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Phenethyl isothiocyanate

Product Name
Phenethyl isothiocyanate
CAS No.
2257-09-2
Chemical Name
Phenethyl isothiocyanate
Synonyms
(?)-Equol;AKOS B016323;1-(2-ISOTHIOCY;Phenylaethylsenfoel;7-Dihydroxyisoflavan;phenylethylmustardoil;Phenethyl mustard oil;Phenylethyl mustard oil;PHENETHYL ISOTHIOCYANATE;2-PHENETHYL ISOTHIOCYANATE
CBNumber
CB2736659
Molecular Formula
C9H9NS
Formula Weight
163.24
MOL File
2257-09-2.mol
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Phenethyl isothiocyanate Property

Melting point:
143~145℃
Boiling point:
75 °C0.25 mm Hg
Density 
1.094 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.5888(lit.)
FEMA 
4014 | PHENETHYL ISOTHIOCYANATE
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
form 
Liquid
Specific Gravity
1.09
color 
Clear colorless to yellow
Odor
at 0.01 % in propylene glycol. green horseradish gooseberry watercress
Odor Type
sulfurous
Water Solubility 
insoluble
Sensitive 
Moisture Sensitive
Merck 
14,7226
JECFA Number
1563
BRN 
2084162
InChIKey
IZJDOKYDEWTZSO-UHFFFAOYSA-N
LogP
3.47
CAS DataBase Reference
2257-09-2(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, (2-isothiocyanatoethyl)-(2257-09-2)
EPA Substance Registry System
Benzene, (2-isothiocyanatoethyl)- (2257-09-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-42-42/43
Safety Statements 
23-26-36-36/37
RIDADR 
UN 2206 6.1/PG 3
WGK Germany 
3
RTECS 
NX9115000
10-23
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29309090
Toxicity
LD50 in mice (mg/kg): 700 orally; 150 s.c.; 50 i.v. (Lichtenstein)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W401404
Product name
2-Phenylethyl isothiocyanate
Purity
FG
Packaging
25g
Price
$115
Updated
2024/03/01
Sigma-Aldrich
Product number
W401404
Product name
2-Phenylethyl isothiocyanate
Purity
FG
Packaging
100g
Price
$169
Updated
2024/03/01
Sigma-Aldrich
Product number
W401404
Product name
2-Phenylethyl isothiocyanate
Purity
FG
Packaging
1kg
Price
$1340
Updated
2024/03/01
Sigma-Aldrich
Product number
253731
Product name
Phenethyl isothiocyanate
Purity
99%
Packaging
5g
Price
$58.7
Updated
2024/03/01
Sigma-Aldrich
Product number
68488
Product name
Phenethyl isothiocyanate
Purity
analytical standard
Packaging
250mg
Price
$86.2
Updated
2022/05/15
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Phenethyl isothiocyanate Chemical Properties,Usage,Production

Description

Phenethyl isothiocyanate is a naturally occurring isothiocyanate in cruciferous vegetables. Phenethyl isothiocyanate is a chemopreventive agent. It inhibits cancer cell growth by arresting the cell cycle and inducing apoptosis in various human cancer cell models.

Chemical Properties

Light Yellow Liquid

Chemical Properties

Phenethyl isothiocyanate has a strong green irritating odor.

Uses

Phenethyl isothiocyanate is an NNK-induced lung tumorigenesis inhibitor.

Uses

Flavor ingredient; provides the hot or burning sensation in horseradish.
Phenethyl isothiocyanate (PEITC),one of the major compounds from dietary cruciferousvegetables,has been found to have antitumor properties and therefore could generate special interest for the development of chemopreventive andor chemotherapeutic agent for human cancers.

Preparation

Prepared by hydrolysis of gluconasturtiin, an abundant natural product present in cruciferous vegetables.

Definition

ChEBI: An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties.

General Description

Phenethyl isothiocyanate, an organic isothiocyanate, is a cruciferous vegetable ingredient present as a glucosinolate in cabbage, turnips, radishes, etc. It is a well-known chemopreventive agent reported to be effective against cancers affecting the lung, breast, pancreas, prostate and so on.

Pharmacokinetics

Phenethyl isothiocyanate (PEITC) is one of the most extensively studied members of the isothiocyanate family, found in cruciferous vegetables, such as watercress. It is responsible for anti-cancer activities. In addition, it has shown to inhibit migration and invasion of many types of human cancer cells. PEITC selectively kills cancer cells, but not normal cells. It generates reactive oxygen species (ROS) to trigger signal transduction, leading to cell cycle arrest, autophagy, and/or apoptosis. However, the molecular mechanisms by which PEITC acts as a growth inhibitor and autophagy and/or apoptosis inducer in cancer cells have not been fully investigated. PEITC also is able to activate ERK and JNK signal transduction, which in turn induces expression of stress-responsive genes. Specifically, this agent has been shown to reactivate gene expression of a detoxification enzyme, glutathione S-transferase that is silenced in prostate carcinoma.
Phenethyl Isothiocyanate has been used in trials studying the prevention and treatment of Leukemia, Lung Cancer, Tobacco Use Disorder, and Lymphoproliferative Disorders.

Anticancer Research

PEITC is a naturally occurring isothiocyanate, found mostly in cruciferous vegetablesincluding cauliflower, watercress, cabbage, Brussels sprouts, garden cress, broccoli,and bok choy. It shows chemopreventive and anticancer activity againstmelanoma, breast cancer, myeloma, human liver hepatoma, non-small cell lung cancer,cervical cancer, prostate cancer, and osteogenic sarcoma. It induces apoptosis in some drug resistance cell lines. Its mechanism of action is much diversified in variouscancer cells. It induces apoptosis in highly metastatic human non-small cell lungcancer, L9981 cells via caspase-3 activation, and cell cycle arrest in G2/M phase bymodulation of cyclin B1 expression while targeting MAPK/AP-1 pathway. In cervicalcancer cells, it increases the death receptor (DR4, DR5) expression, cleaves caspase-3, induces caspase-8, truncates BID, and downregulates ERK1/2 and MEKphosphorylation while maintaining the expression of JNK and phospho-p38MAPK. In human prostate cancer (DU 145) cell line, PEITC induces apoptosis byactivating caspase cascade pathway (Wang et al. 2012; Cheung and Kong 2010).

Phenethyl isothiocyanate Preparation Products And Raw materials

Raw materials

Preparation Products

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Phenethyl isothiocyanate Suppliers

Wuhan kemike Biomedical Technology Co., Ltd
Tel
027-13163388153 13163388153
Email
yeqiu416@163.com
Country
China
ProdList
9979
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35906
Advantage
56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11605
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17840
Advantage
64
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View Lastest Price from Phenethyl isothiocyanate manufacturers

Hebei Yibangte Import and Export Co. , Ltd.
Product
Phenethyl isothiocyanate 2257-09-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000kg
Release date
2023-06-02
Hebei Guanlang Biotechnology Co., Ltd.
Product
Phenethyl isothiocyanate 2257-09-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2022-09-29
Career Henan Chemical Co
Product
2-isothiocyanatobenzonitrile 2257-09-2
Price
US $10.00-100.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-03-06

2257-09-2, Phenethyl isothiocyanateRelated Search:


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