ChemicalBook > CAS DataBase List > 4-(3-BROMOPHENYL)MORPHOLINE

4-(3-BROMOPHENYL)MORPHOLINE

Product Name: 4-(3-BROMOPHENYL)MORPHOLINE
CAS No.: 197846-82-5
Chemical Name: 4-(3-BROMOPHENYL)MORPHOLINE
Synonyms: 4-(3-bromophenyl)morpholino;4-(3-BROMOPHENYL)MORPHOLINE;N-(3-BroMophenyl)Morpholine;1-(3-bromophenyl)-morpholine;Morpholine,4-(3-broMophenyl)-;4-(3-Bromophenyl)morpholine96%;1-BROMO-3-(4-MORPHOLINO)BENZENE;4-(3-Bromophenyl)morpholine 96%;1-Bromo-3-(morpholin-4-yl)benzene
CBNumber: CB2664877
Molecular Formula: C10H12BrNO
Formula Weight: 242.11
MOL File: 197846-82-5.mol

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4-(3-BROMOPHENYL)MORPHOLINE Property

Boiling point:: 341.1±37.0 °C(Predicted)
Density: 1.433
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.02±0.40(Predicted)
form: liquid
color: Clear, brown

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
Hazard Note: Irritant
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003639
Product name: 1-bromo-3-(4-morpholino)benzene
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 250 mg
Price: $73.1
Updated: 2025/07/31

TRC

Product number: B700298
Product name: 4-(3-Bromophenyl)morpholine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B700298
Product name: 4-(3-Bromophenyl)morpholine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-V8
Product name: 4-(3-Bromophenyl)morpholine
Purity: 96%
Packaging: 1g
Price: $24
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-V8
Product name: 4-(3-Bromophenyl)morpholine
Purity: 96%
Packaging: 25g
Price: $392
Updated: 2021/12/16

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4-(3-BROMOPHENYL)MORPHOLINE Chemical Properties,Usage,Production

Synthesis

110-91-8

108-36-1

197846-82-5

1,3-Dibromobenzene (50 g, 0.21 mol) and morpholine (15.89 mL, 0.19 mol) were used as raw materials, and both were added to the reaction flask with anhydrous toluene (200 mL) via a syringe under argon protection. After thorough mixing, R-BINAP (1.32 g, 0.0021 mol), palladium(0) dibenzylideneacetone (0.640 g, 0.006 mol) and DBU (25.8 mL, 0.17 mol) were added sequentially. The reaction mixture was stirred at 60 °C, followed by the addition of sodium tert-butoxide (30.55 g, 0.32 mol) and the reaction temperature was raised to 100 °C and continued overnight. Upon completion of the reaction, the suspension was diluted with ethyl acetate, filtered through diatomaceous earth and the organic phase was washed sequentially with water and brine. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent ethyl acetate:hexane (1:1) to afford the target compound 4-(3-bromophenyl)morpholine as a yellow oil (36.5 g, 71% yield). Mass spectrometry (ES+) showed the molecular ion peak m/z 242 ([M+H]+).

References

[1] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 28
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5522 - 5537
[3] Tetrahedron, 2008, vol. 64, # 13, p. 2938 - 2950
[4] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 25-26

4-(3-BROMOPHENYL)MORPHOLINE Preparation Products And Raw materials

Raw materials

Calcium carbonate N,N-Dimethylformamide Sodium sulfate N,N-Diisopropylethylamine Ethyl acetate 2,2'-Dibromodiethyl ether 3-Bromoaniline

Preparation Products

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View Lastest Price from 4-(3-BROMOPHENYL)MORPHOLINE manufacturers

Career Henan Chemical Co

Product: 4-(3-BROMOPHENYL)MORPHOLINE 197846-82-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

197846-82-5, 4-(3-BROMOPHENYL)MORPHOLINERelated Search:

4-(4'-BROMOPHENYL)MORPHOLINE,N-(4-BROMOPHENYL)MORPHOLINE 4-(3-BROMOPHENYL)MORPHOLINE 2-BROMO-4-MORPHOLIN-4-YL-BENZALDEHYDE 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE 1-(3-Bromo-4-morpholin-4-ylphenyl)ethan-1-one, 4-(4-Acetyl-2-bromophenyl)morpholine N-(2-bromophenyl)morpholine-4-sulfonamide N-(3-bromophenyl)morpholine-4-sulfonamide N-(2-amino-4-bromophenyl)morpholine-4-sulfonamide N-(4-bromophenyl)morpholine-4-sulfonamide RARECHEM AN KA 2211 RARECHEM AN KC 2208 SPIRO[2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE-5,5'-(9'-BROMO-1',2',4',4A',5',6'-HEXAHYDRO[1',4']OXAZINO[4',3'-A']QUINOLINE)] RARECHEM AN KA 2212 RARECHEM AN KD 2226 RARECHEM AN KD 2227 RARECHEM AN KC 2207 RARECHEM AN KB 2217 RARECHEM AN KB 2216

1-Bromo-3-(morpholin-4-yl)benzene

4-(3-Bromophenyl)morpholine 96%

1-(3-bromophenyl)-morpholine

N-(3-BroMophenyl)Morpholine

Morpholine,4-(3-broMophenyl)-

4-(3-Bromophenyl)morpholine96%

4-(3-BROMOPHENYL)MORPHOLINE

1-BROMO-3-(4-MORPHOLINO)BENZENE

4-(3-bromophenyl)morpholino

197846-82-5

C10H12BrNO

pharmacetical

Aryl

Organohalides

Halides

Phenyls & Phenyl-Het