Phenethyl caffeate

Product Name: Phenethyl caffeate
CAS No.: 104594-70-9
Chemical Name: Phenethyl caffeate
Synonyms: CAFFEIC ACID PHENETHYL ESTER;CAFFEIC ACID PHENYLETHYL ESTER;PHENETHYL CAFFEATE;Phenylethy caffeate;PHENYLETHYL CAFFEATE;PhenethylCaffeate>Caffeic acid pheneth;2-Phenyethyl caffeate;CAPE,PhenethylCaffeate;Caffeic acid phenethyl
CBNumber: CB2438898
Molecular Formula: C17H16O4
Formula Weight: 284.31
MOL File: 104594-70-9.mol

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Phenethyl caffeate Property

Melting point:: 127-129℃
Boiling point:: 498.6±45.0 °C(Predicted)
Density: 1.266±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.
form: White to off-white solid
pka: 8.46±0.20(Predicted)
color: off-white
λmax: 323nm(lit.)
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey: SWUARLUWKZWEBQ-VQHVLOKHSA-N
LogP: 3.734 (est)
CAS DataBase Reference: 104594-70-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-38-37-36
Safety Statements: 26-36
WGK Germany: 3
RTECS: UD3334375
HS Code: 29182900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C8221
Product name: Caffeic acid phenethyl ester
Purity: ≥97% (HPLC), powder
Packaging: 1g
Price: $637
Updated: 2024/03/01

Sigma-Aldrich

Product number: 211200
Product name: CAPE
Purity: A cell-permeable active component of propolis from honeybee hives.
Packaging: 25mg
Price: $187
Updated: 2024/03/01

TCI Chemical

Product number: P2088
Product name: Phenethyl Caffeate
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $24
Updated: 2024/03/01

TCI Chemical

Product number: P2088
Product name: Phenethyl Caffeate
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $118
Updated: 2024/03/01

Alfa Aesar

Product number: J61386
Product name: Phenylethyl 3,4-dihydroxycinnamate, 99+%
Packaging: 250mg
Price: $120.65
Updated: 2024/03/01

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Phenethyl caffeate Chemical Properties,Usage,Production

Description

Phenylethyl caffeate is one of the allergens of propolis (bee glue); also contained in poplar-bud secretions.

Chemical Properties

Off-White Solid

Uses

Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Uses

antineoplastic, antiinflammatory, immunomodulator, NFkB blocker

Uses

Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.

Definition

ChEBI: Phenethyl caffeate is an alkyl caffeate ester in which 2-phenylethyl is the alkyl component. It has a role as an antineoplastic agent, an anti-inflammatory agent, an immunomodulator, a metabolite, an antioxidant, a neuroprotective agent, an antiviral agent and an antibacterial agent.

Biological Activity

Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF- κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.

Contact allergens

Capee is one of the allergens of propolis (bee glue). It is also contained in poplar bud secretions.

Biochem/physiol Actions

CAPE exhibits several properties such as anticarcinogenic, immunomodulatory activities, antioxidant, antiviral, anti-inflammatory, hypoglycaemic effect, cardioprotective and inhibits gastric secretion. It also has an inhibitory effect on fibroblasts growth factor type 2 (FGF-2), a tumor growth factor in breast cancer.

Anticancer Research

Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017).

storage

Store at -20°C

References

1) Sudine et al. (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 21 329 2) Natarajan et al. (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. USA 93 9090 3) Chiao et al. (1995). Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells; Cancer Res. 55 3576 4) Orban et.al. (2000), Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation; Neuroimmunomodulation, 7 99

Phenethyl caffeate Preparation Products And Raw materials

Raw materials

Preparation Products

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Phenethyl caffeate Suppliers

Brazil 1 Canada 2 China 327 Czech Republic 1 France 1 Germany 4 India 6 Japan 2 Poland 1 South Korea 1 Switzerland 7 United Kingdom 10 United States 45 USA 1 Global 409

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Henan Wei Yuan Biotechnology Co., Ltd.

Tel: 0371-27990887 13703782753
Fax: 0371-27536887
Email: xfx@iwysw.com
Country: China
ProdList: 67
Advantage: 62

Hebei Chenguang Tianrun Pharma Co., Ltd.

Tel: 0310-2816865 15175172220
Email: hbcgtr@126.com
Country: China
ProdList: 12
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9414
Advantage: 66

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View Lastest Price from Phenethyl caffeate manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Phenethyl caffeate; Propolis extract 104594-70-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: ≥98% HPLC
Supply Ability: 1000kg
Release date: 2022-09-20

Baoji Guokang Bio-Technology Co., Ltd.

Product: Phenethyl caffeate 104594-70-9
Price: US $952.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2021-06-22

Hebei Weibang Biotechnology Co., Ltd

Product: Phenethyl caffeate 104594-70-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-25

104594-70-9, Phenethyl caffeateRelated Search:

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104594-70-9

15610-29-2

Gene Regulation and Expression

Gene Regulation

BioChemical

Cell Signaling and Neuroscience

Cell Biology

HIV/AIDS/Related Products

Apoptosis Inducers

Miscellaneous Natural Products

Inhibitors

Tyrosine Kinase Inhibitors

Cytokine signaling

104594-70-9