LOBAPLATIN

ChemicalBook > CAS DataBase List > LOBAPLATIN

Product Name: LOBAPLATIN
CAS No.: 135558-11-1
Chemical Name: LOBAPLATIN
Synonyms: d19466;Lobaplatin (D-19466);Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-;Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-[D-19466;Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,κN′][(2S)-2-(hydroxy-κO)propanoato(2-)-κO]-, (SP-4-3)-;Platinum,[rel-(1R,2R)-1,2-cyclobutanedimethanamine-kN,kN'][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)- (9CI);Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-.kappa.N,.kappa.N'][(2S)-2-(hydroxy-.kappa.O)propanoato(2-)-.kappa.O]-, (SP-4-3)- (9CI) (CA INDEX NAME);cell cycle,Apoptosis,Caspase,Lobaplatin,Bax,esophageal squamous cell carcinoma,Inhibitor,D19466,D 19466,inhibit,Bcl-2 Family,diastereometric mixture of platinum(II) complexe
CBNumber: CB4741909
Molecular Formula: C9H18N2O3Pt
Formula Weight: 397.33
MOL File: 135558-11-1.mol

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LOBAPLATIN Property

Melting point:: 220° (dec)
storage temp.: Store at -20°C
solubility: Water: ≥ 50 mg/mL (125.84 mM; DMSO can inactivate Lobaplatin's activity)
form: Solid
color: White to off-white
Water Solubility: Water: ≥ 50 mg/mL (125.84 mM; DMSO can inactivate Lobaplatin's activity)

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Safety

Toxicity: LD50 i.p. in mice: 46 mg/kg (Voegeli)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3213
Product name: Lobaplatin
Purity: ≥98% (NMR)
Packaging: 5MG
Price: $89.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3213
Product name: Lobaplatin
Purity: ≥98% (NMR)
Packaging: 25MG
Price: $360
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0003196
Product name: LOBAPLATIN
Purity: 95.00%
Packaging: 5MG
Price: $497.18
Updated: 2021/12/16

CSNpharm

Product number: CSN20587
Product name: Lobaplatin
Packaging: 10mg
Price: $725
Updated: 2021/12/16

CSNpharm

Product number: CSN20587
Product name: Lobaplatin
Packaging: 50mg
Price: $2093
Updated: 2021/12/16

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LOBAPLATIN Chemical Properties,Usage,Production

Biological Activity

Lobaplatin (D-19466) is a third-generation platinum anticancer agent in vitro and in vivo, consisting of ~50:50 mixture of the two trans-1,2-cyclobutanedimethanamine diastereomers in complex with L-lactic acid. Llobaplatin shows antitumor efficacy against various human cancer cancer xenografts and significantly prolongs the survival of mice bearing P388 leukemia (mean life span increase post single i.p. in mg/kg = 46%/4.64 & 77/14.7). Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.

LOBAPLATIN Preparation Products And Raw materials

Raw materials

Preparation Products

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135558-11-1, LOBAPLATINRelated Search:

Cisplatin Carboplatin cis-Diamminediiodoplatinum Nedaplatin DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Picoplatin Eptaplatin Satraplatin (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate DIBROMO(1,5-CYCLOOCTADIENE)PLATINUM(II)

d19466

Lobaplatin (D-19466)

Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-.kappa.N,.kappa.N'][(2S)-2-(hydroxy-.kappa.O)propanoato(2-)-.kappa.O]-, (SP-4-3)- (9CI) (CA INDEX NAME)

Platinum,[rel-(1R,2R)-1,2-cyclobutanedimethanamine-kN,kN'][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)- (9CI)

Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-

Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-[D-19466

cell cycle,Apoptosis,Caspase,Lobaplatin,Bax,esophageal squamous cell carcinoma,Inhibitor,D19466,D 19466,inhibit,Bcl-2 Family,diastereometric mixture of platinum(II) complexe

Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,κN′][(2S)-2-(hydroxy-κO)propanoato(2-)-κO]-, (SP-4-3)-

135558-11-1

C6H14N2C3H4O3Pt

C9H18N2O3Pt