LOBAPLATIN

Product Name: LOBAPLATIN
CAS No.: 135558-11-1
Chemical Name: LOBAPLATIN
Synonyms: d19466;Lobaplatin (D-19466);Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-;Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-[D-19466;Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,κN′][(2S)-2-(hydroxy-κO)propanoato(2-)-κO]-, (SP-4-3)-;Platinum,[rel-(1R,2R)-1,2-cyclobutanedimethanamine-kN,kN'][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)- (9CI);Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-.kappa.N,.kappa.N'][(2S)-2-(hydroxy-.kappa.O)propanoato(2-)-.kappa.O]-, (SP-4-3)- (9CI) (CA INDEX NAME);cell cycle,Apoptosis,Caspase,Lobaplatin,Bax,esophageal squamous cell carcinoma,Inhibitor,D19466,D 19466,inhibit,Bcl-2 Family,diastereometric mixture of platinum(II) complexe
CBNumber: CB4741909
Molecular Formula: C9H18N2O3Pt
Formula Weight: 397.33
MOL File: 135558-11-1.mol

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LOBAPLATIN Property

Melting point:: 220° (dec)
storage temp.: Store at -20°C
solubility: Water: ≥ 50 mg/mL (125.84 mM; DMSO can inactivate Lobaplatin's activity)
form: Solid
color: White to off-white
Water Solubility: Water: ≥ 50 mg/mL (125.84 mM; DMSO can inactivate Lobaplatin's activity)

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Safety

Toxicity: LD50 i.p. in mice: 46 mg/kg (Voegeli)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3213
Product name: Lobaplatin
Purity: ≥98% (NMR)
Packaging: 5MG
Price: $91.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3213
Product name: Lobaplatin
Purity: ≥98% (NMR)
Packaging: 25MG
Price: $370
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: API0003196
Product name: LOBAPLATIN
Purity: 95.00%
Packaging: 5MG
Price: $497.18
Updated: 2021/12/16

CSNpharm

Product number: CSN20587
Product name: Lobaplatin
Packaging: 10mg
Price: $725
Updated: 2021/12/16

CSNpharm

Product number: CSN20587
Product name: Lobaplatin
Packaging: 50mg
Price: $2093
Updated: 2021/12/16

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LOBAPLATIN Chemical Properties,Usage,Production

Uses

Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer[1][2][3].

Biological Activity

Lobaplatin (D-19466) is a third-generation platinum anticancer agent in vitro and in vivo, consisting of ~50:50 mixture of the two trans-1,2-cyclobutanedimethanamine diastereomers in complex with L-lactic acid. Llobaplatin shows antitumor efficacy against various human cancer cancer xenografts and significantly prolongs the survival of mice bearing P388 leukemia (mean life span increase post single i.p. in mg/kg = 46%/4.64 & 77/14.7). Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.

in vivo

Lobaplatin (5 and 10 mg/kg; i.p.; once a week, for 3 weeks) suppresses tumor growth of esophageal squamous cell carcinoma (ESCC) xenograft^[1].

Animal Model:	Male BALB/c nude mice (4-6 weeks) with ESCC xenograft^[1]
Dosage:	Intraperitoneal injection; once a week, for 3 weeks
Administration:	5 and 10 mg/kg
Result:	Suppressed tumor volumes in a dose-dependent manner. Increased expressions of Bax and decreased expressions of Bcl-2.

References

[1] Du L, et, al. Antitumor activity of Lobaplatin against esophageal squamous cell carcinoma through caspase-dependent apoptosis and increasing the Bax/Bcl-2 ratio. Biomed Pharmacother. 2017 Nov;95:447-452. DOI:10.1016/j.biopha.2017.08.119
[2] Wu Q, et, al. Lobaplatin arrests cell cycle progression in human hepatocellular carcinoma cells. J Hematol Oncol. 2010 Oct 31;3:43. DOI:10.1186/1756-8722-3-43
[3] McKeage MJ. Lobaplatin: a new antitumour platinum drug. Expert Opin Investig Drugs. 2001 Jan;10(1):119-28. DOI:10.1517/13543784.10.1.119

LOBAPLATIN Preparation Products And Raw materials

Raw materials

Preparation Products

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LOBAPLATIN Suppliers

China 59 Europe 2 Germany 1 India 1 Japan 1 United Kingdom 4 United States 9 Global 77

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7938
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509; 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 4968
Advantage: 58

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Candia Thamtech Company Limited

Tel: 0371-86615086 18203638366 0371-86159066 13526786601
Fax: 0371-86159066
Country: China
ProdList: 2015
Advantage: 60

Guangzhou Ciming Biological Technology Co., Ltd.

Tel: 020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax: +86 (20)38082986
Country: China
ProdList: 830
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Zhengzhou Huiju Chemical Co., Ltd.

Tel: 0371-55900031 18137872243
Fax: QQ：2853979815
Email: 2853979815@qq.com
Country: China
ProdList: 9975
Advantage: 55

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

135558-11-1, LOBAPLATINRelated Search:

Cisplatin Carboplatin cis-Diamminediiodoplatinum Nedaplatin DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Picoplatin Eptaplatin Satraplatin (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate DIBROMO(1,5-CYCLOOCTADIENE)PLATINUM(II)

d19466

Lobaplatin (D-19466)

Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-.kappa.N,.kappa.N'][(2S)-2-(hydroxy-.kappa.O)propanoato(2-)-.kappa.O]-, (SP-4-3)- (9CI) (CA INDEX NAME)

Platinum,[rel-(1R,2R)-1,2-cyclobutanedimethanamine-kN,kN'][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)- (9CI)

Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-

Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-[D-19466

cell cycle,Apoptosis,Caspase,Lobaplatin,Bax,esophageal squamous cell carcinoma,Inhibitor,D19466,D 19466,inhibit,Bcl-2 Family,diastereometric mixture of platinum(II) complexe

Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,κN′][(2S)-2-(hydroxy-κO)propanoato(2-)-κO]-, (SP-4-3)-

135558-11-1

C6H14N2C3H4O3Pt

C9H18N2O3Pt