Cefpirome

Product Name: Cefpirome
CAS No.: 84957-29-9
Chemical Name: Cefpirome
Synonyms: CEFPIROME SULPHATE;HR-810;Keitim;CS-283;Cefpiroma;CEFPIROME;Cefpiromum;Cerfpirome;Cefpirome-13C-D3;Cefpiromum [latin]
CBNumber: CB2673505
Molecular Formula: C22H22N6O5S2
Formula Weight: 514.58
MOL File: 84957-29-9.mol

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Cefpirome Property

storage temp.: 2-8°C(protect from light)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-42/43
Safety Statements: 22-26-36/37/39
Toxicity: LD50 in mice, rats (g/kg): 1.9-2.4, 1.9-2.15 i.v.; 3.8-4.2, 5.8-6.55 i.p. (Donaubauer, Mayer)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0001905
Product name: CEFPIROME
Purity: 95.00%
Packaging: 1G
Price: $2804.55
Updated: 2021/12/16

Crysdot

Product number: CD31000621
Product name: Cefpirome
Purity: 95+%
Packaging: 1g
Price: $1424
Updated: 2021/12/16

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Cefpirome Chemical Properties,Usage,Production

Description

This drug is resistant with respect to a broad spectrum of beta-lactamases. Its spectrum of activity is analogous to that of the third-generation cephalosporin cefotaxime (32.1.2.56), although it is more active with respect to some staphylococci, enterococci, and also a few enterobacteria. Synonyms of this drug are cefrom, cedixen, and others.

Uses

Cephalosporin antibiotic Claforan

Definition

ChEBI: Cefpirome is a fourth-generation cephalosporin antibiotic having 6,7-dihydro-5H-cyclopenta[b]pyridinium-1-ylmethyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. It is a cyclopentapyridine and a cephalosporin.

brand name

Cefrom (Hoechst-Roussel).

Antimicrobial activity

A semisynthetic aminothiazoyl cephalosporin formulated as the sulfate for parenteral administration. Activity against common pathogens is similar to that of cefotaxime and ceftriaxone, but it is more active against Ps. aeruginosa. Unlike other cephalosporins it exhibits activity against some strains of enterococci (MIC 4–16 mg/L), but this is of doubtful clinical benefit. It is generally very stable to β-lactamases. It is active against strains of Enterobacter spp., Citrobacter spp., Hafnia spp., Providencia spp., Ser. marcescens and Pr. vulgaris producing molecular class C cephalosporinases. Sten. maltophilia is resistant.
A 1 g intramuscular injection produces a plasma concentration of 25 mg/L after 1.6–2.3 h. A similar intravenous dose achieves a peak concentration of 97 mg/L. The plasma half- life is 1.4–2.3 h and protein binding is around 10%. It is well distributed, achieving therapeutic concentrations in tissues and exudates. It penetrates poorly into CSF in the absence of meningeal inflammation, but concentrations around 2–4 mg/L have been found in patients with purulent meningitis.
Little, if any, of the drug is metabolized and most is excreted unchanged in the urine within 12 h, mainly by glomerular filtration. Clearance declines in proportion to renal function. Around 60% of the drug is removed in 3 h by hemodialysis. Low concentrations are found in breast milk.
Side effects are those common to other cephalosporins. Diarrhea is common and occasional cases of pseudomembranous colitis have been reported.
It is mainly used in the treatment of serious sepsis, particularly nosocomial infections in which resistant Gram-negative pathogens are known or suspected to be involved. It is not widely available, but is marketed in Japan.

Clinical Use

Cefpirome (Cefrom) is a newer parenteral, -lactamase–resistant cephalosporin with a quaternary ammonium groupat the 3-position of the cephem nucleus. Because its potencyagainst Gram-positive and Gram-negative bacteria rivals thatof the first-generation and third-generation cephalosporins,respectively, cefpirome is being touted as the first fourthgenerationcephalosporin. Its broad spectrum includesmethicillin-sensitive staphylococci, penicillin-resistantpneumococci, and β-lactamase–producing strains of E. coli,Enterobacter, Citrobacter, and Serratia spp. Its efficacyagainst P. aeruginosa is comparable with that of ceftazidime.Cefpirome is excreted largely unchanged in the urine with ahalf-life of 2 hours.

Synthesis

Cefpirome, {6R-[6α,7β(Z)]}-1-[(7-{[(2-amino-4-thiazolyl)-(methoximino) acetyl]amino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl- 1-methyl]pyrrolidine chloride (32.1.2.100), is also synthesized by methods described for synthesizing third-generation cephalosporins, in particular, ceftazidime (32.1.2.82).

Cefpirome Preparation Products And Raw materials

Raw materials

Potassium iodide 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide Cefotaxime 6,7-Dihydro-5H-cyclopenta[b]pyridine

Preparation Products

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Cefpirome Suppliers

China 82 Europe 3 Germany 1 India 5 United Kingdom 3 United States 16 Global 110

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

CarboMer, Inc.

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Email: sales@carbomer.com
Country: United States
ProdList: 4026
Advantage: 67

AlliChem, LLC

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Country: United States
ProdList: 6516
Advantage: 60

Riedel-de Haen AG

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ProdList: 6773
Advantage: 87

W & J PharmaChem, Inc.

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Country: United States
ProdList: 595
Advantage: 50

Waterstone Technology, LLC

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Country: United States
ProdList: 6786
Advantage: 30

2A PharmaChem USA

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Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

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Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

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Country: United States
ProdList: 6322
Advantage: 38

ChemPacific Corporation

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Country: United States
ProdList: 6891
Advantage: 51

American Custom Chemicals Corporation

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Country: United States
ProdList: 6820
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View Lastest Price from Cefpirome manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cefpirome 84957-29-9
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-10-19

Longyan Tianhua Biological Technology Co., Ltd

Product: Cefpirome 84957-29-9
Price: US $100.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99
Supply Ability: 999
Release date: 2020-11-06

Shaanxi Dideu Medichem Co. Ltd

Product: Cefpirome 84957-29-9
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 300 MT
Release date: 2020-05-23

84957-29-9, CefpiromeRelated Search:

Cefpiramide acid Iodoform Cefteram pivoxil CEFPIROME SULFATE Cefetamet hydrochloride Ceftizoxime CEFPIROME SULFATE FOR INJECTION Cefpirome Sulphate with Carbonate Cefpirome Acid 2-(2-AMINO-THIAZOL-4-YL)-ACETAMIDE 2-(2-AMINOTHIAZOL-4-YL)ETHYLAMINE Cefpirome

CEFPIROME

CEFPIROME SULPHATE

1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-5H-1-pyrindinium hydroxide, inner salt, 72-(Z)-(O-methyloxime)

3-[(2,3-cyclopenteno-1-pyridinium)methyl]-7-[2-syn-methoxyimino-2-(2-aminothiazol-4-yl)acetamido]ceph-3-em-4-carboxylate

(6R,7R)-7-(()-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-8-oxo-3-(2beta-trimethylenpyridinio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carboxylat

1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-5H-1-pyridinium hydroxide, inner salt

5H-1-Pyrindinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-5,6,7,8-tetrahydro-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-

5H-1-Pyrindinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-

Cefpiroma

Cefpiroma [spanish]

Cefpiromum

Cefpiromum [latin]

HR-810

Keitim

cefpirome sulfate sterile

(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Sinomenine Solution, 100ppm

Cerfpirome

CS-283

(6R,7R)-7-[[(2E)-2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-(6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Cefpirome USP/EP/BP

Cefpirome-13C-D3

84957-29-9

C22H22N6O5S2

Cefpirome

Pharmaceutical intermediate