ChemicalBook > CAS DataBase List > 3-CHLORO-4-HYDROXYBENZONITRILE

3-CHLORO-4-HYDROXYBENZONITRILE

Product Name: 3-CHLORO-4-HYDROXYBENZONITRILE
CAS No.: 2315-81-3
Chemical Name: 3-CHLORO-4-HYDROXYBENZONITRILE
Synonyms: BUTTPARK 43\57-94;4-Cyano-2-chlorophenol;2-Chloro-4-cyanophenol;3-CHLORO-4-HYDROXYBENZONITRILE;Benzonitrile, 3-chloro-4-hydroxy-;3-Chloro-4-hydroxybenzonitrile >3-CHLORO-4-HYDROXYBENZONITRILE ISO 9001：2015 REACH
CBNumber: CB2669120
Molecular Formula: C7H4ClNO
Formula Weight: 153.57
MOL File: 2315-81-3.mol

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3-CHLORO-4-HYDROXYBENZONITRILE Property

Melting point:: 150 °C
Boiling point:: 266℃
Density: 1.41
Flash point:: 115℃
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 6.37±0.18(Predicted)
color: White to Light yellow
InChI: InChI=1S/C7H4ClNO/c8-6-3-5(4-9)1-2-7(6)10/h1-3,10H
InChIKey: CRYPJUOSZDQWJZ-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(O)C(Cl)=C1
CAS DataBase Reference: 2315-81-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: 3276
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3083
Product name: 3-Chloro-4-hydroxybenzonitrile
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: C3083
Product name: 3-Chloro-4-hydroxybenzonitrile
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $143
Updated: 2025/07/31

TRC

Product number: C384405
Product name: 3-Chloro-4-hydroxybenzonitrile
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 084898
Product name: 3-Chloro-4-hydroxybenzonitrile
Purity: 97%
Packaging: 10g
Price: $177
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC70222
Product name: 3-Chloro-4-hydroxybenzonitrile
Packaging: 100g
Price: $225
Updated: 2021/12/16

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3-CHLORO-4-HYDROXYBENZONITRILE Chemical Properties,Usage,Production

Chemical Properties

off-white crytalline

Synthesis

102151-33-7

2315-81-3

General procedure for the synthesis of 3-chloro-4-hydroxybenzonitrile from 3-chloro-4-methoxybenzonitrile: To a solution of 3-chloro-4-methoxybenzonitrile (4.25 g) in dichloromethane (DCM, 85 mL) was added slowly and dropwise at -78 °C a dichloromethane solution (50.7 mL) of 1 M boron tribromide (BBr3). The reaction mixture was stirred at -78 °C for 10 min and then moved to room temperature to continue stirring overnight. Subsequently, the reaction mixture was heated to 40 °C and stirred for 4.5 days, during which time additional boron tribromide solution (26 mL) was added on the first, second and third days, respectively. Upon completion of the reaction, the reaction mixture was carefully quenched with water and the solid precipitate was collected by filtration. The aqueous and organic layers were separated, the aqueous layer was washed with dichloromethane and the organic phases were combined. The organic layer was dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (Büchi Sepacore system, 50 g silica gel column, solvent A: heptane, solvent B: ethyl acetate (EA), gradient elution (solvent B was increased from 0% to 40%) at a flow rate of 30 mL/min), yielding 3.17 g of brown oily product. Liquid chromatography-mass spectrometry (LC-MS) analysis (Condition A): retention time (tR) = 0.68 min; [M + H]+ peak was not detected.

References

[1] Patent: WO2015/75025, 2015, A1. Location in patent: Page/Page column 93
[2] Patent: WO2015/75023, 2015, A1. Location in patent: Page/Page column 139

3-CHLORO-4-HYDROXYBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-CHLORO-4-HYDROXYBENZONITRILE manufacturers

Career Henan Chemical Co

Product: 3-CHLORO-4-HYDROXYBENZONITRILE 2315-81-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

2315-81-3, 3-CHLORO-4-HYDROXYBENZONITRILERelated Search:

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3-CHLORO-4-HYDROXYBENZONITRILE

BUTTPARK 43\57-94

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3-CHLORO-4-HYDROXYBENZONITRILE ISO 9001：2015 REACH

2315-81-3

Aromatic Nitriles

Phenyls & Phenyl-Het

Chlorine Compounds

Nitriles

Phenols

Phenyls & Phenyl-Het