Denatonium Benzoate
The most bitter compound in the world Chemical structure Uses- Product Name
- Denatonium Benzoate
- CAS No.
- 3734-33-6
- Chemical Name
- Denatonium Benzoate
- Synonyms
- DENATONIUM BENZOATE;BITREX;denatonium;,benzoate;REJEXIT (R);Bitrex? Denatonium Benzoate;Acetylthio-2-Methylpro-Panoyl Chloride;benzyldiethyl (2,6-xylylcarbamoylmethyl)-ammonium;Vilex;ths-839
- CBNumber
- CB2674421
- Molecular Formula
- C28H34N2O3
- Formula Weight
- 446.58
- MOL File
- 3734-33-6.mol
Denatonium Benzoate Property
- Melting point:
- 164-168 °C (lit.)
- Boiling point:
- 555.91°C (rough estimate)
- Density
- 1.1256 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.5800 (estimate)
- Flash point:
- 100℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- methanol: 50 mg/mL, clear, colorless
- form
- Solid
- color
- White to Off-White
- Odor
- at 100.00?%. bland
- Water Solubility
- 42.555g/L at 25℃
- Merck
- 14,2891
- BRN
- 8179408
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- VWTINHYPRWEBQY-UHFFFAOYSA-N
- LogP
- 2.2 at 25℃
- CAS DataBase Reference
- 3734-33-6(CAS DataBase Reference)
- EPA Substance Registry System
- Denatonium benzoate (3734-33-6)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38-20/21/22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 2
- RTECS
- BO6650000
- TSCA
- Yes
- HS Code
- 29242995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1171003
- Product name
- Denatonium benzoate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 52487
- Product name
- Denatonium benzoate
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $74.7
- Updated
- 2022/05/15
- Product number
- D2124
- Product name
- Denatonium Benzoate
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $71
- Updated
- 2024/03/01
- Product number
- D2124
- Product name
- Denatonium Benzoate
- Purity
- >98.0%(HPLC)
- Packaging
- 25g
- Price
- $183
- Updated
- 2024/03/01
- Product number
- J61048
- Product name
- Denatonium benzoate
- Packaging
- 1g
- Price
- $34.3
- Updated
- 2024/03/01
Denatonium Benzoate Chemical Properties,Usage,Production
The most bitter compound in the world
Denatonium benzoate is now known as the world's most bitter compound. If we set the bitter degree of quinine as datum 1, the degree of bitterness of the product would be 1000. A concentration of 10ppm solution is already too bitter to bear for most people. The vast majority of its applications are related to its bitter flavor. It is an inexpensive and efficient alternative to its counterparts such as strychnine, bitter lignin, quinine, wood song glycosides, saponins grapefruit.
Denatonium benzoate is commonly used as aversive agent to prevent people from eating other toxic but tasteless substance. For example, it has been added into industrial alcohol, ethylene glycol or methanol which has similar taste as ordinary wine, antifreeze, paint, toilet cleaners, animals disperse, liquid soaps and shampoos. Moreover, it has been also added into special nail polish agents, to avoid child’s bad habit of biting fingers, as well as being the repellent for expulsing large beasts. However, the effect of Long-term exposure to this substance on human health is still unclear.
Chemical structure
Denatonium benzoate is a kind of quaternary ammonium salt formed by the combination of the quaternary ammonium cation and inert anion such as benzoic acid or saccharin anion. The structure of its cation form is similar to that of a local anesthetic lidocaine with the only difference being an additional benzyl functional group located on the nitrogen atom of the amino.
Uses
Flavoring agent.
Chemical Properties
white crystals
Chemical Properties
Denatonium benzoate occurs as an odorless, very bitter tasting, white crystalline powder or granules.
Uses
The bitterest compound knownDenatonium benzoate is used as an alcohol denaturant and flavor in pharmaceuticals. It is also used in antifreeze, nail biting preventions, respirator mask fit-testing, animal repellents, liquid soaps and shampoos. Further, it is used in air care products. It acts as H1 antihistamine. In addition to this, it is used as a disinfectant.
Uses
Pharmaceutic aid (alcohol denaturant; flavor). Added to toxic substances as a deterrent to accidental ingestion. Can replace brucine or quassin as denaturant for ethyl alcohol.
Production Methods
Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate.
brand name
Bitrex (Mac Farlan Smith, Scotland).
Flammability and Explosibility
Not classified
Pharmaceutical Applications
Denatonium benzoate is among the most bitter of substances
known and is detectable at concentrations of approximately 10 ppb.
In pharmaceutical and other industrial applications it is added to
some products as a deterrent to accidental ingestion. It is most
commonly used at levels of 5–500 ppm. Denatonium benzoate may
also be used to replace brucine or quassin as a denaturant for
ethanol.
In pharmaceutical formulations, denatonium benzoate has been
used as a flavoring agent in placebo tablets, and in a topical
formulation it has been used in an anti-nailbiting preparation.
Safety
Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,therehasbeenasinglereportof contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate.
LD50 (rabbit, oral): 0.508g/kg
LD50 (rat, oral): 0.584g/kg
Synthesis
A method for synthesizing Denatonium Benzoate comprises the following steps: (1) adding benzyl halide to a reactor containing raw material lidocaine under stirring and at a certain temperature, wherein the reaction temperature is from room temperature to 130°C, and the ratio of lidocaine to benzyl halide is 1:1 to 1:2; (2) after the reaction is complete, adding solvent and metal hydroxide; (3) adding benzoic acid, after the reaction is completed, the generated benzyl ammonium benzoate is filtered, washed, concentrated, and washed to obtain the product benzyl ammonium benzoate.
storage
Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light.
Incompatibilities
Denatonium benzoateis incompatible with strongoxidizing agents.
Regulatory Status
Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution).
Denatonium Benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Denatonium Benzoate manufacturers
- Product
- DENATONIUM BENZOATE,99% 3734-33-6
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300 Tons/ year
- Release date
- 2019-12-25
- Product
- Denatonium Benzoate Anhydrous 3734-33-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20Ton
- Release date
- 2024-11-13
- Product
- Denatonium Benzoate Anhydrous 3734-33-6
- Price
- US $120.00-65.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-28