ChemicalBook > CAS DataBase List > H-D-PHG-OME HCL

H-D-PHG-OME HCL

Product Name
H-D-PHG-OME HCL
CAS No.
19883-41-1
Chemical Name
H-D-PHG-OME HCL
Synonyms
2-phenylglycine methyl ester hydrochloride;D-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE;(R)-Methyl 2-aMino-2-phenylacetate hydrochloride;Methyl (R)-2-Amino-2-Phenylacetate Hydrochloride;methyl (2R)-2-amino-2-phenylacetate hydrochloride;T0400-4069;D-Peg-Oe.H Cl;H-D-PHG-OME HCL;H-D-Phg · OCH3 · HCl;Cephalexin Impurity 1
CBNumber
CB2664271
Molecular Formula
C9H12ClNO2
Formula Weight
201.65
MOL File
19883-41-1.mol
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H-D-PHG-OME HCL Property

Melting point:
189-191 °C(lit.)
alpha 
-118o (C=1 IN H2O)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder to crystal
color 
White to Almost white
optical activity
[α]20/D 118°, c = 1 in H2O
BRN 
3915654
InChI
InChI=1/C9H11NO2.ClH/c1-12-9(11)8(10)7-5-3-2-4-6-7;/h2-6,8H,10H2,1H3;1H/t8-;/s3
InChIKey
DTHMTBUWTGVEFG-DDWIOCJRSA-N
SMILES
C(OC)(=O)[C@H](C1=CC=CC=C1)N.[H]Cl |&1:4,r|
CAS DataBase Reference
19883-41-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26-36/37
WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
307882
Product name
(R)-(?)-2-Phenylglycine methyl ester hydrochloride
Purity
≥95%
Packaging
25g
Price
$53.9
Updated
2023/01/07
Sigma-Aldrich
Product number
307882
Product name
(R)-(?)-2-Phenylglycine methyl ester hydrochloride
Purity
≥95%
Packaging
100g
Price
$149
Updated
2023/01/07
TCI Chemical
Product number
P2592
Product name
D-(-)-2-Phenylglycine Methyl Ester Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$33
Updated
2025/07/31
TRC
Product number
P327235
Product name
(R)-(?)-2-Phenylglycine methyl ester hydrochloride
Packaging
5g
Price
$60
Updated
2021/12/16
AK Scientific
Product number
J98326
Product name
D-(-)-alpha-Phenylglycinemethylesterhydrochloride
Packaging
25g
Price
$14
Updated
2021/12/16
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H-D-PHG-OME HCL Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

(R)-(-)-2-Phenylglycine Methyl Ester Hydrochloride is an intermediate in the synthesis of Cephradine, a cephalosporin antibiotic. It functions as an acyl donor in the enzymatic synthetic process for cephradine synthesis.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

875-74-1

19883-41-1

Methylation reaction of L-phenylglycine. L-phenylglycine (1 g, 6.05 mmol, 1.0 eq.) was suspended in methanol (25 mL) and cooled to 0°C. Thionyl chloride (475 μL, 6.66 mmol, 1.5 eq.) was slowly added. after 10 min, the reaction mixture was heated to 75 °C and refluxed for 2 h. The reaction was completed by TLC. After completion of the reaction (monitored by TLC), the solvent was removed under vacuum to give a white solid, L-phenylglycine methyl ester hydrochloride (1.23 g, quantitative yield).

References

[1] Tetrahedron, 1999, vol. 55, # 11, p. 3337 - 3354
[2] European Journal of Organic Chemistry, 2009, # 30, p. 5185 - 5191
[3] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 649 - 660
[4] Tetrahedron, 2009, vol. 65, # 6, p. 1200 - 1206
[5] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992, # 8, p. 1279 - 1285

H-D-PHG-OME HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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H-D-PHG-OME HCL Suppliers

China 350 Germany 5 India 18 Japan 4 South Korea 1 Switzerland 1 United Kingdom 1 United States 24 Global 404
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View Lastest Price from H-D-PHG-OME HCL manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
(R)-(-)-2-Phenylglycine methyl ester hydrochloride 19883-41-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-07
Hebei Chuanghai Biotechnology Co., Ltd
Product
H-D-PHG-OME HCL 19883-41-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-28
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-D-Phg-OMe·HCl 19883-41-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-04-03

19883-41-1, H-D-PHG-OME HCLRelated Search:

