ChemicalBook > CAS DataBase List > (+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

Product Name
(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM
CAS No.
127299-93-8
Chemical Name
(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM
Synonyms
BRL 37344A;BRL 37344 SODIUM;BRL 37344 Na Salt;BRL 37344 SODIUM SALT;BRL 37344 hydrate sodium salt;(R,R)-(+/-)-4-(2-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxyaceticacid;(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM;(R*,R*)-(+/-)-4-[2-[(2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO]PROPYL]PHENOXYACETIC ACID, SODIUM SALT;(±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate;Acetic acid, 2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-, sodium salt (1:1), rel-
CBNumber
CB2675428
Molecular Formula
C19H23ClNNaO4
Formula Weight
387.84
MOL File
127299-93-8.mol
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(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Property

storage temp. 
Store at RT
solubility 
H2O: 10 mg/mL
form 
powder
color 
white
Water Solubility 
Soluble to 100 mM in water
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B169
Product name
BRL 37344 sodium salt hydrate
Purity
solid
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
B169
Product name
BRL 37344 sodium salt hydrate
Purity
solid
Packaging
25mg
Price
$293.4
Updated
2024/03/01
Cayman Chemical
Product number
18622
Product name
BRL 37344 (sodium salt)
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
18622
Product name
BRL 37344 (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
18622
Product name
BRL 37344 (sodium salt)
Purity
≥98%
Packaging
10mg
Price
$216
Updated
2024/03/01
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(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Chemical Properties,Usage,Production

Uses

BRL 37344 Sodium is a potent and selective b3-AR agonist.

Biological Activity

Potent and selective β 3 adrenoceptor agonist (K i values are 287, 1750 and 1120 nM for β 3 , β 1 and β 2 receptors respectively). Also available as part of the β -Adrenoceptor Agonist Tocriset™ .

Biochem/physiol Actions

BRL 37344 is a selective β3-adrenoceptor agonist. Studies support the hypothesis that there are peripheral β3 adrenergic receptors that can reduce food intake and that central β2 or β3 adrenergic receptors mediate the peripheral effects of the β3 agonist.

storage

Store at RT

References

[1]. simard pm, atgié c, mauriège p, et al. comparison of the lipolytic effects of norepinephrine and brl 37344 in rat brown and white adipocytes. obes res, 1994, 2(5): 424-431.
[2]. kozlovski vi, chlopicki s, gryglewski rj. effects of two beta3-agonists, cgp 12177a and brl 37344, on coronary flow and contractility in isolated guinea pig heart. j cardiovasc pharmacol, 2003, 41(5): 706-713.
[3]. reverte m, rivas-cabañero l. effects of the beta 3-adrenoceptor agonist brl 37344 on lipomobilization and plasma glucose levels in conscious fasted rabbits. can j physiol pharmacol, 1996, 74(3): 251-256.
[4]. kasahara h, muto s, motokawa y, et al. β3-adrenoceptor-mediated increased circulating transaminase levels in mice treated with its agonist brl 37344. j toxicol sci, 2010, 35(5): 779-784.

(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Suppliers

China 13 Germany 2 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 8 Global 29
Carbosynth
Tel
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sales@carbosynth.com
Country
United Kingdom
ProdList
6005
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Tocris Bioscience
Tel
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Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
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MOLEKULA Ltd.
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Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
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66

127299-93-8, (+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUMRelated Search:

Phenoxyacetic acid Phenoxyacetic acid sodium salt 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM (+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

  • (+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM
  • (R*,R*)-(+/-)-4-[2-[(2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO]PROPYL]PHENOXYACETIC ACID, SODIUM SALT
  • (±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate
  • BRL 37344 Na Salt
  • BRL 37344A
  • BRL 37344 SODIUM
  • BRL 37344 SODIUM SALT
  • (R,R)-(+/-)-4-(2-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxyaceticacid
  • BRL 37344 hydrate sodium salt
  • BRL 37344A, (±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate
  • Acetic acid, 2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-, sodium salt (1:1), rel-
  • 127299-93-8
  • C19H21NO4ClNa
  • C19H21ClNNaO4
  • C19H21ClNNaO4xH2O
  • Adrenoceptor