ETHYL CAFFEATE
- Product Name
- ETHYL CAFFEATE
- CAS No.
- 102-37-4
- Chemical Name
- ETHYL CAFFEATE
- Synonyms
- Caffeic acid ethyl ester;Ethyl caffeate;Ethyl caffeoate;Caffeoyl acetate;ETHYL CAFFEATE b;CaffeoylEthylEster;4-dihydroxyphenyl)acrylate;Caffeic acidETHYL CAFFEATE;CAFFEIC ACID ETHYLESTER(RG);Ethyl Caffeate CAS 102-37-4
- CBNumber
- CB2512389
- Molecular Formula
- C11H12O4
- Formula Weight
- 208.21
- MOL File
- 102-37-4.mol
ETHYL CAFFEATE Property
- Melting point:
- 149.5 °C
- Boiling point:
- 377.0±32.0 °C(Predicted)
- Density
- 1.271±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: 250 mg/mL (1200.71 mM)
- form
- Solid
- pka
- 8.71±0.18(Predicted)
- color
- Light yellow to yellow
- LogP
- 2.560
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- E937468
- Product name
- Ethylcaffeoate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 300248
- Product name
- Ethyl caffeate
- Packaging
- 20mg
- Price
- $255
- Updated
- 2021/12/16
- Product number
- orb259223
- Product name
- Ethyl caffeate
- Purity
- 98%
- Packaging
- 100mg
- Price
- $153
- Updated
- 2021/12/16
- Product number
- CS-W019100
- Product name
- EthylCaffeate
- Purity
- 98.91%
- Packaging
- 25g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- orb259223
- Product name
- Ethyl caffeate
- Purity
- 98%
- Packaging
- 1000mg
- Price
- $187
- Updated
- 2021/12/16
ETHYL CAFFEATE Chemical Properties,Usage,Production
Description
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. It suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin.
Chemical Properties
Yellow to tan crystals; characteristic aromatic odor. Insoluble in water; very soluble in alcohol.
Uses
Food antioxidant.
Definition
ChEBI: Ethyl trans-caffeate is an ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol. It has a role as an anti-inflammatory agent and an antineoplastic agent. It is an alkyl caffeate ester and an ethyl ester. It is functionally related to a trans-caffeic acid.
Synthesis
64-17-5
331-39-5
66648-50-8
Caffeic acid (0.5 g, 2.77 mmol) was dissolved in dry ethanol (20 mL) followed by the addition of concentrated sulfuric acid (0.5 mL, 96%, v/v). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (100 mL) and washed with 5% aqueous sodium bicarbonate to neutral pH. the organic layer was subsequently washed with distilled water and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (40% ethyl acetate-hexane as eluent) to afford the target product ethyl 3,4-dihydroxycinnamate (382 mg, 81%) as a white solid. The product characterization data were as follows: melting point 128-140 °C; 1H NMR (400 MHz, DMSO-d6, 25 °C) δ (ppm): 9.58 (br s, 1H, OH), 9.14 (br s, 1H, OH), 7.47 (d, J = 15.93 Hz, 1H, CH=CH), 7.05 (s, 1H, ArH), 7.00 (dd, J = 8.24, 1.16 Hz, 1H, ArH), 6.76 (d, J = 8.12 Hz, 1H, ArH), 6.26 (d, J = 15.89 Hz, 1H, CH=CO), 4.16 (q, J = 7.04 Hz, 2H, CH2CH3), 1.24 (t, J = 7.08 Hz, 3H, CH2CH3) ; 13C NMR (101 MHz, DMSO-d6, 25 °C) δ (ppm): 167.01, 148.83, 146.02, 145.45, 125.97, 121.80, 116.19, 115.26, 114.51, 60.15, 14.73; HRMS m/z calculated for C10H12O4 (H+): 209.0808; found: 209.0811.
IC 50
iNOS; NF-κB; COX-2
References
[1] Journal of Pharmacy and Pharmacology, 2018, vol. 70, # 10, p. 1349 - 1356
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 22, p. 7182 - 7193
[3] Molecules, 2010, vol. 15, # 9, p. 6152 - 6167
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 19, p. 6085 - 6088
[5] Journal of Agricultural and Food Chemistry, 2008, vol. 56, # 4, p. 1376 - 1386
ETHYL CAFFEATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL CAFFEATE Suppliers
- Tel
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- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
- 30
- Tel
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- sales@ajchem.in
- Country
- India
- ProdList
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View Lastest Price from ETHYL CAFFEATE manufacturers
- Product
- Ethyl caffeate 102-37-4
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-04-26
- Product
- ETHYL CAFFEATE 102-37-4
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-10