Di-tert-butyl peroxide Glycine ethyl ester hydrochloride Sodium iodide Glycine methyl ester hydrochloride ETHYL (R)-(-)-MANDELATE (R)-4-CHLORO PHENYLGLYCINE H-D-PHG-OTBU HCL D(-)-Phenylglycinamide H-D-Phg-Gly-OH METHYL (2R)-2-AMINO-3-(2-CHLORO(4-PYRIDYL))PROPANOATE METHYL (2R)-2-AMINO-3-(2,6-DICHLORO(3-PYRIDYL))PROPANOATE METHYL (2R)-2-AMINO-3-(2,6-DIFLUOROPYRIDIN-3-YL)PROPANOATE METHYL (2R)-2-AMINO-3-(2,6-DIMETHYL(3-PYRIDYL))PROPANOATE methyl (R)-aminophenylacetate methyl (2R)-2-amino-3-(2-fluorophenyl)propanoate hydrochloride METHYL (2R)-2-AMINO-3-(2-AMINO-4-FLUOROPHENYL)PROPANOATE (Z)-Cefdinir Cefdinir Impurity E

  • Methyl α-aMinophenylacetate HCl
  • (R)-Methyl 2-aMino-2-phenylacetate hydrochloride
  • (2-keto-2-methoxy-1-phenyl-ethyl)ammonium chloride
  • (2-methoxy-2-oxo-1-phenylethyl)ammonium chloride
  • (2-methoxy-2-oxo-1-phenyl-ethyl)ammonium chloride
  • (2-methoxy-2-oxo-1-phenylethyl)azanium chloride
  • (2-methoxy-2-oxo-1-phenyl-ethyl)azanium chloride
  • methyl amino(phenyl)acetate hydrochloride
  • T0400-4069
  • H-D-Phg · OCH3 · HCl
  • (R)-(-)-2-Phenylglycine Methyl ester hydrochloride >=95%
  • methyl 2-azanyl-2-phenyl-ethanoate
  • (R)-(-)-2-Phenylglycine methyl ester hydrochloride -()-2-Phenylglycine methyl ester hydrochloride ,98%
  • D-(-)-2-Phenylglycine Methyl ester hydrochloride, 96%
  • D-Peg-Oe.H Cl
  • Cephalexin Impurity 1
  • D-(-)-ALPHA-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
  • D-ALPHA-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
  • D-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
  • D-PHENYLGLYCINE-OME HCL
  • H-D-PHG-OME HCL
  • (R)-(-)-2-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
  • Cephalexin Impurity 1 (D-Phenylglycine Methyl Ester)
  • (R)-(-)-2-Aminophenylacetic acid methyl ester hydrochloride
  • D-Phenylglycine methyl ester hydrochloride≥ 99% (HPLC)
  • D-Phenylglycine Methyl Ester Hydrochloride,99%e.e.
  • R-Phenyl Glycine methyl ester HCL
  • methyl (R)-aminophenylacetate hydrochloride
  • R-phenylglycine methyl ester hydrochloride
  • D-Phenylglycine Methyl Ester HCl
  • (r)-(-)-à-aminophenylacetic acid methyl ester hydrochloride
  • d-(-)-à-phenylglycine methyl ester hydrochloride
  • D-(-)-A-PHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
  • D-Phenylglycine methyl ester hydrochlorid
  • (R)-(-)-2-phenylglycine methyl ester Hydrochloride ,98%
  • D-Phenylycine methyl ester hydrichloride
  • D-Phenylglycine methyl·hydrochloric acid
  • D-Phenylglycine methyl·hydrochloride
  • 2-phenylglycine methyl ester hydrochloride
  • D-(-)-ɑ-Phenylglycine methyl ester hydrochloride, 96%
  • D-(-)-alpha-Phenylglycine methyl ester hydrochloride, 98+%
  • (R)-(-)-alpha-Aminophenylacetic acid Methyl Ester Hydrochloride
  • D(-)-ALPA-PHENYL GLYCINE METHYL ESTER HYDROCHLORIDE
  • methyl (2R)-2-amino-2-phenylacetate hydrochloride
  • (R)-(-)-2-Phenylglycine methyl ester HCI
  • D-ALPHA-PHENYLGLYCINE METHYLESTER HCL
  • Methyl (R)-2-Amino-2-Phenylacetate Hydrochloride
  • 2-(2-aminophenyl)acetic acid methyl ester
  • H-D-Phg-OMe·HCl H-D-Phenylglycine methyl ester hydrochloride
  • Cephalexin Impurity 1 HCl (D-Phenylglycine Methyl Ester HCl)
  • Benzeneacetic acid, a-amino-, methyl ester, hydrochloride, (aR)-
  • D-ALPHA-Phenylglycine Methylester HCL / H-D-PHG-OME HCL
  • Cephalexin Impurity 1 HCl
  • H-D-Phg-OMe hydrochloride
  • (R)-(-)-2-Amino-2-phenylacetic Acid Methyl Ester Hydrochloride
  • H-D-PHG-OME HCL USP/EP/BP
  • (R)-()-2-Phenylglycine methyl ester hydrochlorideQ: What is (R)-()-2-Phenylglycine methyl ester hydrochloride Q: What is the CAS Number of (R)-()-2-Phenylglycine methyl ester hydrochloride
  • D-(-)-ALPHA-PHENYLGLYCINE METHYL ESTER HYD