(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM
- Product Name
- (+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM
- CAS No.
- 127299-93-8
- Chemical Name
- (+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM
- Synonyms
- BRL 37344A;BRL 37344 SODIUM;BRL 37344 Na Salt;BRL 37344 SODIUM SALT;BRL 37344 hydrate sodium salt;(R,R)-(+/-)-4-(2-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxyaceticacid;(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM;(R*,R*)-(+/-)-4-[2-[(2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO]PROPYL]PHENOXYACETIC ACID, SODIUM SALT;(±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate;Acetic acid, 2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-, sodium salt (1:1), rel-
- CBNumber
- CB2675428
- Molecular Formula
- C19H23ClNNaO4
- Formula Weight
- 387.84
- MOL File
- 127299-93-8.mol
(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Property
- storage temp.
- Store at RT
- solubility
- H2O: 10 mg/mL
- form
- powder
- color
- white
- Water Solubility
- Soluble to 100 mM in water
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- B169
- Product name
- BRL 37344 sodium salt hydrate
- Purity
- solid
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- B169
- Product name
- BRL 37344 sodium salt hydrate
- Purity
- solid
- Packaging
- 25mg
- Price
- $293.4
- Updated
- 2024/03/01
- Product number
- 18622
- Product name
- BRL 37344 (sodium salt)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 18622
- Product name
- BRL 37344 (sodium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 18622
- Product name
- BRL 37344 (sodium salt)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $216
- Updated
- 2024/03/01
(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Chemical Properties,Usage,Production
Uses
BRL 37344 Sodium is a potent and selective b3-AR agonist.
Biological Activity
Potent and selective β 3 adrenoceptor agonist (K i values are 287, 1750 and 1120 nM for β 3 , β 1 and β 2 receptors respectively). Also available as part of the β -Adrenoceptor Agonist Tocriset™ .
Biochem/physiol Actions
BRL 37344 is a selective β3-adrenoceptor agonist. Studies support the hypothesis that there are peripheral β3 adrenergic receptors that can reduce food intake and that central β2 or β3 adrenergic receptors mediate the peripheral effects of the β3 agonist.
storage
Store at RT
References
[1]. simard pm, atgié c, mauriège p, et al. comparison of the lipolytic effects of norepinephrine and brl 37344 in rat brown and white adipocytes. obes res, 1994, 2(5): 424-431.
[2]. kozlovski vi, chlopicki s, gryglewski rj. effects of two beta3-agonists, cgp 12177a and brl 37344, on coronary flow and contractility in isolated guinea pig heart. j cardiovasc pharmacol, 2003, 41(5): 706-713.
[3]. reverte m, rivas-cabañero l. effects of the beta 3-adrenoceptor agonist brl 37344 on lipomobilization and plasma glucose levels in conscious fasted rabbits. can j physiol pharmacol, 1996, 74(3): 251-256.
[4]. kasahara h, muto s, motokawa y, et al. β3-adrenoceptor-mediated increased circulating transaminase levels in mice treated with its agonist brl 37344. j toxicol sci, 2010, 35(5): 779-784.
(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
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