5-HYDROXY-2-IODOBENZOIC ACID

5-HYDROXY-2-IODOBENZOIC ACID Property

Melting point:

198°C

Boiling point:

394.3±37.0 °C(Predicted)

Density 

1.9394 (estimate)

storage temp. 

2-8°C(protect from light)

pka

2.74±0.10(Predicted)

Appearance

Light brown to brown Solid

Safety

HS Code 

2916310090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5-HYDROXY-2-IODOBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

Off-white to tan powder

Synthesis

General procedure for the synthesis of 5-hydroxy-2-iodobenzoic acid from 2-amino-5-hydroxybenzoic acid: 2-amino-5-hydroxybenzoic acid (1.99 g, 1.33 mmol) was dissolved in water (20 mL), then concentrated hydrochloric acid (10 mL) and sodium nitrite (NaNO2, 1.08 g, 45.6 mmol) were added slowly. The reaction mixture was stirred at 0 °C for 30 min for the diazotization reaction. Subsequently, potassium iodide (KI, 3.24 g, 19.5 mmol) and water (5 mL) were added to the reaction system. The resulting mixture was stirred at 90 °C for 30 min for iodination reaction. After completion of the reaction, the mixture was extracted with ethyl acetate, and the organic layer was washed sequentially with water, dried over anhydrous magnesium sulfate (MgSO4), and then concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 5-hydroxy-2-iodobenzoic acid (2.15 g, 88% yield) as a brown solid with a melting point of 180°C. The product was purified by IR (KBr). The product was analyzed by IR (KBr) showing characteristic absorption peaks: νmax= 3293, 1700, 1666, 1583, 1477, 1427, 1307, 1265, 1241, 1222, 1018, 933, 877, 827, 782 cm-1. 1H NMR (500 MHz, DMSO-d6) data: δ= 6.69 (1H, d, J = 8.5 Hz), 7.13 (1H, s), 7.71 (1H, d, J = 8.5 Hz), 9.9 (1H, s).13C NMR (DMSO-d6) data: δ= 80.5, 117.8, 120.6, 137.9, 141.7, 157.8, 168.3.High-resolution mass spectrometry (HRMS. APCI) analysis: the calculated value of [M + H]+ for C7H5O3I was 264.9361 and the measured value was 264.9377.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 5, p. 1428 - 1433
[2] Angewandte Chemie - International Edition, 2001, vol. 40, # 23, p. 4393 - 4394
[3] Tetrahedron, 2016, vol. 72, # 47, p. 7633 - 7637
[4] Chemistry - An Asian Journal, 2016, vol. 11, # 22, p. 3267 - 3274
[5] Chemistry--A European Journal, 2014, vol. 20, # 36, p. 11336 - 11339,4