Piperazine-2-carboxylic acid
- Product Name
- Piperazine-2-carboxylic acid
- CAS No.
- 2762-32-5
- Chemical Name
- Piperazine-2-carboxylic acid
- Synonyms
- DS-1093;DS-1043;PRZCA-2HCL;TIMTEC-BB SBB003518;2-Piperazinecarboxyl;piperazine-2-carboxylicaci;PIPERAZINE-2-CARBOXYLIC ACID;(±)-Piperazine-2-carboxylic acid;PIPERAZINE-2-CARBOXYLIC ACID 2HCL;(^+)-Piperazine-2-carboxylic acid
- CBNumber
- CB2663395
- Molecular Formula
- C5H10N2O2
- Formula Weight
- 130.15
- MOL File
- 2762-32-5.mol
Piperazine-2-carboxylic acid Property
- Melting point:
- 265 °C (dec.)(lit.)
- Boiling point:
- 313.6±37.0 °C(Predicted)
- Density
- 1.174
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.90±0.20(Predicted)
- Appearance
- White to yellow Solid
- optical activity
- Consistent with structure
- InChI
- InChI=1S/C5H10N2O2/c8-5(9)4-3-6-1-2-7-4/h4,6-7H,1-3H2,(H,8,9)
- InChIKey
- JSSXHAMIXJGYCS-UHFFFAOYSA-N
- SMILES
- N1CCNCC1C(O)=O
- CAS DataBase Reference
- 2762-32-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- P991853
- Product name
- Piperazine-2-carboxylicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W002409
- Product name
- Piperazine-2-carboxylicacid
- Purity
- >98.0%
- Packaging
- 100g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- 074978
- Product name
- Piperazine-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- J98649
- Product name
- Piperazine-2-carboxylicacid
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- CS-W002409
- Product name
- Piperazine-2-carboxylicacid
- Purity
- >98.0%
- Packaging
- 500g
- Price
- $302
- Updated
- 2021/12/16
Piperazine-2-carboxylic acid Chemical Properties,Usage,Production
Uses
Piperazine-2-carboxylic acid is an important organic compound used as a basic structural component of pharmaceutical intermediates. Studies have shown that Piperazine-2-carboxylic acid derivatives are a potential multi-targeted ligands (MTDLs) anti-Alzheimer's disease (AD) active ingredient.
Synthesis
98-97-5
2762-32-5
Step 1: Preparation of piperazine-2-carboxylic acid: pyrazine-2-carboxylic acid (102.7 g, 0.827 mol) was dissolved in water (600 mL), sodium hydroxide (66 g, 1.65 mol) and 20% palladium/carbon catalyst (5.0 g) were added. The hydrogenation reaction was carried out under hydrogen atmosphere for 15 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. Concentrated hydrochloric acid was added to the concentrate and a white precipitate precipitated. The solid was washed with cold water, collected by filtration and dried under vacuum to give 137.2 g of piperazine-2-carboxylic acid hydrochloride (99.6% yield). Mass spectrum (MS): m/z 131 (corresponding to C5H10N2O2, [M+H]+).
References
[1] Tetrahedron Letters, 1989, vol. 30, # 39, p. 5193 - 5196
[2] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 8, p. 1121 - 1126
[3] Patent: US6251919, 2001, B1
Piperazine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Piperazine-2-carboxylic acid Suppliers
- Tel
- --
- Fax
- --
- nfo@alkemi.be
- Country
- Belgium
- ProdList
- 2201
- Advantage
- 58
View Lastest Price from Piperazine-2-carboxylic acid manufacturers
- Product
- Piperazine-2-carboxylic acid 2762-32-5
- Price
- US $0.00-0.00/drums
- Min. Order
- 1drums
- Purity
- 99%min.
- Supply Ability
- 10tons
- Release date
- 2023-10-22
- Product
- 2-Piperazinecarboxylic acid dihydrochloride 2762-32-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-24
- Product
- 2-Piperazinecarboxylic acid dihydrochloride 2762-32-5
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-25