Phenethyl isothiocyanate

ChemicalBook > CAS DataBase List > Phenethyl isothiocyanate

Phenethyl isothiocyanate

Product Name: Phenethyl isothiocyanate
CAS No.: 2257-09-2
Chemical Name: Phenethyl isothiocyanate
Synonyms: (?)-Equol;AKOS B016323;1-(2-ISOTHIOCY;Phenylaethylsenfoel;7-Dihydroxyisoflavan;phenylethylmustardoil;Phenethyl mustard oil;Phenylethyl mustard oil;PHENETHYL ISOTHIOCYANATE;2-PHENETHYL ISOTHIOCYANATE
CBNumber: CB2736659
Molecular Formula: C9H9NS
Formula Weight: 163.24
MOL File: 2257-09-2.mol

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Phenethyl isothiocyanate Property

Melting point:: 143～145℃
Boiling point:: 75 °C0.25 mm Hg
Density: 1.094 g/mL at 25 °C(lit.)
refractive index: n20/D 1.5888(lit.)
FEMA: 4014 | PHENETHYL ISOTHIOCYANATE
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
form: Liquid
color: Clear colorless to yellow
Specific Gravity: 1.09
Odor: at 0.01 % in propylene glycol. green horseradish gooseberry watercress
Odor Type: sulfurous
Water Solubility: insoluble
Sensitive: Moisture Sensitive
JECFA Number: 1563
Merck: 14,7226
BRN: 2084162
InChIKey: IZJDOKYDEWTZSO-UHFFFAOYSA-N
LogP: 3.47
CAS DataBase Reference: 2257-09-2(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, (2-isothiocyanatoethyl)-(2257-09-2)
EPA Substance Registry System: Benzene, (2-isothiocyanatoethyl)- (2257-09-2)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38-42-42/43
Safety Statements: 23-26-36-36/37
RIDADR: UN 2206 6.1/PG 3
WGK Germany: 3
RTECS: NX9115000
F: 10-23
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29309090
Toxicity: LD50 in mice (mg/kg): 700 orally; 150 s.c.; 50 i.v. (Lichtenstein)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W401404
Product name: 2-Phenylethyl isothiocyanate
Purity: FG
Packaging: 25g
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: W401404
Product name: 2-Phenylethyl isothiocyanate
Purity: FG
Packaging: 100g
Price: $169
Updated: 2024/03/01

Sigma-Aldrich

Product number: W401404
Product name: 2-Phenylethyl isothiocyanate
Purity: FG
Packaging: 1kg
Price: $1340
Updated: 2024/03/01

Sigma-Aldrich

Product number: 253731
Product name: Phenethyl isothiocyanate
Purity: 99%
Packaging: 5g
Price: $58.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 68488
Product name: Phenethyl isothiocyanate
Purity: analytical standard
Packaging: 250mg
Price: $86.2
Updated: 2022/05/15

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Phenethyl isothiocyanate Chemical Properties,Usage,Production

Description

Phenethyl isothiocyanate is a naturally occurring isothiocyanate in cruciferous vegetables. Phenethyl isothiocyanate is a chemopreventive agent. It inhibits cancer cell growth by arresting the cell cycle and inducing apoptosis in various human cancer cell models.

Chemical Properties

Light Yellow Liquid

Chemical Properties

Phenethyl isothiocyanate has a strong green irritating odor.

Uses

Phenethyl isothiocyanate is an NNK-induced lung tumorigenesis inhibitor.

Uses

Flavor ingredient; provides the hot or burning sensation in horseradish.
Phenethyl isothiocyanate (PEITC)，one of the major compounds from dietary cruciferousvegetables，has been found to have antitumor properties and therefore could generate special interest for the development of chemopreventive andor chemotherapeutic agent for human cancers.

Preparation

Prepared by hydrolysis of gluconasturtiin, an abundant natural product present in cruciferous vegetables.

Definition

ChEBI: An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties.

General Description

Phenethyl isothiocyanate, an organic isothiocyanate, is a cruciferous vegetable ingredient present as a glucosinolate in cabbage, turnips, radishes, etc. It is a well-known chemopreventive agent reported to be effective against cancers affecting the lung, breast, pancreas, prostate and so on.

Pharmacokinetics

Phenethyl isothiocyanate (PEITC) is one of the most extensively studied members of the isothiocyanate family, found in cruciferous vegetables, such as watercress. It is responsible for anti-cancer activities. In addition, it has shown to inhibit migration and invasion of many types of human cancer cells. PEITC selectively kills cancer cells, but not normal cells. It generates reactive oxygen species (ROS) to trigger signal transduction, leading to cell cycle arrest, autophagy, and/or apoptosis. However, the molecular mechanisms by which PEITC acts as a growth inhibitor and autophagy and/or apoptosis inducer in cancer cells have not been fully investigated. PEITC also is able to activate ERK and JNK signal transduction, which in turn induces expression of stress-responsive genes. Specifically, this agent has been shown to reactivate gene expression of a detoxification enzyme, glutathione S-transferase that is silenced in prostate carcinoma.
Phenethyl Isothiocyanate has been used in trials studying the prevention and treatment of Leukemia, Lung Cancer, Tobacco Use Disorder, and Lymphoproliferative Disorders.

