ChemicalBook > CAS DataBase List > Satraplatin

Satraplatin

Product Name
Satraplatin
CAS No.
129580-63-8
Chemical Name
Satraplatin
Synonyms
JM 216;C081294;BMY 45594;BMS 182751;SATRAPLATIN;Satraplatin(JM216);BMS-182751;BMY-45594;JM-216;bis(acetato-o)amminedichloro(cyclohexanamine)-pt;Bis-acetatoamminedichlorocyclohexylamine platinum(iv);(OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum
CBNumber
CB2675796
Molecular Formula
C10H20Cl2N2O4Pt
Formula Weight
498.26
MOL File
129580-63-8.mol
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Satraplatin Property

storage temp. 
Store at -20°C
solubility 
DMF: 0.16 mg/mL; DMSO: 0.5 mg/mL
form 
Powder
color 
Off-white to yellow
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Safety

Toxicity
LD50 in mice (mg/kg): 30 i.p.; 330 orally (Kelland)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
20537
Product name
Satraplatin
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
20537
Product name
Satraplatin
Purity
≥98%
Packaging
5mg
Price
$262
Updated
2024/03/01
Cayman Chemical
Product number
20537
Product name
Satraplatin
Purity
≥98%
Packaging
10mg
Price
$437
Updated
2024/03/01
Biosynth Carbosynth
Product number
FS65158
Product name
Satraplatin
Packaging
10mg
Price
$95
Updated
2021/12/16
Biosynth Carbosynth
Product number
FS65158
Product name
Satraplatin
Packaging
50mg
Price
$333
Updated
2021/12/16
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Satraplatin Chemical Properties,Usage,Production

Uses

Antineoplastic.

Definition

ChEBI: A platinum coordination entity that consists of a central platunum atom bound to chloro (x2), acetate (x2), amino, and cyclohexylamino groups. Used for treatment of advanced prostate cancer.

Pharmaceutical Applications

Satraplatin (JM216, cis,trans,cis-[PtCl2(OAc)2(NH3)(C6H5NH2)]) is a Pt(IV) or Pt4+ complex, which is active by oral administration, as it is more hydrophobic than cisplatin. This form of administration is very attractive because of the convenience and freedom it provides to the patient. Satraplatin also has a milder toxicity profile and is shows no cross-resistance with cisplatin. Satraplatin in combination with prednisone has completed phase III clinical trials against hormone-refractory prostate cancer. The results were very encouraging, but the overall survival rate did not improve significantly enough. As a result, the fast-track approval of the FDA was not granted.
Structurally, satraplatin consists of a Pt(IV) centre, which is coordinated by six ligands forming a close to octahedral geometry. In general, octahedral Pt(IV) complexes (low-spin d6) are much more kinetically inert than square planar Pt(II) complexes.

Clinical Use

This newest organometallic agent currently is in clinical trials as a second-line agent for the treatment of hormone-refractory prostate cancer . There is hope that it also will find value in ovarian cancer and small cell lung cancer.

Side effects

As with other organoplatinum complexes, the diaquo form is active. At this early stage, the toxicity profile appears to be mild, with dose-related myelosuppression, particularly neutropenia and thrombocytopenia, being the major use-limiting side effect.

Metabolism

Unlike the square-planar Pt(II) complexes currently on the market, it is active by the oral route. It is metabolized quickly in whole blood, producing up to six metabolites. The major metabolite is the desacetoxy analogue.

Satraplatin Preparation Products And Raw materials

Raw materials

Preparation Products

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Satraplatin Suppliers

China 81 Europe 2 Germany 1 India 1 South Korea 1 United Kingdom 5 United States 19 Global 110
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View Lastest Price from Satraplatin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Satraplatin 129580-63-8
Price
US $0.00/g
Min. Order
10g
Purity
98%-102%
Supply Ability
100g
Release date
2022-12-29
Career Henan Chemical Co
Product
Satraplatin 129580-63-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200KG
Release date
2019-07-01

129580-63-8, SatraplatinRelated Search:

Glycyl-glycyl-glycine ETHYL DICHLOROACETATE Dicyclohexylamine Cyclohexylamine trans,trans-2,4-Undecadienal Sodium dichloroacetate Dichloroacetic acid LOBAPLATIN DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Picoplatin Eptaplatin (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate DIBROMO(1,5-CYCLOOCTADIENE)PLATINUM(II) Satraplatin TRANSFAT JM 221 (ammine)cyclohexylaminedichloroplatinum(II)

  • bis(acetato-o)amminedichloro(cyclohexanamine)-pt
  • platinum (lv) cis-dichloro-trans-bis(acetato-o)ammine(cyclohexanamine)
  • SATRAPLATIN
  • JM 216
  • Bis-acetatoamminedichlorocyclohexylamine platinum(iv)
  • C081294
  • Platinum, bis(acetato-o)amminedichloro(cyclohexanamine)-, (oc-6-43)-
  • Satraplatin(JM216)
  • (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum
  • BMS 182751
  • BMY 45594
  • Cis-dichloro-trans-diacetoxyl-cis-amino, cyclohexaneplatinum (IV)
  • BMS-182751;BMY-45594;JM-216
  • (OC-6-43)-Bis(acetato-0)ammine-dichloro(cyclohexanamine)platinum(IV)
  • 129580-63-8
  • C10H22Cl2N2O4Pt
  • C6H13NC4H6Cl2O4PtH3N
  • Anticancer