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CLOPERASTINE

Product Name
CLOPERASTINE
CAS No.
3703-76-2
Chemical Name
CLOPERASTINE
Synonyms
CLOPERASTINE;CLOPERASTINE USP/EP/BP;Cloperastine (base and/or unspecified salts);p-Chlorobenzhydryl2-(1-piperidyl)-ethyl ether;1-[2-[p-Chloro-phenylbenzyl)-oxy]ethy]piperidine;1-[2-(p-Chloro-α-phenylbenzyloxy)ethyl]piperidine;1-[2-[(p-Chloro-α-phenylbenzyl)oxy]ethyl]piperidine;1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)piperidine;1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)-piperidin;1-[2-[[4-Chloro-α-(phenyl)benzyl]oxy]ethyl]piperidine
CBNumber
CB2670438
Molecular Formula
C20H24ClNO
Formula Weight
329.87
MOL File
3703-76-2.mol
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CLOPERASTINE Property

Boiling point:
bp0.06 172-174°; bp0.15 178-180°
Density 
1.0383 (rough estimate)
refractive index 
1.5790 (estimate)
pka
8.69±0.10(Predicted)
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Safety

Toxicity
LD50 unreported in guinea pig: 439mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C587215
Product name
Cloperastine
Packaging
500mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008669
Product name
CLOPERASTINE
Purity
95.00%
Packaging
5MG
Price
$499.19
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008669
Product name
CLOPERASTINE
Purity
95.00%
Packaging
1G
Price
$1575
Updated
2021/12/16
Alichem
Product number
3703762
Product name
1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine
Packaging
1g
Price
$690.8
Updated
2021/12/16
Chemenu
Product number
CM180441
Product name
1-(2-((4-chlorophenyl)(phenyl)methoxy)ethyl)piperidine
Purity
95%
Packaging
1g
Price
$729
Updated
2021/12/16
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CLOPERASTINE Chemical Properties,Usage,Production

Originator

Hustazol,Yoshitomi,Japan,1972

Uses

Cloperastine Hydrochloride (C587213) is an anti-tussive drug as an over-the-counter cold medicine.

Definition

ChEBI: 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine is a diarylmethane.

Manufacturing Process

The manufacture of a related compound is first described. 28.1 parts of pchloro-benzhydryl bromide are heated to boiling, under reflux and with stirring, with 50 parts of ethylene chlorohydrin and 5.3 parts of calcined sodium carbonate. The reaction product is extracted with ether and the ethereal solution washed with water and dilute hydrochloric acid. The residue
from the solution in ether boils at 134° to 137°C under 0.2 mm pressure and is p-chloro-benzhydryl-(β-chloroethyl)ether.
28.1 parts of this ether are heated with 12 parts of methylethylamine (100%) in a sealed tube for 4 hours at 110°C. The product of the reaction is extracted several times with dilute hydrochloric acid, the acid solution made alkaline, in the cold, with concentrated caustic soda solution and the base which separates taken up in ether. The ether extract is washed with concentrated potassium carbonate solution, evaporated down, and the residue distilled in vacuo. The product is β-methylethyl aminoethyl p-chlorobenzhydryl ether, BP 152° to 153°C/0.1 mm.
Reaction with dimethylethylamine instead of methylethylamine leads directly to a quaternary compound, which type of compound can also be obtained by reacting the tertiary aminoethyl ether with reactive esters
If 18 parts of piperidine are used instead of 12 parts of methylethylamine then the same procedure results in the formation of p-chloro-benzyhydril-(β- piperidino-ethyl)ether, boiling at 178° to 180°C under 0.15 mm pressure.

Therapeutic Function

Antitussive

CLOPERASTINE Preparation Products And Raw materials

Raw materials

Preparation Products

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CLOPERASTINE Suppliers

Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2871
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
Henan Anky Chemical Technology Co., Ltd.
Tel
17836913271
Fax
0374-8348899
Email
3224305243@qq.com
Country
China
ProdList
2925
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15494
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4391
Advantage
58
Hebei Mojin Biotechnology Co., Ltd
Tel
+86 13288715578 +8613288715578
Email
sales@hbmojin.com
Country
China
ProdList
12840
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34553
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58
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View Lastest Price from CLOPERASTINE manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
CLOPERASTINE 3703-76-2
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-10-30
Hebei Mojin Biotechnology Co., Ltd
Product
CLOPERASTINE 3703-76-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-01
Jiangsu Boquan Biotechnology Co., Ltd.
Product
Cloperastine 3703-76-2
Price
US $102.00-88.00/g
Min. Order
10g
Purity
99%
Supply Ability
10kg
Release date
2023-02-21

3703-76-2, CLOPERASTINERelated Search:


  • CLOPERASTINE
  • 1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)-piperidin
  • 1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)piperidine
  • 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidin
  • 1-(2-[(4-Chlorophenyl)(phenyl)methoxy]ethyl)piperidine
  • 1-[2-[p-Chloro-phenylbenzyl)-oxy]ethy]piperidine
  • 1-{2-[(p-Chloro-alpha-phenylbenzyl)oxy]ethyl}piperidine
  • Piperidine, 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-
  • Piperidine, 1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-
  • p-Chlorobenzhydryl2-(1-piperidyl)-ethyl ether
  • Cloperastine (base and/or unspecified salts)
  • 1-[2-(p-Chloro-α-phenylbenzyloxy)ethyl]piperidine
  • 1-[2-[(p-Chloro-α-phenylbenzyl)oxy]ethyl]piperidine
  • 1-[2-[[4-Chloro-α-(phenyl)benzyl]oxy]ethyl]piperidine
  • CLOPERASTINE USP/EP/BP
  • 3703-76-2
  • C20H24ClNO