Anticancer Research

PEITC is a naturally occurring isothiocyanate, found mostly in cruciferous vegetablesincluding cauliflower, watercress, cabbage, Brussels sprouts, garden cress, broccoli,and bok choy. It shows chemopreventive and anticancer activity againstmelanoma, breast cancer, myeloma, human liver hepatoma, non-small cell lung cancer,cervical cancer, prostate cancer, and osteogenic sarcoma. It induces apoptosis in some drug resistance cell lines. Its mechanism of action is much diversified in variouscancer cells. It induces apoptosis in highly metastatic human non-small cell lungcancer, L9981 cells via caspase-3 activation, and cell cycle arrest in G2/M phase bymodulation of cyclin B1 expression while targeting MAPK/AP-1 pathway. In cervicalcancer cells, it increases the death receptor (DR4, DR5) expression, cleaves caspase-3, induces caspase-8, truncates BID, and downregulates ERK1/2 and MEKphosphorylation while maintaining the expression of JNK and phospho-p38MAPK. In human prostate cancer (DU 145) cell line, PEITC induces apoptosis byactivating caspase cascade pathway (Wang et al. 2012; Cheung and Kong 2010).

Phenethyl isothiocyanate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Phenethyl isothiocyanate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Phenethyl isothiocyanate 2257-09-2
Price: US $55.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-15

Hebei Weibang Biotechnology Co., Ltd

Product: Phenethyl isothiocyanate 2257-09-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-06

JINING XINHE CHEMICAL CO., LTD

Product: Phenethyl isothiocyanate 2257-09-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10ton
Release date: 2024-07-22

2257-09-2, Phenethyl isothiocyanateRelated Search:

Phenyl isothiocyanate Phenoxyethyl isobutyrate ISOCYANIC ACID Dithiooxamide 4-Chlorophenyl isocyanate Fluorescein isothiocyanate BENZYL ISOTHIOCYANATE Allyl isothiocyanate 3,4-DIMETHOXYPHENETHYL ISOTHIOCYANATE 2-(4-CHLOROPHENYL)ETHYL ISOTHIOCYANATE (S)-(+)-1-PHENYLETHYL ISOTHIOCYANATE,(+)-1-PHENYLETHYL ISOTHIOCYANATE (n)-1-phenylethyl isothiocyanate (R)-(-)-1-PHENYLETHYL ISOTHIOCYANATE Ethyl isothiocyanate 2,4-dichloro-1-(2-isothiocyanatoethyl)benzene 4-METHYLPHENETHYL ISOTHIOCYANATE 2,2-DIPHENYLETHYL ISOTHIOCYANATE 2,5-DIMETHOXYPHENETHYL ISOTHIOCYANATE

2-Phenylethyl isothiocyanate, Phenethyl isothiocyanate

β-Phenylethyl isothiocyanate, Phenethyl isothiocyanate

Isothiocyanic acid phenethyl

PHENETHYL GLUCOSINOLATE POTASSIUM SALT(GLUCONASTURTIIN)(RG)

Isothiocyanic Acid 2-Phenylethyl Ester Phenethyl Isothiocyanate

PHENYLETHYL ISOTHIOCYANATE(P)(REQUEST QUOTE)

Phenethyl isothiocyanate 99%

2-Phenylethyl Isothiocyanate, 97.0%(GC)

Phenylethyl isothiocyanate,96%

ISOTHIOCYANIC ACID BETA-PHENYLETHYL ESTER

BETA-PHENETHYL ISOTHIOCYANATE

B-PHENYLETHYL ISOTHIOCYANATE

2-PHENYLETHYL ISOTHIOCYANATE

2-ISOTHIOCYANATOETHYLBENZENE

2-PHENETHYL ISOTHIOCYANATE

1-(2-ISOTHIOCYANATOETHYL)BENZENE

phenylethylmustardoil

2-PHENETHYL ISOTHIOCYANATE 99+%

isothiocyanic acid 2-phenylethyl ester

PHENYLETHYLISOTHIOCYANATES

b-Phenethyl isothiocyate, 99%

(2-isothiocyanatoethyl)-benzen

AKOS B016323

PHENETHYL ISOTHIOCYANATE

PHENYLETHYL ISOTHIOCYANATE

Benzene, (2-isothiocyanatoethyl)-

beta-Phenylethyl isothiocyanate

beta-phenylethylisothiocyanate

Isothiocyanic acid, phenethyl ester

isothiocyanicacid,phenethylester

Phenethyl mustard oil

Phenylaethylsenfoel

Phenylethyl mustard oil

2-PhenylethylIsothiocyanate&gt

2-Phenylethyl Isothiocyanate,>98%

(?)-Equol

7-Dihydroxyisoflavan

1-(2-ISOTHIOCY

2257-09-2

9/2/2257

2257-09-02

2257-9-2

C6H5CH2CH2NCS

C9H9NS

Organic Building Blocks

Chemopreventive Agents

Cancer Research

Sulfur Compounds

Thiocyanates/Isothiocyanates

Anti-proliferative Agents

Building Blocks

BioChemical

Aromatics Compounds

Aromatics

Sulfur & Selenium Compounds