4-(3-BROMOPHENYL)MORPHOLINE
- Product Name
- 4-(3-BROMOPHENYL)MORPHOLINE
- CAS No.
- 197846-82-5
- Chemical Name
- 4-(3-BROMOPHENYL)MORPHOLINE
- Synonyms
- 4-(3-bromophenyl)morpholino;4-(3-BROMOPHENYL)MORPHOLINE;N-(3-BroMophenyl)Morpholine;1-(3-bromophenyl)-morpholine;Morpholine,4-(3-broMophenyl)-;4-(3-Bromophenyl)morpholine96%;1-BROMO-3-(4-MORPHOLINO)BENZENE;4-(3-Bromophenyl)morpholine 96%;1-Bromo-3-(morpholin-4-yl)benzene
- CBNumber
- CB2664877
- Molecular Formula
- C10H12BrNO
- Formula Weight
- 242.11
- MOL File
- 197846-82-5.mol
4-(3-BROMOPHENYL)MORPHOLINE Property
- Boiling point:
- 341.1±37.0 °C(Predicted)
- Density
- 1.433
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.02±0.40(Predicted)
- form
- liquid
- color
- Clear, brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS003639
- Product name
- 1-bromo-3-(4-morpholino)benzene
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 250 mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- B700298
- Product name
- 4-(3-Bromophenyl)morpholine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B700298
- Product name
- 4-(3-Bromophenyl)morpholine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H56-9-V8
- Product name
- 4-(3-Bromophenyl)morpholine
- Purity
- 96%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 4H56-9-V8
- Product name
- 4-(3-Bromophenyl)morpholine
- Purity
- 96%
- Packaging
- 25g
- Price
- $392
- Updated
- 2021/12/16
4-(3-BROMOPHENYL)MORPHOLINE Chemical Properties,Usage,Production
Synthesis
110-91-8
108-36-1
197846-82-5
1,3-Dibromobenzene (50 g, 0.21 mol) and morpholine (15.89 mL, 0.19 mol) were used as raw materials, and both were added to the reaction flask with anhydrous toluene (200 mL) via a syringe under argon protection. After thorough mixing, R-BINAP (1.32 g, 0.0021 mol), palladium(0) dibenzylideneacetone (0.640 g, 0.006 mol) and DBU (25.8 mL, 0.17 mol) were added sequentially. The reaction mixture was stirred at 60 °C, followed by the addition of sodium tert-butoxide (30.55 g, 0.32 mol) and the reaction temperature was raised to 100 °C and continued overnight. Upon completion of the reaction, the suspension was diluted with ethyl acetate, filtered through diatomaceous earth and the organic phase was washed sequentially with water and brine. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent ethyl acetate:hexane (1:1) to afford the target compound 4-(3-bromophenyl)morpholine as a yellow oil (36.5 g, 71% yield). Mass spectrometry (ES+) showed the molecular ion peak m/z 242 ([M+H]+).
References
[1] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 28
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5522 - 5537
[3] Tetrahedron, 2008, vol. 64, # 13, p. 2938 - 2950
[4] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 25-26
4-(3-BROMOPHENYL)MORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-(3-BROMOPHENYL)MORPHOLINE Suppliers
- Tel
- --
- Fax
- --
- Country
- Belgium
- ProdList
- 6293
- Advantage
- 73
View Lastest Price from 4-(3-BROMOPHENYL)MORPHOLINE manufacturers
- Product
- 4-(3-BROMOPHENYL)MORPHOLINE 197846-82-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24