mL) were added to the reaction system. The resulting mixture was stirred at 90 °C for 30 min for iodination reaction. After completion of the reaction, the mixture was extracted with ethyl acetate, and the organic layer was washed sequentially with water, dried over anhydrous magnesium sulfate (MgSO4), and then concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 5-hydroxy-2-iodobenzoic acid (2.15 g, 88% yield) as a brown solid with a melting point of 180°C. The product was purified by IR (KBr). The product was analyzed by IR (KBr) showing characteristic absorption peaks: νmax= 3293, 1700, 1666, 1583, 1477, 1427, 1307, 1265, 1241, 1222, 1018, 933, 877, 827, 782 cm-1. 1H NMR (500 MHz, DMSO-d6) data: δ= 6.69 (1H, d, J = 8.5 Hz), 7.13 (1H, s), 7.71 (1H, d, J = 8.5 Hz), 9.9 (1H, s).13C NMR (DMSO-d6) data: δ= 80.5, 117.8, 120.6, 137.9, 141.7, 157.8, 168.3.High-resolution mass spectrometry (HRMS. APCI) analysis: the calculated value of [M + H]+ for C7H5O3I was 264.9361 and the measured value was 264.9377.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 5, p. 1428 - 1433
[2] Angewandte Chemie - International Edition, 2001, vol. 40, # 23, p. 4393 - 4394
[3] Tetrahedron, 2016, vol. 72, # 47, p. 7633 - 7637
[4] Chemistry - An Asian Journal, 2016, vol. 11, # 22, p. 3267 - 3274
[5] Chemistry--A European Journal, 2014, vol. 20, # 36, p. 11336 - 11339,4
5-HYDROXY-2-IODOBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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